Results 141 to 150 of about 475,417 (315)

Consequences of eliminating adenosine A(1) receptors in mice

, 2003
The second coding exon of the adenosine A, receptor gene was eliminated by homologous recombination. The phenotype of mice (mixed C57B6/129OlaHsd background) was studied, using siblings from matings of heterozygous mice.
Alberto Fernández‐Teruel, Masino, SA, Hardemark, A, Ollerstam, A, Susan A. Masino, Hilchen Sommerschild, Guro Valen, Zsuzsanna Wiesenfeld‐Hallin, Poelchen, W, Johansson, B, Bertil B. Fredholm, Johansson, C, Halldner, L, Persson, AEG, Xiao‐Jun Xu, Dunwiddie, TV, Xu, XJ, Nancy R. Zahniser, Lydia Giménez‐Llort, Catarina Johansson, Brown, R, Anna Ollerstam, Cecilia Lövdahl, Ole Skøtt, Milos Pekny, Lund University., Lihong Diao, A. Erik G. Persson, Anna Hårdemark, Schulte, G, Samuel Gebré‐Medhin, Valen, G, Peter Thorén, Shinichi Tokuno, Eric Herlenius, Zahniser, NR, Fredholm, BB, Russell Brown, Wiesenfeld-Hallin, Z, Gebre-Medhin, Samuel, Sommerschild, H, Linda Halldner, Tokuno, S, Peter Illes, Gimenez-Llort, L, Illes, P, Björn Johansson, Gunnar Schulte, Thomas V. Dunwiddie, Thoren, P, Herlenius, E, Pekny, S, Wolfgang Poelchen, Diao, LH, Escorihuela, RM, Skott, O, Gebre-Medhin, Samuel,, Rosa M. Escorihuela, Fernandez-Teruel, A, Lovdahl, C   +59 more
core   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Synthetic Small-Molecule Ligands Targeted to Adenosine Receptors: Is There Potential Towards Ischemic Heart Disease?

Cells
Ischemic heart disease (IHD) represents a leading cause of global morbidity and mortality. Despite significant advances in treatment achieved over recent decades, as well as various therapeutic strategies available to manage IHD progression currently ...
Qi Xu, Yaw Nana Opoku, Kalwant S. Authi, Agostino Cilibrizzi   +3 more
doaj   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Adenosine-Related Compounds as an Enhancer for Peroxidase-Mimicking Activity of Nanomaterials: Application to Sensing of Heparin Level in Human Plasma and Total Sulfate Glycosaminoglycan Content in Synthetic Cerebrospinal Fluid

, 2018
A variety of compounds, such as DNA and protein, have been demonstrated to be effective in suppressing the catalytic activity of peroxidase-like nanomaterials.
Jyun-Guo You (5883437), Yen-Ting Wang (3820363), Jyun-Guo You, Yen-Ting Wang, Wei-Lung Tseng, Wei-Lung Tseng (1499176)   +5 more
core   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Effects of Fertilization Promoting Peptide, Adenosine, and Pentoxifylline on Thawed Human Sperm

, 2009
Fertilization promoting peptide (FPP) and adenosine were demonstrated to be potential modulators of sperm capacitation in mammals. Both FPP and adenosine, by modulating the adenylate cyclase (AC)/cAMP signaling pathway , elicit similar biphasic responses
黃伯達;陳思原;趙光漢;陳欽德;何弘能;楊友仕, HUANG, PAI-TA;CHEN, SHEE-UAN;CHAO, KUANG-HAN;CHEN, CHIN-DER;HO, HONG-NERNG;YANG, YU-SHIH   +1 more
core  

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Frog adenosine deaminases.

, 1983
Adenosine deaminase has been shown to consist of three molecular weight forms, A, B, and C. In higher mammals, the A and C forms are dominant while in lower mammals, the B and C forms are dominant.
Cook, Kenneth Steven
core