Results 31 to 40 of about 731,675 (357)

Stimulation of endothelial adenosine Al receptors enhances adhesion of neutrophils in the intact guinea pig coronary system [PDF]

, 1994
Objective: The primary aim was to determine the action of pathophysiologically relevant adenosine concentrations (0.1-1 μM) on adhesion of neutrophils to coronary endothelium.
Becker, Bernhard F., Gerlach, E., Raschke, P., Zahler, Stefan   +3 more
core   +1 more source

PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine

Molecular Pain, 2011
Background Prostatic acid phosphatase (PAP) and ecto-5'-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main ...
Vihko Pirkko, Guillot Thomas S, Taylor-Blake Bonnie, Sowa Nathaniel A, Walsh Paul L, Street Sarah E, Wightman R Mark, Zylka Mark J   +7 more
doaj   +1 more source

Erythrocytes Induce Endothelial Injury in Type 2 Diabetes Through Alteration of Vascular Purinergic Signaling

Frontiers in Pharmacology, 2020
It is well established that altered purinergic signaling contributes to vascular dysfunction in type 2 diabetes (T2D). Red blood cells (RBCs) serve as an important pool for circulating ATP and the release of ATP from RBCs in response to physiological ...
Ali Mahdi, Yahor Tratsiakovich, John Tengbom, Tong Jiao, Lara Garib, Michael Alvarsson, Jiangning Yang, John Pernow, John Pernow, Zhichao Zhou   +9 more
doaj   +1 more source

The CD73 immune checkpoint promotes tumor cell metabolic fitness

eLife, 2023
CD73 is an ectonucleotidase overexpressed on tumor cells that suppresses anti-tumor immunity. Accordingly, several CD73 inhibitors are currently being evaluated in the clinic, including in large randomized clinical trials.
David Allard, Isabelle Cousineau, Eric H Ma, Bertrand Allard, Yacine Bareche, Hubert Fleury, John Stagg   +6 more
doaj   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source

The role of adenosine in preconditioning by brief pressure overload in rats

Journal of the Formosan Medical Association, 2015
Brief pressure overload of the left ventricle reduced myocardial infarct (MI) size in rabbits has been previously reported. Its effects in other species are not known. This study investigates effects of pressure overload and the role of adenosine in rats
Cheng-Hsiung Huang, Shen-Kou Tsai, Shu-Chiung Chiang, Chang-Chi Lai, Zen-Chung Weng   +4 more
doaj   +1 more source

Extracellular adenosine triphosphate and adenosine in cancer [PDF]

Oncogene, 2010
Adenosine triphosphate (ATP) is actively released in the extracellular environment in response to tissue damage and cellular stress. Through the activation of P2X and P2Y receptors, extracellular ATP enhances tissue repair, promotes the recruitment of immune phagocytes and dendritic cells, and acts as a co-activator of NLR family, pyrin domain ...
Stagg, J., Smyth, M. J.
openaire   +3 more sources

Meta-analysis of death and myocardial infarction in the DEFINE-FLAIR and iFR-SWEDEHEART trials: a hypothesis generating note of caution [PDF]

, 2017
In patients with coronary heart disease, revascularization can improve symptoms and in certain high-risk subgroups may improve prognosis. Coronary angiography provides anatomical information and the physiological significance of a stenosis can be ...
Berry, Colin, McClure, John D., Oldroyd, Keith G.   +2 more
core   +1 more source

Role of DNA Methylation and Adenosine in Ketogenic Diet for Pharmacoresistant Epilepsy: Focus on Epileptogenesis and Associated Comorbidities

Frontiers in Neurology, 2019
Epilepsy is a neurological disorder characterized by a long term propensity to produce unprovoked seizures and by the associated comorbidities including neurological, cognitive, psychiatric, and impairment the quality of life.
Fan Chen, Xinghui He, Guoming Luan, Tianfu Li   +3 more
doaj   +1 more source

The Impact of A3AR Antagonism on the Differential Expression of Chemoresistance-Related Genes in Glioblastoma Stem-like Cells

Pharmaceuticals
Glioblastoma (GB) is the most aggressive and common primary malignant tumor of the brain and central nervous system. Without treatment, the average patient survival time is about six months, which can be extended to fifteen months with multimodal ...
Liuba Peñate, Diego Carrillo-Beltrán, Carlos Spichiger, Alexei Cuevas-Zhbankova, Ángelo Torres-Arévalo, Pamela Silva, Hans G. Richter, Ángel Ayuso-Sacido, Rody San Martín, Claudia Quezada-Monrás   +9 more
doaj   +1 more source