Results 271 to 280 of about 892,163 (354)

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

Nature reviews. Drug discovery, 2006
G. Haskó, J. Linden, B. Cronstein, P. Pacher   +3 more
semanticscholar   +1 more source

Damage response signaling by the extracellular adenosine pathway: control of infection outcome during host aging. [PDF]

mSphere
Bhalla M, Simmons SR, Lenhard A, Betadpur A, Battaglia MC, Bou Ghanem EN.   +5 more
europepmc   +1 more source

Failure of Adenosine-5-Monophosphate to Affect Favorably Pruritus of Atopic Dermatitis1

, 1950
Adolph Rostenberg, Matthew Brunner, J. Murray Riddell   +2 more
openalex   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Tenascin C interacts with Ecto-5′-nucleotidase (eN) and regulates adenosine generation in cancer cells

, 2008
Rafał Sądej, Kunihiro Inai, Zenon Rajfur, Anna Ostapkowicz, Jon Kohler, Andrzej C. Składanowski, Beverly S. Mitchell, Józef Spychała   +7 more
openalex   +1 more source

Lactate Metabolic Reprogramming Mediated by CircRNA–LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer

Advanced Science, EarlyView.
CircSMPD4 physically combines with lactate dehydrogenase A (LDHA) and reduces its acetylation level via SIRT2‐dependent deacetylation, thereby inhibiting chaperone‐mediated autophagy‐lysosome degradation of LDHA. Upregulating LDHA leads to increasing lactate production and extracellular export, which in turn suppresses natural killer cell cytotoxicity ...
Hao Shen, Boqiang Liu, Jing He, Weijun Zhao, Weiqi Li, Lingfeng Ma, Lidan Hou, Yi Wang, Chenqi Jin, Yushun Chang, Jie Lin, Jia Zhao, Binghan Jin, Yuanshi Tian, Xiujun Cai, Liang Shi, Yifan Wang   +16 more
wiley   +1 more source

RNA editing by adenosine deaminases that act on RNA.

Annual Review of Biochemistry, 2002
B. Bass
semanticscholar   +1 more source

Accessory pathway unmasked by adenosine in a patient with unexplained cardiac arrest: a case report. [PDF]

Eur Heart J Case Rep
Taddeucci S, Panchetti L, Nesti M, Garibaldi S.   +3 more
europepmc   +1 more source

Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan‐PKCα‐AKH/AKHR Signaling in Pear Psyllid Morph Transition

Advanced Science, EarlyView.
At 2 5 °C, thermal activation initiates: i) CcIav/CcNan heterotetramer assembly → Ca2⁺ influx; ii) CcPKCα phosphorylation → AKH signaling potentiation; iii) CcAKH1 binding to membrane‐localized CcAKHR → energy mobilization (lipid catabolism/glycogenolysis) and vitellogenin transport via follicular patency; iv) Oocyte maturation → summer‐form nymph ...
Jianying Li, Zhixian Zhang, Yilin Wang, Yue Yang, Jiarui Wang, Xueyi Ruan, Songdou Zhang   +6 more
wiley   +1 more source