Results 111 to 120 of about 215,850 (301)

Antihyperglycemic, antihyperlipidemic, anti-inflammatory and adenosine deaminase– lowering effects of garlic in patients with type 2 diabetes mellitus with obesity

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2013
Introduction Type 2 diabetes mellitus is a chronic disorder characterized by chronic hyperglycemia, with long term macrovascular and microvascular complications. The treatment is lifestyle management, exercise, weight control, and antihyperglycemic drugs
Rahat Kumar, Simran Chhatwal, Sahiba Arora, Sitanshi Sharma, Jaswinder Singh, Narinder P. Singh, Vikram Bhandari, A. Khurana   +7 more
semanticscholar   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, EarlyView.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine*

Journal of Biological Chemistry, 2013
Background: Newborns have elevated plasma adenosine levels, which may influence their immunological function. Results: Compared with adults, newborns have elevated plasma 5′-NT and alkaline phosphatase activities and lower adenosine deaminase activity ...
M. Pettengill, S. Robson, Megan Tresenriter, J. Millán, A. Usheva, T. Bingham, M. Belderbos, Ilana Bergelson, S. Burl, B. Kampmann, Laura Gelinas, T. Kollmann, L. Bont, O. Levy   +13 more
semanticscholar   +1 more source

Making Advanced Therapies Affordable and Accessible: Two Strategic Approaches

Developing World Bioethics, EarlyView.
ABSTRACT This article explores two complementary strategies for addressing the affordability and access challenges facing advanced therapies. As high development costs and limited market access have led to the withdrawal of several therapies, the article examines how these barriers create ‘valleys of death’ that prevent innovation from reaching ...
Ubaka Ogbogu, Lauren Albrecht
wiley   +1 more source

Adenosine Deaminase in Diagnosis of Tuberculosis: A Review

, 2014
The diagnosis of tuberculosis (TB) continues to be a challenge in clinical practice. Traditional diagnostic methods are very useful but do not provide enough sensitivity and specificity.
R. Barua, Marufa Hossain
semanticscholar   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

The FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis

Mediators of Inflammation, 2014
Purinergic signalling is remarkably plastic during gastrointestinal inflammation. Thus, selective drugs targeting the “purinome” may be helpful for inflammatory gastrointestinal diseases. The myenteric neuromuscular transmission of healthy individuals is
Cátia Vieira, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, Isabel Silva, Ana Sofia Dias, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá   +7 more
doaj   +1 more source

Evaluation of the adenosine deaminase (ADA) G22A gene polymorphism with recurrent spontaneous abortion among Egyptian patients

Central European Journal of Immunology, 2017
Introduction : Adenosine and deoxyadenosine metabolism is influenced by adenosine deaminase (ADA) enzyme. ADA increases in different diseases and is considered as one of the markers for cell-mediated immunity.
Hanan Mohamed Farhan, Khadiga Abu-Gabal, Maha Katta, Raghda Ibrahim   +3 more
doaj   +1 more source

Role of Sulphydryl Groups in Adenosine Deaminase [PDF]

, 1967
G. Ronca, C. Bauer, Carlo Rossi
openalex   +1 more source

Development of cytosine and adenine base editors for maize precision breeding

Journal of Integrative Plant Biology, EarlyView.
A series of maize cytosine and adenine base editors was developed using various deaminase variants, enabling efficient multiplex genome editing in maize. Precise editing of the ZmACC1/2 genes generated herbicide‐tolerant maize germplasm, offering a solution for weed management in maize‐soybean intercropping systems.
Xiao Fu, Nan Wang, Lina Li, Dexin Qiao, Xiantao Qi, Changlin Liu, Zhaoxu Gao, Chuanxiao Xie, Jinjie Zhu   +8 more
wiley   +1 more source