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Adenosine A1 receptor antagonism prevents DSI in hippocampal CA1 pyramidal cells: PS077. [PDF]
Porto Biomed J, 2017 Freire J, Rombo DM, Sebastião AM.
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Synthesis of novel (benzimidazolyl)isoquinolinols and evaluation as adenosine A1 receptor tools. [PDF]
RSC Adv, 2018 Singh S +8 more
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Adenosine-A1 receptor agonist induced hyperalgesic priming type II. [PDF]
Pain, 2016 Araldi D, Ferrari LF, Levine JD.
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Adenosine A1 receptor antagonists and the kidney
Current Opinion in Nephrology and Hypertension, 2003This review will examine the most recent evidence that adenosine receptors in the kidney can alter kidney function. Adenosine A(1)-receptors located in the afferent arteriole and proximal tubule can contribute to fluid retaining disorders by mediating tubuloglomerular feedback, afferent arteriole vasoconstriction or direct sodium absorption.
P. Modlinger, W. Welch
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The glycoprotein nature of A1 adenosine receptors [PDF]
Biochemical and Biophysical Research Communications, 1986 A1 adenosine receptors from different tissues and species were photoaffinity labelled and then the carbohydrate content was examined by both enzymatic and chemical treatment. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the labelled membrane receptors shows that neuraminidase treatment alters the electrophoretic mobility of the receptor
Klotz, Karl-Norbert, Lohse, M. J.
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Allosteric modulators for the A1 adenosine receptor
Expert Opinion on Therapeutic Patents, 2004The present invention provides compounds of formula (I) wherein R1, R2, R3, R4 and Q have a meaning as defined herein in the specification. The compounds of formula (I) are allosteric modulators of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor.
BARALDI, Pier Giovanni +4 more
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Adenosine A1 receptors and erythropoietin production
American Journal of Physiology-Cell Physiology, 1993N6-cyclopentyladenosine (CPA), a selective adenosine A1 receptor agonist, in a concentration range of 10(-9) to 10(-7) M, produced a significant decrease in erythropoietin (EPO) levels in a human hepatocellular carcinoma (Hep G2) cell culture (medium levels of EPO, 91.81 +/- 1.61 and 94.36 +/- 0.97% of control, respectively) after 24 h incubation in a
James W. Fisher +2 more
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European Journal of Pharmacology, 1997
The pineal organ of vertebrates produces melatonin and adenosine. In lower vertebrates, adenosine modulates melatonin production. We report herein that 2-chloro-cyclopentyl-[3H]-adenosine ([3H]CCPA: adenosine A1 receptor agonist) and [3H]-cyclopentyl-1,3-dipropylxanthine ([3H]DPCPX: adenosine A1 receptor antagonist), bind specifically to sheep pineal ...
Jack Falcón +3 more
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The pineal organ of vertebrates produces melatonin and adenosine. In lower vertebrates, adenosine modulates melatonin production. We report herein that 2-chloro-cyclopentyl-[3H]-adenosine ([3H]CCPA: adenosine A1 receptor agonist) and [3H]-cyclopentyl-1,3-dipropylxanthine ([3H]DPCPX: adenosine A1 receptor antagonist), bind specifically to sheep pineal ...
Jack Falcón +3 more
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Binding thermodynamics at A1 and A2a adenosine receptors
Life Sciences, 1996Only recently the binding equilibrium of a number of ligands at adenosine A1 and A2a receptors has been analyzed from a thermodynamic point of view. This approach presents the advantage, with respect to usual affinity constant measurements, of a greater capability to give information about the molecular mechanisms underlying the binding process.
BOREA, Pier Andrea +4 more
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The role of adenosine A1 receptor on immune cells
Inflammation Research, 2022Adenosine, acting as a regulator by mediating the activation of G protein-coupled adenosine receptor families (A1, A2A, A2B, and A3), plays an important role under physiological and pathological conditions. As the receptor with the highest affinity for adenosine, the role of adenosine A1 receptor (A1R)-mediated adenosine signaling pathway in the ...
Lingyu, Zhong, Qiao, Peng, Xun, Zeng
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