Results 271 to 280 of about 436,080 (311)

The Role of the Ecto-Nucleotidases CD73 and CD39 in Chemo- and Immunotherapy. [PDF]

Cancers (Basel)
Mucha PT, Brahmachari A, Frańczak MA, Tomczyk M, Kutryb-Zając B, Koszałka P, Giovannetti E, Peters GJ.   +7 more
europepmc   +1 more source

Neurophysiological In Vitro Model of Amyloid-β-Induced Deficits of Hippocampal LTP Involving Neuronal Adenosine A_2A Receptor Dysfunction Through CD73. [PDF]

Cells
Gonçalves FQ, Silva HB, Tomé ÂR, Agostinho P, Cunha RA, Lopes JP.   +5 more
europepmc   +1 more source

A study on the mechanism of Buyang Huanwu Decoction in treating epilepsy by regulating adenosine levels. [PDF]

Sci Rep
Wu S, Deng Y, Yang J, Peng Z, Chen J.
europepmc   +1 more source

Caffeine Exposure Alters Neurotransmission and Stress Physiology in a Freshwater Gastropod. [PDF]

Toxics
Mohamed-Benhamu A.
europepmc   +1 more source

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Adenosine and adenosine receptors in colorectal cancer

International Immunopharmacology, 2020
CD39 (nucleoside triphosphate diphosphohydrolase) and Ecto-5-nucleotidase (CD73) have been recognized as important factors mediating various pathological and physiological responses in the tumor microenvironment. Elevated expression of CD73 and CD39 is correlated with the over-production of adenosine in the tumor region.
Farnaz, Hajizadeh, Ali, Masjedi, Sima, Heydarzedeh Asl, Fariba, Karoon Kiani, Makwan, Peydaveisi, Ghasem, Ghalamfarsa, Farhad, Jadidi-Niaragh, Andrey, Sevbitov   +7 more
openaire   +2 more sources

Adenosine and Adenosine Receptors

American Journal of Respiratory Cell and Molecular Biology, 1990
In the last decade, there has been renewed interest in extracellular signaling by adenosine and adenine nucleotides. The potent cardiovascular effects of these agents were originally described by Drury and Szent-Gy6rgyi in 1929 (1). This report was followed by a flurry of interest in the use of adenosine as an antihypertensive agent, which subsided ...
openaire   +3 more sources

Interstitial adenosine with dipyridamole: effect of adenosine receptor blockade and adenosine deaminase

American Journal of Physiology-Heart and Circulatory Physiology, 1992
Dipyridamole is proposed to increase coronary blood flow (CBF) by inhibition of adenosine uptake into cells, resulting in an increase in interstitial fluid (ISF) adenosine and an adenosine-mediated vasodilation. The purpose of this study was to determine the changes in CBF and ISF adenosine, inosine, and hypoxanthine during dipyridamole infusion in ...
T, Wang, R M, Mentzer, D G, Van Wylen
openaire   +2 more sources

Adenosine Receptors

Annual Review of Physiology, 1992
Our knowledge of A1 and A2ARs has grown dramatically since they were first defined by Burnstock. With the recent purification of the A1AR and the cDNA cloning of the A2AR, an even more rapid expansion of information regarding their structure, function, and regulation should now ensue.
M E, Olah, G L, Stiles
openaire   +2 more sources

Cardioprotective actions of adenosine and adenosine analogs

1996
Adenosine contributes to the physiological regulation of cardiovascular function and it clearly plays important roles under pathophysiological conditions. The nucleoside functions intracellularly as a major contributor to the general cellular economy and extracellularly as an important signalling molecule.
M A, Cook, M, Karmazyn
openaire   +2 more sources

Adenosine and sleep

Sleep Medicine Reviews, 2002
Adenosine is directly linked to the energy metabolism of cells. In the central nervous system an increase in neuronal activity enhances energy consumption as well as extracellular adenosine concentrations. In most brain areas high extracellular adenosine concentrations, through A(1) adenosine receptors, decrease neuronal activity and thus the need for ...
Tarja, Porkka-Heiskanen, Lauri, Alanko, Anna, Kalinchuk, Dag, Stenberg   +3 more
openaire   +2 more sources