Results 31 to 40 of about 559,924 (346)

Targeting adenosine for cancer immunotherapy

Journal of Immunotherapy for Cancer, 2018
Immune checkpoint antagonists (CTLA-4 and PD-1/PD-L1) and CAR T-cell therapies generate unparalleled durable responses in several cancers and have firmly established immunotherapy as a new pillar of cancer therapy.
R. Leone, L. Emens
semanticscholar   +1 more source

Adenosine A2A Receptor Signaling in the Immunopathogenesis of Experimental Autoimmune Encephalomyelitis

Frontiers in Immunology, 2018
Our increasing appreciation of adenosine as an endogenous signaling molecule that terminates inflammation has generated excitement regarding the potential to target adenosine receptors (ARs) in the treatment of multiple sclerosis (MS), a disease of ...
Skanda Rajasundaram
doaj   +1 more source

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function

Frontiers in Immunology, 2019
T cells play a critical role in cancer control, but a range of potent immunosuppressive mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their activity.
S. Viganó, Dimitrios Alatzoglou, M. Irving, C. Ménétrier-Caux, C. Caux, P. Romero, G. Coukos   +6 more
semanticscholar   +1 more source

Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade

Journal for ImmunoTherapy of Cancer, 2020
Background PD1/PDL1-directed therapies have been unsuccessful for multiple myeloma (MM), an incurable cancer of plasma cells in the bone marrow (BM). Therefore, other immune checkpoints such as extracellular adenosine and its immunosuppressive receptor ...
Rui Yang, Samah Elsaadi, K. Misund, Pegah Abdollahi, Esten N Vandsemb, S. Moen, Anna Kuśnierczyk, G. Slupphaug, T. Standal, A. Waage, T. Slørdahl, T. B. Rø, E. Rustad, A. Sundan, Carl M. Hay, Z. Cooper, A. Schuller, R. Woessner, A. Borodovsky, E. Menu, M. Børset, A. Sponaas   +21 more
semanticscholar   +1 more source

An Advanced in Silico Modelling of the Interaction between FSCPX, an Irreversible A₁ Adenosine Receptor Antagonist, and NBTI, a Nucleoside Transport Inhibitor, in the Guinea Pig Atrium

Molecules, 2019
In earlier studies, we generated concentration-response (E/c) curves with CPA (N6-cyclopentyladenosine; a selective A1 adenosine receptor agonist) or adenosine, in the presence or absence of S-(2-hydroxy-5-nitrobenzyl)-6-thioinosine (NBTI, a selective ...
Adrienn Monika Szabo, Tamas Erdei, Gabor Viczjan, Rita Kiss, Judit Zsuga, Csaba Papp, Akos Pinter, Bela Juhasz, Zoltan Szilvassy, Rudolf Gesztelyi   +9 more
doaj   +1 more source

A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment.

Cancer Research, 2018
Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of cytotoxic lymphocytes and impairs antitumor immune responses.
A. Young, S. Ngiow, Yulong Gao, A. Patch, Deborah S. Barkauskas, M. Messaoudene, G. Lin, J. Coudert, Kimberley A Stannard, L. Zitvogel, M. Degli-Esposti, É. Vivier, N. Waddell, J. Linden, N. Huntington, F. Souza-Fonseca-Guimaraes, M. Smyth   +16 more
semanticscholar   +1 more source

Adenosine and Migraine [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1998
ABSTRACT:Background:Adenosine is a powerful natural vasodilator that participates in the control of cerebral and meningeal blood flow. In this context, it could be involved in the pathophysiology of migraine, since it was previously reported that intravenous adenosine can precipitate crises in migraine patients.Methods:We have investigated circulating ...
R. Gola, H. Henry, Hervé Rochat, G. Bechis, Régis Guieu, Marianick Juin, Jean Pouget, D. Mallet, Christiane Devaux, F. Sampieri   +9 more
openaire   +3 more sources

Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions

Marine Drugs, 2017
Deep ocean water (DOW) has been shown to enhance the functional components of fungi, resulting in increased health benefits. Therefore, using DOW for culturing fungi can enhance the cordycepin and adenosine of Cordyceps militaris (CM) and its protective ...
Yu-Ping Hung, Chun-Lin Lee
doaj   +1 more source

Tumor-infiltrating CD39+ γδTregs are novel immunosuppressive T cells in human colorectal cancer

OncoImmunology, 2017
Tumor microenvironment (TME) promotes immune suppression through recruiting and expanding suppressive immune cells such as regulatory T cells (Tregs) to facilitate cancer progression.
Guoming Hu, Pin Wu, Pu Cheng, Zhigang Zhang, Zhen Wang, Xiuyan Yu, Xuan Shao, Dang Wu, Jun Ye, Tao Zhang, Xiaochen Wang, Fuming Qiu, Jun Yan, Jian Huang   +13 more
doaj   +1 more source

A protein binding assay for adenosine 3':5'-cyclic monophosphate.

Proceedings of the National Academy of Sciences of the United States of America, 1970
A simple and sensitive assay for adenosine 3':5'-cyclic monophosphate (cAMP) has been developed that is based on competition for protein binding of the nucleotide, presumably to a cAMP-dependent protein kinase.
A. Gilman
semanticscholar   +1 more source