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2017
The classic endogenous somnogen adenosine promotes sleep via A1 and A2A receptors. In this chapter, we present an overview of the current knowledge regarding the regulation of adenosine levels, adenosine receptors, and available pharmacologic and genetic tools to manipulate the adenosine system. This is followed by a summary of current knowledge of the
Michael, Lazarus +4 more
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The classic endogenous somnogen adenosine promotes sleep via A1 and A2A receptors. In this chapter, we present an overview of the current knowledge regarding the regulation of adenosine levels, adenosine receptors, and available pharmacologic and genetic tools to manipulate the adenosine system. This is followed by a summary of current knowledge of the
Michael, Lazarus +4 more
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General Pharmacology: The Vascular System, 1996
1. In mammals, nucleoside transport is an important determinant of the pharmacokinetics, plasma and tissue concentration, disposition and in vivo biological activity of adenosine as well as nucleoside analogues used in antiviral and anticancer therapies. 2.
J A, Thorn, S M, Jarvis
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1. In mammals, nucleoside transport is an important determinant of the pharmacokinetics, plasma and tissue concentration, disposition and in vivo biological activity of adenosine as well as nucleoside analogues used in antiviral and anticancer therapies. 2.
J A, Thorn, S M, Jarvis
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1990
Adenosine is a purine nucleoside present in every cell of the human body. It is released into the extracellular space under physiologic and pathophysiologic conditions characterized by increased oxygen demand: supply ratio. Adenosine can exert a wide spectrum of effects in various organs and tissues.
A, Pelleg, R S, Porter
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Adenosine is a purine nucleoside present in every cell of the human body. It is released into the extracellular space under physiologic and pathophysiologic conditions characterized by increased oxygen demand: supply ratio. Adenosine can exert a wide spectrum of effects in various organs and tissues.
A, Pelleg, R S, Porter
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Immunohistochemistry of Adenosine Deaminase: Implications for Adenosine Neurotransmission
Science, 1984Immunohistochemical analysis of adenosine deaminase in rat brain revealed an extensive plexus of adenosine deaminase-containing neurons in the basal hypothalamus. These neurons converged on and were most numerous in three major centers, namely, the tuberal, caudal, and postmammillary caudal magnocellular nuclei.
J I, Nagy +3 more
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[Adenosine and adenosine receptors in the kidney].
Nihon rinsho. Japanese journal of clinical medicine, 1993In the kidney, adenosine plays important regulatory roles, including renal blood flow, glomerular filtration rate, renin secretion, tubuloglomerular feedback, tubular reabsorption of sodium and water, sympathetic neurotransmitter release, and erythropoietin secretion.
S, Umemura +6 more
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Adenosine Diphosphate, Adenosine Triphosphate
1955The increasing importance for animals and bacteria of adenosine diphosphate (ADP) and adenosine triphosphate (ATP) in energy-transfer mechanisms involving such widely diverse processes as muscular contraction, nerve conduction, fire fly luminescence, coenzyme syntheses, tumor growth, polysaccharide synthesis and many other key reactions (McElroy and ...
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2002
Abstract Adenosine is not a neurotransmitter but rather a paracrine neuromodulator. This obviously does not mean that adenosine is not biologically important—it just means that we must think differently about its role compared to, for example, dopamine or noradrenaline.
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Abstract Adenosine is not a neurotransmitter but rather a paracrine neuromodulator. This obviously does not mean that adenosine is not biologically important—it just means that we must think differently about its role compared to, for example, dopamine or noradrenaline.
openaire +2 more sources