Results 91 to 100 of about 54,805 (241)

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview

American Journal of Hematology, Volume 101, Issue S1, Page 56-74, April 2026.
ABSTRACT The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs.
Adetola A. Kassim, Alexis A. Thompson, Punam Malik   +2 more
wiley   +1 more source

Chemotherapy Effects on the Activities of Some Purine Metabolic Enzymes in Sera of Ovarian Cancer Patients

مجلة بغداد للعلوم, 2010
Adenosine deaminase (ADA; Ec: 3.5.4.4), 5´- Nucleotidase (5´– NT; Ec: 3.1.3.5), and AMP – amino hydrolase (AMP – deaminase AMPDA; Ec: 3.5.4.6) activities were measured in sera of ovarian cancer patients before surgery, and after chemotherapy.
Baghdad Science Journal
doaj   +1 more source

Diagnostic performance of salivary markers of Alzheimer's disease: A systematic review

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract High heterogeneity of diagnostic accuracy have been reported for salivary markers of Alzheimer's disease (AD), but the reasons remain unclear. This systematic review aims to evaluate the potential sources of heterogeneity in the diagnostic performance of salivary biomarkers for the identification of AD.
Priscilla Vendramini Borelli, Leonardo Machado, Giovanna Carello‐Collar, Pamela C. L. Ferreira, Amanda Muliterno Domingues Lourenço de Lima, Bruna Bellaver, Tharick Ali Pascoal, Andrea L. Benedet, Nicholas J. Ashton, Eduardo R Zimmer, Wyllians Vendramini Borelli   +10 more
wiley   +1 more source

SIGNIFICANCE OF ADENOSINE DEAMINASE SERUM CONCENTRATIONS IN THE DIAGNOSIS OF EXTRA-PULMONARY TUBERCULOSIS [PDF]

Journal of IMAB, 2011
Extra pulmonary tuberculosis (EPTB) is a growing problem worldwide. Due to the nature of the disease, the diversity of clinical pictures as well as its minor epidemiological importance, the diagnosis is difficult and often late.In addition to standard TB
Stevanovic G,, Pelemis M,, Pavlovic M,, Lavadinovic L,, Dakic Z,, Milosevic I,, Milosevic B.   +6 more
doaj  

Cerebellum Transcriptome of Mice Bred for High Voluntary Activity Offers Insights into Locomotor Control and Reward-Dependent Behaviors. [PDF]

, 2016
The role of the cerebellum in motivation and addictive behaviors is less understood than that in control and coordination of movements. High running can be a self-rewarding behavior exhibiting addictive properties.
Caetano-Anollés, Kelsey, Garland, Theodore, Hernandez, Alvaro G, Perez, Sam D, Rhodes, Justin S, Rodriguez-Zas, Sandra L, Southey, Bruce R   +6 more
core   +2 more sources

Aicardi‐Goutières Syndrome Type 6: Case Report and Structural Prediction Supporting a Dominant‐Negative Effect of the ADAR1 c.3019G>A Variant

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Aicardi–Goutières syndrome type 6 (AGS6) is a genetically determined autoinflammatory disorder, classically inherited in an autosomal recessive manner. We report a Czech child with a heterozygous ADAR1 NM_001111.5:c.3019G>A variant causing AGS6.
Katerina Turan, Petra Pokorna, Kamila Rihova, Jana Kubatova, Katerina Kozelkova, Eliska Hlouskova, Pavlina Danhofer, Petr Jabandziev, Jiri Damborsky, Regina Demlova, Ondrej Slaby, Katerina Slaba   +11 more
wiley   +1 more source

Potential Hypoglycemic, Hypolipidemic, and Hypouricemic Bioactive Components From Ampelopsis grossedentata Explored by Affinity Ultrafiltration With Three Enzyme Targets

eFood, Volume 7, Issue 2, April 2026.
By integrating bioaffinity ultrafiltration coupled with HPLC‐MS/MS, this study identified quercetin, myricetrin, dihydromyricetin, and taxifolin from Ampelopsis grossedentata as key inhibitors of α‐glucosidase, pancreatic lipase, and xanthine oxidase, highlighting the promising potential of A.
Siyang Mao, Chu Chu, Yanzhi Xiong, Mengjia Xu, Jian Yang, Mingquan Guo   +5 more
wiley   +1 more source

ADAR1 Controls Macrophage Scavenging and Lipid‐Buffering Programs in Metabolic Tissues

European Journal of Immunology, Volume 56, Issue 4, April 2026.
ADAR1 expression increase during monocyte‐to‐macrophage differentiation via an alternative transcription start site. Isoform‐specific ADAR1 activity governs key macrophage functions, including efferocytosis, endocytosis, lipid metabolism, and proliferation.
Achilleas Fardellas, Emelie Barreby, Madara Brice, Sebastian Nock, Jules Russick, Ana Vankova, Charlotte Edberg, Ida Robertsen, Jens K. Hertel, Per Stål, Gunnar Mellgren, Cecilia Karlsson, Jøran S. Hjelmesaeth, Hannes Hagström, Erik Näslund, Volker M. Lauschke, Johan Fernø, Ping Chen, Cecilia Morgantini, Myriam Aouadi, Niklas K. Björkström   +20 more
wiley   +1 more source

A new intrinsic thermal parameter for enzymes reveals true temperature optima [PDF]

, 2004
Two established thermal properties of enzymes are the Arrhenius activation energy and thermal stability. Arising from anomalies found in the variation of enzyme activity with temperature, a comparison has been made of experimental data for the activity ...
Daniel, Roy M., Danson, Michael J., Eisenthal, Robert, Peterson, Michelle E., Spence, Alastair   +4 more
core   +2 more sources

Natural Remedies for Gut Health: The Role of Plant Extracts in Combating Inflammatory Bowel Disease and Colon Cancer

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Created in BioRender. Haralambie, O. (2025) https://BioRender.com/dh5ly89. ABSTRACT Digestive disorders such as inflammatory bowel disease (IBD) and colorectal cancer are among the most significant global health challenges, largely driven by chronic inflammation and oxidative stress.
Oana‐Roxana Haralambie, Sanda Andrei
wiley   +1 more source