Results 311 to 320 of about 124,204 (359)

Alterations of adenosine A1 receptors in morphine dependence

Brain Research, 1994
The possibility that central adenosine A1 and A2a receptors mediate opiate dependence was examined in morphine-treated mice using radioligand binding methods. Mice treated with morphine for 72 h demonstrated significant increases in naloxone precipitated abstinence behaviors of jumping, wet-dog shakes, teeth chattering, forepaw trends, forepaw tremors ...
Gary B. Kaplan, Kimberly A Leite-Morris, Mary T. Sears   +2 more
openaire   +3 more sources

New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.

Journal of Medicinal Chemistry, 2007
Fluorescence spectroscopy is becoming a valuable addition to the array of techniques available for scrutinizing ligand-receptor interactions in biological systems. In particular, scanning confocal microscopy and fluorescence correlation spectroscopy (FCS)
R. Middleton, S. Briddon, Y. Cordeaux, A. Yates, Clare L. Dale, M. George, J. Baker, S. Hill, B. Kellam   +8 more
semanticscholar   +1 more source

A “locked-on,” constitutively active mutant of the adenosine A1 receptor

European Journal of Pharmacology, 2005
We studied the wild-type human adenosine A1 receptor and three mutant receptors, in which the glycine at position 14 had been changed into an alanine, a leucine, or a threonine residue. All receptors were characterized in radioligand binding experiments, the wild-type and the Gly14Thr mutant receptor in greater detail.
Rob Leurs, Anna Lorenzen, Rianne A.F. de Ligt, Ad P. IJzerman, Scott A. Rivkees   +4 more
openaire   +4 more sources

Adenosine improves recovery of postischemic myocardial function via an adenosine A1 receptor mechanism.

American Journal of Physiology, 1992
The effects of adenosine in the nonischemic heart have been shown to be mediated via its binding to extracellular adenosine A1 and A2 receptors located predominantly on myocytes and endothelial cells, respectively.
R. Lasley, Robert M. Mentzer
semanticscholar   +1 more source

Affinity chromatography in purification of A1 adenosine receptors

Journal of Chromatography A, 1992
Purification of A1 adenosine receptor of rat brain membranes was performed using a newly developed affinity gel employing xanthine amine congener (XAC) as an immobilized ligand. The A1 adenosine receptor was solubilized with digitonin-cholate from brain membranes and then purified by a sequential use of affinity chromatography on XAC-agarose ...
openaire   +3 more sources

Modulation of A1 adenosine receptor signaling by peroxynitrite

Biochemical Pharmacology, 2004
Nitric oxide (NO) is a gaseous free radical involved in many pathophysiological processes. During oxidative stress, NO, its derivatives and adenosine are released. Considering adenosine neuroprotective role in the central nervous system (CNS) and toxicity of NO, we investigated the effect of a NO/peroxynitrite (ONOO(-)) donor, 3-morpholinosydnonimine ...
Giuntini J, GIUSTI, LAURA, LUCACCHINI, ANTONIO, MAZZONI, MARIA ROSA   +3 more
openaire   +4 more sources

A1 Adenosine Receptor: Role in Diabetes and Obesity

2009
Adenosine mediates its diverse effects via four subtypes (A(1), A(2A), A(2B) and A(3)) of G-protein-coupled receptors. The A(1) adenosine receptor (A(1)AR) subtype is the most extensively studied and is well characterized in various organ systems. The A(1)ARs are highly expressed in adipose tissue, and endogenous adenosine has been shown to tonically ...
Jeffrey W. Chisholm, Luiz Belardinelli, Gerald M. Reaven, Arvinder K. Dhalla   +3 more
openaire   +3 more sources

Adenosine A1-receptor occupancy predicts A1-receptor antagonist effects of N-0861*

Clinical Pharmacology & Therapeutics, 1998
To evaluate the relationship between dose of N-0861 ([+/-]N6-endo-norbornan-2-yl-9-methyladenine), N-0861 plasma concentrations, and antagonism of adenosine-induced slowing of atrioventricular nodal conduction and to evaluate A1-receptor occupancy by antagonist present in plasma of subjects after administration of N-0861 to determine A1-selectivity of ...
Satoru Nagashima, Robert E. Benton, Sally Usdin Yasuda, Jean T. Barbey, Erwin Douyon, Raymond L. Woosley   +5 more
openaire   +2 more sources

A1 Adenosine Receptors in Human Neutrophils

1998
Adenosine is an ubiquitous nucleoside that mediates several important physiological effects, trough the binding of three pharmacologically distinct receptor subtypes, named A1 A2 and A 3 .1 Adenosine receptor subtypes has been distinguished on the basis of the effect of adenosine on the cellular content of cAMP: occupancy of A2 adenosine receptors ...
MARTINI, CLAUDIA, TRINCAVELLI, MARIA LETIZIA, FIORINI M., SALVETTI F., MONTALI, UMBERTO, FALLENI, ALESSANDRA, GREMIGNI V., LUCACCHINI, ANTONIO   +7 more
openaire   +4 more sources

Adenosine attenuates calcium paradox injury: role of adenosine A1 receptor

American Journal of Physiology-Cell Physiology, 1995
The present study was conducted to test the hypothesis that adenosine attenuates the Ca2+ paradox (PD) injury via stimulation of adenosine A1 receptors linked to Gi proteins in the isolated rat heart. Treatment of adenosine reduced maximum lactate dehydrogenase release and ATP loss compared with regular Ca2+ PD.
J. Suleiman, M. Ashraf
openaire   +3 more sources