Results 131 to 140 of about 681,334 (361)

Simultaneous quantification of 12 different nucleotides and nucleosides released from renal epithelium and in human urine samples using ion-pair reversed-phase HPLC [PDF]

, 2012
Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.
Alberto Contreras-Sanz, BD Gill, C Crawford, Claire M. Peppiatt-Wildman, DR Ferguson, DR Schneider, EM Schwiebert, EW Inscho, EW Inscho, FQ Yang, G Burnstock, G Burnstock, G Burnstock, G Manfredi, G Xu, HA Neufeld, HA Praetorius, HA Praetorius, Hardyal S. Gill, HM Liebich, I Kugelgen von, I Kugelgen von, J Czarnecka, James Malone-Lee, JC Mathies, Jennifer C. Jacoby, JM Buescher, JO Svensson, JR Gever, K Sugaya, Kevin M. G. Taylor, KH Schram, KR Kim, LA Birder, LC Rump, LD Todorov, M Cichna, M Katayama, MA Bailey, N Ozer, N Yamaoka, NS Zur, P Bodin, P Vinas, PD Wilson, R Corriden, RC Calvert, Rebecca E. Birch, RL Cordell, S Tatur, S Wiener, SA Levesque, Scott S. P. Wildman, Toby S. Scott-Ward, V Jankowski, V Kumar, W Yu, Y Cheng, Y Sun, Y Sun, Y Zheng   +60 more
core   +2 more sources

Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances

Frontiers in Immunology, 2018
If misregulated, macrophage (Mϕ)–T cell interactions can drive chronic inflammation thereby causing diseases, such as rheumatoid arthritis (RA). We report that in a proinflammatory environment, granulocyte-Mϕ (GM-CSF)- and Mϕ colony-stimulating factor (M-
Anna Ohradanova-Repic, Christian Machacek, Celine Charvet, Celine Charvet, Celine Charvet, Franck Lager, Franck Lager, Franck Lager, Delphine Le Roux, Delphine Le Roux, Delphine Le Roux, René Platzer, Vladimir Leksa, Vladimir Leksa, Goran Mitulovic, Thomas R. Burkard, Gerhard J. Zlabinger, Michael B. Fischer, Michael B. Fischer, Vincent Feuillet, Vincent Feuillet, Vincent Feuillet, Gilles Renault, Gilles Renault, Gilles Renault, Stephan Blüml, Miroslav Benko, Miloslav Suchanek, Johannes B. Huppa, Takami Matsuyama, Artur Cavaco-Paulo, Georges Bismuth, Georges Bismuth, Georges Bismuth, Hannes Stockinger   +34 more
doaj   +1 more source

Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, EarlyView.
This article summarizes significant technological advancements in materials, photonic devices, and bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, and on‐skin health monitoring.
Seunghyeb Ban, Hoon Yi, Jaejin Park, Yunuo Huang, Ki Jun Yu, Woon‐Hong Yeo   +5 more
wiley   +1 more source

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]

, 2017
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M., Alzahrani, Khalid J.H., Barrett, Michael P., Creek, Darren J., De Koning, Harry P., Eze, Anthonius A., Looi, Wan Limm, Tagoe, Daniel N.A.   +7 more
core   +2 more sources

Tumor-infiltrating CD39+ γδTregs are novel immunosuppressive T cells in human colorectal cancer

OncoImmunology, 2017
Tumor microenvironment (TME) promotes immune suppression through recruiting and expanding suppressive immune cells such as regulatory T cells (Tregs) to facilitate cancer progression.
Guoming Hu, Pin Wu, Pu Cheng, Zhigang Zhang, Zhen Wang, Xiuyan Yu, Xuan Shao, Dang Wu, Jun Ye, Tao Zhang, Xiaochen Wang, Fuming Qiu, Jun Yan, Jian Huang   +13 more
doaj   +1 more source

Maternal Death Following Medical Treatment of Paroxysmal Supraventricular Tachycardia in Late Gestation

Taiwanese Journal of Obstetrics & Gynecology, 2005
Objective: We present an unusual case of maternal death following medical treatment of paroxysmal supraventricular tachycardia (PSVT) in late gestation. Case Report: A 30-year-old woman, gravida 1, para 0, came to the outpatient clinic of our obstetrics ...
Ping-Hung Kuo, Kung-Liahng Wang, Jen-Ruei Chen, Chih-Ping Chen, Jen-Jui Lin, Ming-Chao Huang, Hung-I Yeh   +6 more
doaj   +1 more source

The roles of adenosine and adenosine receptors in bone remodeling

Frontiers in Bioscience, 2011
Adenosine regulates a wide variety of physiological processes including heart rate, vasodilation and inflammation through the activation of specific cell surface adenosine receptors. In addition to these well-established roles of adenosine, recent genetic and pharmacological research has implicated adenosine as an important regulator in bone remodeling.
Bruce N. Cronstein, Wenjie He
openaire   +3 more sources

Energy from food [PDF]

arXiv, 2017
Expressing the energy content of food as the heat energy released by its combustion is potentially misleading. Food is used to produce adenosine triphosphate (ATP). The free energy of conversion of ATP into adenosine diphosphate is used directly for processes such as muscular contraction, without the need for intermediate heat production. The number of
arxiv  

Photonic Nanomaterials for Wearable Health Solutions

Advanced Materials, EarlyView.
This review discusses the fundamentals and applications of photonic nanomaterials in wearable health technologies. It covers light‐matter interactions, synthesis, and functionalization strategies, device assembly, and sensing capabilities. Applications include skin patches and contact lenses for diagnostics and therapy. Future perspectives emphasize AI‐
Taewoong Park, Jung Woo Leem, Young L. Kim, Chi Hwan Lee   +3 more
wiley   +1 more source

Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]

, 2013
During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a ...
Dunwiddie TV, Magnus J. E. Richardson, Mark J. Wall, Michael I. Kerr   +3 more
core   +1 more source