Results 181 to 190 of about 68,176 (222)

The A1 adenosine receptor as a new player in microglia physiology

Glia, 2013
The purinergic system is highly involved in the regulation of microglial physiological processes. In addition to the accepted roles for the P2X4,7 and P2Y12 receptors activated by adenosine triphosphate (ATP) and adenosine diphosphate, respectively, recent evidence suggests a role for the adenosine A2A receptor in microglial cytoskeletal rearrangements.
LUONGO, Livio, GUIDA, Francesca, Imperatore R, Napolitano F, Gatta L, Cristino L, Giordano C, Siniscalco D, Di Marzo V, BELLINI, Giulia, Petrelli R, Cappellacci L, USIELLO, Alessandro, DE NOVELLIS, Vito, ROSSI, Francesca, MAIONE, Sabatino   +15 more
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Alterations of adenosine A1 receptors in morphine dependence

Brain Research, 1994
The possibility that central adenosine A1 and A2a receptors mediate opiate dependence was examined in morphine-treated mice using radioligand binding methods. Mice treated with morphine for 72 h demonstrated significant increases in naloxone precipitated abstinence behaviors of jumping, wet-dog shakes, teeth chattering, forepaw trends, forepaw tremors ...
Gary B. Kaplan, Kimberly A Leite-Morris, Mary T. Sears   +2 more
openaire   +3 more sources

Medicinal Chemistry of Adenosine A1 Receptor Ligands

Current Topics in Medicinal Chemistry, 2003
In this review the latest developments in ligand design for the adenosine A(1) receptor are summarized. Novel series of agonists and antagonists are discussed, leading to the conclusion that ligands truly selective for the human adenosine A(1) receptor are still scarce.
Ad P. IJzerman, Ineke Van Wijngaarden, Willem Soudijn   +2 more
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The structure and function of A1 and A2B adenosine receptors

Life Sciences, 1998
Of the four G protein coupled adenosine receptor (AR) subtypes, the A1 is best suited for studies of reconstitution with G proteins. Recombinant A1 receptors extended with hexahistidine and FLAG have been purified to near homogeneity. In reconstitution assays using pure recombinant G protein subunits, the composition of the gamma subunit influences ...
Joel Linden, Robert A. Figler, John A. Auchampach, Xiaowei Jin   +3 more
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Effects of enprofylline on A1 and A2 adenosine receptors

European Journal of Pharmacology, 1985
The effects of enprofylline were studied on A1 adenosine receptors of rat fat cells and on A2 adenosine receptors of human platelets and of guinea-pig lung. Enprofylline antagonized the 5'-N-ethylcarboxamidoadenosine (NECA)-induced stimulation of platelet adenylate cyclase activity with a KB of 130 microM.
Ulrich Schwabe, Dieter Ukena, Carl Georg Schirren   +2 more
openaire   +3 more sources

A “locked-on,” constitutively active mutant of the adenosine A1 receptor

European Journal of Pharmacology, 2005
We studied the wild-type human adenosine A1 receptor and three mutant receptors, in which the glycine at position 14 had been changed into an alanine, a leucine, or a threonine residue. All receptors were characterized in radioligand binding experiments, the wild-type and the Gly14Thr mutant receptor in greater detail.
Rob Leurs, Anna Lorenzen, Rianne A.F. de Ligt, Ad P. IJzerman, Scott A. Rivkees   +4 more
openaire   +4 more sources

Affinity chromatography in purification of A1 adenosine receptors

Journal of Chromatography A, 1992
Purification of A1 adenosine receptor of rat brain membranes was performed using a newly developed affinity gel employing xanthine amine congener (XAC) as an immobilized ligand. The A1 adenosine receptor was solubilized with digitonin-cholate from brain membranes and then purified by a sequential use of affinity chromatography on XAC-agarose ...
openaire   +3 more sources

Modulation of A1 adenosine receptor signaling by peroxynitrite

Biochemical Pharmacology, 2004
Nitric oxide (NO) is a gaseous free radical involved in many pathophysiological processes. During oxidative stress, NO, its derivatives and adenosine are released. Considering adenosine neuroprotective role in the central nervous system (CNS) and toxicity of NO, we investigated the effect of a NO/peroxynitrite (ONOO(-)) donor, 3-morpholinosydnonimine ...
Giuntini J, GIUSTI, LAURA, LUCACCHINI, ANTONIO, MAZZONI, MARIA ROSA   +3 more
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A1 Adenosine Receptor: Role in Diabetes and Obesity

2009
Adenosine mediates its diverse effects via four subtypes (A(1), A(2A), A(2B) and A(3)) of G-protein-coupled receptors. The A(1) adenosine receptor (A(1)AR) subtype is the most extensively studied and is well characterized in various organ systems. The A(1)ARs are highly expressed in adipose tissue, and endogenous adenosine has been shown to tonically ...
Jeffrey W. Chisholm, Luiz Belardinelli, Gerald M. Reaven, Arvinder K. Dhalla   +3 more
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Adenosine A1-receptor occupancy predicts A1-receptor antagonist effects of N-0861*

Clinical Pharmacology & Therapeutics, 1998
To evaluate the relationship between dose of N-0861 ([+/-]N6-endo-norbornan-2-yl-9-methyladenine), N-0861 plasma concentrations, and antagonism of adenosine-induced slowing of atrioventricular nodal conduction and to evaluate A1-receptor occupancy by antagonist present in plasma of subjects after administration of N-0861 to determine A1-selectivity of ...
Satoru Nagashima, Robert E. Benton, Sally Usdin Yasuda, Jean T. Barbey, Erwin Douyon, Raymond L. Woosley   +5 more
openaire   +2 more sources