Results 31 to 40 of about 734,488 (357)
PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine
Molecular Pain, 2011 Background Prostatic acid phosphatase (PAP) and ecto-5'-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main ...
Vihko Pirkko +7 more
doaj +1 more source
Frontiers in Pharmacology, 2020 It is well established that altered purinergic signaling contributes to vascular dysfunction in type 2 diabetes (T2D). Red blood cells (RBCs) serve as an important pool for circulating ATP and the release of ATP from RBCs in response to physiological ...
Ali Mahdi +9 more
doaj +1 more source
The CD73 immune checkpoint promotes tumor cell metabolic fitness
eLife, 2023 CD73 is an ectonucleotidase overexpressed on tumor cells that suppresses anti-tumor immunity. Accordingly, several CD73 inhibitors are currently being evaluated in the clinic, including in large randomized clinical trials.
David Allard +6 more
doaj +1 more source
Stability of diluted adenosine solutions in polyvinyl chloride infusion bags [PDF]
, 2011 Purpose The stability of diluted adenosine solutions in polyvinyl chloride infusion bags was studied. Methods Adenosine 50-, 100-, and 220-μg/mL solutions were prepared in 50-mL polyvinyl chloride (PVC) infusion bags containing 0.9% sodium chloride ...
Bollinger, Jessica E. +3 more
core +2 more sources
The role of adenosine in preconditioning by brief pressure overload in rats
Journal of the Formosan Medical Association, 2015 Brief pressure overload of the left ventricle reduced myocardial infarct (MI) size in rabbits has been previously reported. Its effects in other species are not known. This study investigates effects of pressure overload and the role of adenosine in rats
Cheng-Hsiung Huang +4 more
doaj +1 more source
Comparison between adenosine triphosphate bioluminescence and aerobic colony count to assess surface sanitation in the hospital environment [PDF]
, 2018 Background: Adenosine triphosphate bioluminescence produced by the firefly luciferase has been successfully introduced to verify cleaning procedures in the food industry according to the Hazard Analysis Critical Control Point program.
Alagna E. +8 more
core +1 more source
Extracellular adenosine triphosphate and adenosine in cancer [PDF]
Oncogene, 2010 Adenosine triphosphate (ATP) is actively released in the extracellular environment in response to tissue damage and cellular stress. Through the activation of P2X and P2Y receptors, extracellular ATP enhances tissue repair, promotes the recruitment of immune phagocytes and dendritic cells, and acts as a co-activator of NLR family, pyrin domain ...
Stagg, J., Smyth, M. J.
openaire +3 more sources
Frontiers in Neurology, 2019 Epilepsy is a neurological disorder characterized by a long term propensity to produce unprovoked seizures and by the associated comorbidities including neurological, cognitive, psychiatric, and impairment the quality of life.
Fan Chen +3 more
doaj +1 more source
PharmaceuticalsGlioblastoma (GB) is the most aggressive and common primary malignant tumor of the brain and central nervous system. Without treatment, the average patient survival time is about six months, which can be extended to fifteen months with multimodal ...
Liuba Peñate +9 more
doaj +1 more source
Meta-analysis of death and myocardial infarction in the DEFINE-FLAIR and iFR-SWEDEHEART trials: a hypothesis generating note of caution [PDF]
, 2017 In patients with coronary heart disease, revascularization can improve symptoms and in certain high-risk subgroups may improve prognosis. Coronary angiography provides anatomical information and the physiological significance of a stenosis can be ...
Berry, Colin +2 more
core +1 more source