Results 11 to 20 of about 712,877 (361)
Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer [PDF]
Biomolecules, 2022 The immunosuppressive effect of adenosine in the microenvironment of a tumor is well established. Presently, researchers are developing approaches in immune therapy that target inhibition of adenosine or its signaling such as CD39 or CD73 inhibiting antibodies or adenosine A2A receptor antagonists.
Galina Zhulai +3 more
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Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]
, 2018 Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Born, Willi K +6 more
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Frontiers in Pharmacology, 2017 Adenosine is an ancient extracellular signaling molecule that regulates various biological functions via activating four G-protein-coupled receptors, A1, A2A, A2B, and A3 adenosine receptors. As such, several studies have highlighted a role for adenosine signaling in affecting the T cell development in the thymus. Recent studies indicate that adenosine
Krisztina Köröskényi +5 more
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Squalene-Adenosine Nanoparticles: Ligands of Adenosine Receptors or Adenosine Prodrug? [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Adenosine receptors (ARs) represent key drug targets in many human pathologies, including cardiovascular, neurologic, and inflammatory diseases. To overcome the very rapid metabolization of adenosine, metabolically stable AR agonists and antagonists were developed.
Rouquette, Marie +9 more
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Computerized Modeling of Adenosine Triphosphate, Adenosine Triarsenate and Adenosine Trivanadate [PDF]
Molecules, 2012 Computerized molecular models of adenosine triphosphate, adenosine tri-arsenate and adenosine trivanadate have been generated using the molecular mechanics technique. The analysis of structural parameters indicated that, at least theoretically, adenosine triarsenate is a realistic candidate for replacement of adenosine triphosphate in biochemical ...
Nascimento, Valter A. +2 more
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Journal of Alzheimer's Disease, 2010 Caffeine causes most of its biological effects via antagonizing all types of adenosine receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons and glial cells of all brain areas. In consequence, caffeine, when acting as an AR antagonist, is doing the opposite of activation of adenosine receptors due to removal of ...
Ribeiro, Joaquim A., Sebastião, Ana M
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PHOSPHORYLATION OF MONOACETONE ADENOSINE AND OF DIACETYL ADENOSINE
Journal of Biological Chemistry, 1937 P.A. Levene, R. Stuart Tipson
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Modern Rheumatology, 2009 Adenosine is an endogenous autocoid that regulates a multitude of bodily functions. Its anti-inflammatory actions are well known to rheumatologists since it mediates many of the anti-inflammatory effects of a number of antirheumatic drugs such as methotrexate.
Bruce N. Cronstein, Edwin S. L. Chan
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Current Neuropharmacology, 2009 Over the last several decades the idea that adenosine (Ado) plays a role in sleep control was postulated due in large part to pharmacological studies that showed the ability of Ado agonists to induce sleep and Ado antagonists to decrease sleep. A second wave of research involving in vitro cellular analytic approaches and subsequently, the use of ...
Theresa E. Bjorness, Robert W. Greene
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The adenosinergic signaling in the pathogenesis and treatment of multiple sclerosis
Frontiers in Immunology, 2022 Multiple sclerosis (MS) is a highly disabling, progressive neurodegenerative disease with no curative treatment available. Although significant progress has been made in understanding how MS develops, there remain aspects of disease pathogenesis that are
Eduardo Duarte-Silva +12 more
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