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From Oxidative Stress to Bioenergetic Remodeling: Translational Value and Clinical Implications of Exogenous ATP in PARP Inhibitor-Associated Liver Injury [Letter]. [PDF]
Drug Des Devel TherShang M, Ge X.
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Immune checkpoint crosstalk between LAG-3 and CD39/CD73 in glioblastoma: dual-pathway regulation of metabolic exhaustion and therapeutic reversal strategies. [PDF]
J Egypt Natl Canc InstMukherjee A.
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A Postsynthetic Strategy for Oligonucleotides Containing 2-Fluoro-adenine and Isoguanine Nucleobases. [PDF]
Org LettMadaoui M +5 more
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Adenosine and Adenosine Receptors
American Journal of Respiratory Cell and Molecular Biology, 1990In the last decade, there has been renewed interest in extracellular signaling by adenosine and adenine nucleotides. The potent cardiovascular effects of these agents were originally described by Drury and Szent-Gy6rgyi in 1929 (1). This report was followed by a flurry of interest in the use of adenosine as an antihypertensive agent, which subsided ...
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Adenosine and adenosine receptors in colorectal cancer
International Immunopharmacology, 2020CD39 (nucleoside triphosphate diphosphohydrolase) and Ecto-5-nucleotidase (CD73) have been recognized as important factors mediating various pathological and physiological responses in the tumor microenvironment. Elevated expression of CD73 and CD39 is correlated with the over-production of adenosine in the tumor region.
Farnaz, Hajizadeh +7 more
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American Journal of Physiology-Heart and Circulatory Physiology, 1992
Dipyridamole is proposed to increase coronary blood flow (CBF) by inhibition of adenosine uptake into cells, resulting in an increase in interstitial fluid (ISF) adenosine and an adenosine-mediated vasodilation. The purpose of this study was to determine the changes in CBF and ISF adenosine, inosine, and hypoxanthine during dipyridamole infusion in ...
T, Wang, R M, Mentzer, D G, Van Wylen
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Dipyridamole is proposed to increase coronary blood flow (CBF) by inhibition of adenosine uptake into cells, resulting in an increase in interstitial fluid (ISF) adenosine and an adenosine-mediated vasodilation. The purpose of this study was to determine the changes in CBF and ISF adenosine, inosine, and hypoxanthine during dipyridamole infusion in ...
T, Wang, R M, Mentzer, D G, Van Wylen
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General Pharmacology: The Vascular System, 1996
1. In mammals, nucleoside transport is an important determinant of the pharmacokinetics, plasma and tissue concentration, disposition and in vivo biological activity of adenosine as well as nucleoside analogues used in antiviral and anticancer therapies. 2.
J A, Thorn, S M, Jarvis
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1. In mammals, nucleoside transport is an important determinant of the pharmacokinetics, plasma and tissue concentration, disposition and in vivo biological activity of adenosine as well as nucleoside analogues used in antiviral and anticancer therapies. 2.
J A, Thorn, S M, Jarvis
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Cardioprotective actions of adenosine and adenosine analogs
1996Adenosine contributes to the physiological regulation of cardiovascular function and it clearly plays important roles under pathophysiological conditions. The nucleoside functions intracellularly as a major contributor to the general cellular economy and extracellularly as an important signalling molecule.
M A, Cook, M, Karmazyn
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