Results 31 to 40 of about 617,017 (357)

Extracellular adenosine triphosphate and adenosine in cancer [PDF]

Oncogene, 2010
Adenosine triphosphate (ATP) is actively released in the extracellular environment in response to tissue damage and cellular stress. Through the activation of P2X and P2Y receptors, extracellular ATP enhances tissue repair, promotes the recruitment of immune phagocytes and dendritic cells, and acts as a co-activator of NLR family, pyrin domain ...
Stagg, J., Smyth, M. J.
openaire   +3 more sources

The Impact of A3AR Antagonism on the Differential Expression of Chemoresistance-Related Genes in Glioblastoma Stem-like Cells

Pharmaceuticals
Glioblastoma (GB) is the most aggressive and common primary malignant tumor of the brain and central nervous system. Without treatment, the average patient survival time is about six months, which can be extended to fifteen months with multimodal ...
Liuba Peñate, Diego Carrillo-Beltrán, Carlos Spichiger, Alexei Cuevas-Zhbankova, Ángelo Torres-Arévalo, Pamela Silva, Hans G. Richter, Ángel Ayuso-Sacido, Rody San Martín, Claudia Quezada-Monrás   +9 more
doaj   +1 more source

Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

Nature Communications, 2019
Potentiation of neutrophil extracellular trap (NET) release is one mechanism by which antiphospholipid antibodies (aPL Abs) effect thrombotic events in patients with antiphospholipid syndrome (APS).
R. Ali, Alex A. Gandhi, He Meng, S. Yalavarthi, Andrew P. Vreede, S. Estes, Olivia R. Palmer, P. Bockenstedt, D. Pinsky, J. Greve, J. Diaz, Y. Kanthi, J. Knight   +12 more
semanticscholar   +1 more source

Exacerbation of Allergic Airway Inflammation in Mice Lacking ECTO-5′-Nucleotidase (CD73)

Frontiers in Pharmacology, 2020
The airways are a target tissue of type I allergies and atopy is the main etiological factor of bronchial asthma. A predisposition to allergy and individual response to allergens are dependent upon environmental and host factors.
Elisabetta Caiazzo, Ida Cerqua, Maria Antonietta Riemma, Roberta Turiello, Roberta Turiello, Armando Ialenti, Jurgen Schrader, Giuseppe Fiume, Carmen Caiazza, Fiorentina Roviezzo, Silvana Morello, Carla Cicala   +11 more
doaj   +1 more source

Adenosine Receptors Profile in Fibromuscular Dysplasia

Biomedicines, 2022
Fibromuscular dysplasia (FMD) is a non-inflammatory vascular disease that is characterized by unexplained systemic hypertension occurring in young people, associated with arterial stenosis, aneurysm rupture, intracranial/renal infarction, and stroke ...
Claire Guiol, Sarah El Harake, Julien Fromonot, Mohamed Chefrour, Marguerite Gastaldi, Yassine Alibouch, Maxime Doublier, Pierre Deharo, Gabrielle Sarlon, Marion Marlinge, Nathalie Lalevee, Régis Guieu, François Silhol   +12 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine

Molecular Pain, 2011
Background Prostatic acid phosphatase (PAP) and ecto-5'-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main ...
Vihko Pirkko, Guillot Thomas S, Taylor-Blake Bonnie, Sowa Nathaniel A, Walsh Paul L, Street Sarah E, Wightman R Mark, Zylka Mark J   +7 more
doaj   +1 more source

Erythrocytes Induce Endothelial Injury in Type 2 Diabetes Through Alteration of Vascular Purinergic Signaling

Frontiers in Pharmacology, 2020
It is well established that altered purinergic signaling contributes to vascular dysfunction in type 2 diabetes (T2D). Red blood cells (RBCs) serve as an important pool for circulating ATP and the release of ATP from RBCs in response to physiological ...
Ali Mahdi, Yahor Tratsiakovich, John Tengbom, Tong Jiao, Lara Garib, Michael Alvarsson, Jiangning Yang, John Pernow, John Pernow, Zhichao Zhou   +9 more
doaj   +1 more source

The CD73 immune checkpoint promotes tumor cell metabolic fitness

eLife, 2023
CD73 is an ectonucleotidase overexpressed on tumor cells that suppresses anti-tumor immunity. Accordingly, several CD73 inhibitors are currently being evaluated in the clinic, including in large randomized clinical trials.
David Allard, Isabelle Cousineau, Eric H Ma, Bertrand Allard, Yacine Bareche, Hubert Fleury, John Stagg   +6 more
doaj   +1 more source

Research progress on adenosine in central nervous system diseases

CNS Neuroscience & Therapeutics, 2019
As an endogenous neuroprotectant agent, adenosine is extensively distributed and is particularly abundant in the central nervous system (CNS). Under physiological conditions, the concentration of adenosine is low intra‐ and extracellularly, but increases
Yingjiao Liu, Jiao Chen, Xun Li, Xin Zhou, Yaomei Hu, Shi-Feng Chu, Ye Peng, N. Chen   +7 more
semanticscholar   +1 more source