Results 111 to 120 of about 238,585 (333)
Interpolated inverse discrete wavelet transforms in additive and non-additive spectral background correction [PDF]
arXiv, 2023 We demonstrate the applicability of using interpolated inverse discrete wavelet transforms as a general tool for modeling additive or multiplicative background or error signals in spectra. Additionally, we propose an unsupervised way of estimating the optimal wavelet basis along with the model parameters.
arxiv
Serum adenosine deaminase as oxidative stress marker in type 2 diabetes mellitus [PDF]
, 2017 Background: Oxidative stress markers are increased in type 2 diabetes mellitus and its estimation helps in predicting the long term complications.
., Sushith +3 more
core +1 more source
Computational Study of Molecular Mechanisms of Caffeine Actions [PDF]
arXiv, 2015 Caffeine (CAF) is one of the most widely and regularly consumed biologically active substances. We use computer simulation approach to the study of CAF activity by searching for its possible complexes with biopolymer fragments. The principal CAF target at physiologically important concentrations refers to adenosine receptors.
arxiv
A study on the inhibition of adenosine deaminase
Journal of Enzyme Inhibition and Medicinal Chemistry, 2008 Adenosine deaminase (ADA, EC 3.5.4.4) catalyses the irreversible deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine, respectively. In this study the inhibition of ADA from bovine spleen by several molecules with structure related to that of the substrate or product has been quantified. The inhibitors adenine, purine, inosine,
Sergio Alunni, Laura Ottavi, Mara Orrù
openaire +3 more sources
Secreted bacterial adenosine deaminase is an evolutionary precursor of adenosine deaminase growth factor [PDF]
Molecular Biology and Evolution, 2018 Adenosine deaminases (ADAs) play a pivotal role in regulating the level of adenosine, an important signaling molecule that controls a variety of cellular responses. Two distinct ADAs, ADA1 and adenosine deaminase growth factor (ADGF aka ADA2), are known.
Anton V. Zavialov +4 more
openaire +4 more sources
Cardiovascular Research, 2016 Aims Extracellular nucleotides and adenosine that are formed or degraded by membrane-bound ecto-enzymes could affect atherosclerosis by regulating the inflammation and thrombosis.
B. Kutryb-Zając +13 more
semanticscholar +1 more source
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source
Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]
, 2020 Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu +2 more
core +2 more sources
Protein molecular function prediction by Bayesian phylogenomics. [PDF]
PLoS Computational Biology, 2005 We present a statistical graphical model to infer specific molecular function for unannotated protein sequences using homology. Based on phylogenomic principles, SIFTER (Statistical Inference of Function Through Evolutionary Relationships) accurately ...
Barbara E Engelhardt +3 more
doaj +1 more source
Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer. [PDF]
, 1987 Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals.
Bordignon, C +9 more
core