Results 111 to 120 of about 54,805 (241)

Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan, Ezgi Erbasan, Fulya Erendor, Salih Sanlioglu   +3 more
wiley   +1 more source

Diagnostic value of serum Adenosine deaminase and its isoenzymes in the diagnosis of pulmonary tuberculosis

مجله دانشگاه علوم پزشکی گرگان, 2008
Background & Objective: Adenosine deaminase is an enzyme which catalyses adenosine to Inosine. The determination of adenosine deaminase in body fluids is important for the diagnosis of tuberculosis.
Hamid Reza Joshaghani, Ezzat Ollah Ghaemi, Farhad Niknejad, Heydar Tavilani   +3 more
doaj  

Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis

Mediators of Inflammation, 2014
Purinergic signalling is remarkably plastic during gastrointestinal inflammation. Thus, selective drugs targeting the “purinome” may be helpful for inflammatory gastrointestinal diseases. The myenteric neuromuscular transmission of healthy individuals is
Cátia Vieira, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, Isabel Silva, Ana Sofia Dias, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá   +7 more
doaj   +1 more source

Cas9‐Embedding Hyperactive TadA8e Confers Efficient and Highly Specific A‐To‐G Base Editing in Rice

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2576-2591, April 2026.
ABSTRACT Adenine base editors (ABEs) produce precise A‐to‐G conversion in the genomic target sites without causing double‐strand breaks. However, the hyperactive adenosine deaminase TadA8e raises safety concerns on genome‐wide off‐target edits. We engineered 11 chimeric proteins for ABEs (CP‐ABEs) by embedding hyperactive TadA8e within Cas9 nickase to ...
Jianjian Hu, Xue Li, Yuhong Gao, Yifan Guo, Yini Liu, Chen Wang, Gencheng Xu, Chaoyue Du, Shijia Liu, Zhigang Zhao, Yihua Wang, Yufeng Wu, Xiaoou Dong, Chao Li, Jianmin Wan   +14 more
wiley   +1 more source

ADENOSINEDEAMINASE ACTIVITY IN CEREBROSPINAL FLUID FOR DIAGNOSIS OF TUBERCULOSIS MENINGITIS [PDF]

Background:Tuberculous meningitis remains a serious clinical problem. Missed diagnosis and delayed treatment result in significant morbidity and mortality.
Harish Bhat, Ramakrishna M R, Srinivas T, Srinivasa Rao K, Srinivasa Rao K, Trupti R R   +5 more
core  

Safety evaluation of the food enzyme AMP deaminase from the genetically modified Bacillus subtilis strain CCTCC M 2023264

EFSA Journal, Volume 24, Issue 4, April 2026.
Abstract The food enzyme AMP deaminase (AMP aminohydrolase; EC 3.5.4.6) is produced with the genetically modified Bacillus subtilis strain CCTCC M 2023264 by Angel Yeast Co., Ltd. The production strain of the food enzyme contains multiple copies of three acquired antimicrobial resistance genes, therefore it does not fulfil the requirements of the ...
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Magdalena Andryszkiewicz, Yi Liu   +14 more
wiley   +1 more source

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

Nature Communications, 2017
Adenosine deaminase acting on RNA 1 (ADAR1) edits adenosine to inosine. Here the authors, using parallel analysis of RNA secondary structure sequencing, provide evidence that ADAR1 induces sequence-context-dependent RNA secondary structures changes ...
Oz Solomon, Ayelet Di Segni, Karen Cesarkas, Hagit T. Porath, Victoria Marcu-Malina, Orel Mizrahi, Noam Stern-Ginossar, Nitzan Kol, Sarit Farage-Barhom, Efrat Glick-Saar, Yaniv Lerenthal, Erez Y. Levanon, Ninette Amariglio, Ron Unger, Itamar Goldstein, Eran Eyal, Gidi Rechavi   +16 more
doaj   +1 more source

Adenosine deaminase [PDF]

Biochemical Journal, 1942
openaire   +2 more sources

The ADA*2 Allele of the Adenosine Deaminase Gene and Recurrent Spontaneous Abortions in Northwest of Iran

Journal of Ardabil University of Medical Sciences, 2015
Background & objectives: Recurrent spontaneous abortion (RSA) is defined by two or more consecutive miscarriages before 20 weeks of gestation. Adenosine deaminase (ADA) is an enzyme of purine salvage pathway and has two important isoenzymes ADA1 and ADA2.
M Bonyadi, A Mohammadi, M Khalajkondori, S Taghavi   +3 more
doaj  

Tuberculosis Peritonitis Patient with Septic Shock Caused by Extended–Spectrum Beta Lactamases Producing Pseudomonas Aeruginosa [PDF]

, 2014
According to World Health Organization (WHO), tuberculosis (TB) is a worldwide pandemic. Up to 5% of patients with TB may have abdominal disease and 25-60% may have peritoneal involvement.
Bayupurnama, P. (Putut), Cahyono, S. B. (Suharjo), Nurdjanah, S. (Siti), Ratnasari, N. (Neneng), Triwikatmani, C. (Catharina)   +4 more
core