Results 301 to 310 of about 617,017 (357)

Adenosine transporters

General Pharmacology: The Vascular System, 1996
1. In mammals, nucleoside transport is an important determinant of the pharmacokinetics, plasma and tissue concentration, disposition and in vivo biological activity of adenosine as well as nucleoside analogues used in antiviral and anticancer therapies. 2.
J A, Thorn, S M, Jarvis
openaire   +2 more sources

Adenosine signaling and the immune system: When a lot could be too much.

Immunology Letters, 2019
Adenosine is increasingly recognized as a key mediator of the immune response. Signals delivered by extracellular adenosine are detected and transduced by G-protein-coupled cell-surface receptors, classified into four subtypes: A1, A2A, A2B and A3. These
L. Antonioli, M. Fornai, C. Blandizzi, P. Pacher, G. Haskó   +4 more
semanticscholar   +1 more source

Adenosine and adenosine receptors in colorectal cancer

International Immunopharmacology, 2020
CD39 (nucleoside triphosphate diphosphohydrolase) and Ecto-5-nucleotidase (CD73) have been recognized as important factors mediating various pathological and physiological responses in the tumor microenvironment. Elevated expression of CD73 and CD39 is correlated with the over-production of adenosine in the tumor region.
Farnaz, Hajizadeh, Ali, Masjedi, Sima, Heydarzedeh Asl, Fariba, Karoon Kiani, Makwan, Peydaveisi, Ghasem, Ghalamfarsa, Farhad, Jadidi-Niaragh, Andrey, Sevbitov   +7 more
openaire   +2 more sources

Targeting the CD73-adenosine axis in immuno-oncology.

Immunology Letters, 2019
The ectonucleotidases CD39 and CD73 are cell surface enzymes that catabolize the breakdown of extracellular ATP into adenosine. As such, they constitute critical components of the extracellular purinergic pathway and play important roles in maintaining ...
D. Allard, P. Chrobak, B. Allard, Nouredin Messaoudi, J. Stagg   +4 more
semanticscholar   +1 more source

Adenosine Diphosphate, Adenosine Triphosphate

1955
The increasing importance for animals and bacteria of adenosine diphosphate (ADP) and adenosine triphosphate (ATP) in energy-transfer mechanisms involving such widely diverse processes as muscular contraction, nerve conduction, fire fly luminescence, coenzyme syntheses, tumor growth, polysaccharide synthesis and many other key reactions (McElroy and ...
openaire   +1 more source

Interstitial adenosine with dipyridamole: effect of adenosine receptor blockade and adenosine deaminase

American Journal of Physiology-Heart and Circulatory Physiology, 1992
Dipyridamole is proposed to increase coronary blood flow (CBF) by inhibition of adenosine uptake into cells, resulting in an increase in interstitial fluid (ISF) adenosine and an adenosine-mediated vasodilation. The purpose of this study was to determine the changes in CBF and ISF adenosine, inosine, and hypoxanthine during dipyridamole infusion in ...
T, Wang, R M, Mentzer, D G, Van Wylen
openaire   +2 more sources

Adenosine receptors

2002
Abstract Adenosine is not a neurotransmitter but rather a paracrine neuromodulator. This obviously does not mean that adenosine is not biologically important—it just means that we must think differently about its role compared to, for example, dopamine or noradrenaline.
openaire   +2 more sources

Cardioprotective actions of adenosine and adenosine analogs

1996
Adenosine contributes to the physiological regulation of cardiovascular function and it clearly plays important roles under pathophysiological conditions. The nucleoside functions intracellularly as a major contributor to the general cellular economy and extracellularly as an important signalling molecule.
M A, Cook, M, Karmazyn
openaire   +2 more sources

The adenosine pathway in immuno-oncology

Nature Reviews Clinical Oncology, 2020
B. Allard, D. Allard, L. Buisseret, J. Stagg   +3 more
semanticscholar   +1 more source

Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

Nature, 1962
G. Born
semanticscholar   +1 more source