Results 321 to 330 of about 124,204 (359)
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2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.
Journal of Medicinal Chemistry, 2004Adenosine receptor antagonists usually possess a bi- or tricyclic heteroaromatic structure at their core with varying substitution patterns to achieve selectivity and/or greater affinity.
Lisa C W Chang +7 more
semanticscholar +1 more source
Evidence of A1 Adenosine Receptor on Epidydimal Bovine Spermatozoa
Archives of Biochemistry and Biophysics, 19953H-R-phenylisopropyladenosine (PIA) was used to characterize adenosine receptors on bovine epidydimal spermatozoa membranes. Dypiridamole, an adenosine uptake inhibitor, did not effect the radioligand binding, indicating an external site for the interaction of adenosine with spermatozoa.
MINELLI, Alba +3 more
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Desensitization of A1 Adenosine Receptors
1995It is well known that exposure of sensitive cells to receptor agonists can cause a progressive reduction in their capacity to respond to this and related agonists. This phenomenon has been observed with cells expressing receptors from different superfamilies, and has been termed desensitization, refractoriness,tolerance, or tachyphylaxis [1].
Edmund Hoppe, Martin J. Lohse
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Adenosine receptors on human leukocytes IV. characterization of an A1/Ri receptor
International Journal of Clinical & Laboratory Research, 1992Adenosine (10(-9)-10(-6) mol/l) and R-phenylisopropyladenosine (10(-9)-10(-7) mol/l) partially inhibited the intracellular accumulation of cyclic AMP induced by isoproterenol, prostaglandin E1, histamine and 5'-N-ethylcarboxamidoadenosine in lymphocytes.
Gianni Marone +4 more
openaire +5 more sources
Journal of Molecular and Cellular Cardiology, 2001
Reactive oxygen species (ROS) formation following brief periods of ischemia or hypoxia is thought to be the underlying cause of myocardial stunning. Adenosine A1 receptor activation prior to ischemia/hypoxia attenuates stunning, although the mechanism ...
Prakash Narayan +2 more
semanticscholar +1 more source
Reactive oxygen species (ROS) formation following brief periods of ischemia or hypoxia is thought to be the underlying cause of myocardial stunning. Adenosine A1 receptor activation prior to ischemia/hypoxia attenuates stunning, although the mechanism ...
Prakash Narayan +2 more
semanticscholar +1 more source
Xanthine derivatives as antagonists at A1 and A2 adenosine receptors
Naunyn-Schmiedeberg's Archives of Pharmacology, 1985A variety of alkylxanthines has been comparatively examined as antagonists of A1 adenosine receptors in rat fat cells, rat and bovine cerebral cortex and of A2 adenosine receptors in human platelets. With few exceptions all xanthine derivatives with 7-position substituents such as diprophylline, proxyfylline, pentoxifylline and etofylline were less ...
Martin J. Lohse +2 more
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A novel irreversible antagonist of the A1-adenosine receptor.
Molecular Pharmacology, 1996We determined the effects of 8-cyclopentyl-3-[3-[[4-(fluorosulfonyl)benzoyl]oxy]propyl]-1-propylxanth ine (FSCPX), a putative irreversible antagonist of the A1-adenosine receptor, on cardiac A1-adenosine receptor-mediated responses and on the specific binding of [3H]-8-cyclopentyl-1,3-dipropylxanthine ([3H]CPX) to guinea pig cardiac and brain membranes.
M, Srinivas +5 more
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Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
Nature, 2018C. Draper-Joyce +15 more
semanticscholar +1 more source
Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-vornhagen +2 more
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