Results 71 to 80 of about 29,859 (206)

Neonatal Diamond‐Blackfan anemia with persistent neutropenia caused by an RPS15A variant

Pediatric Investigation, EarlyView.
Hong Zheng, Kaimei Wang, Jian Wang, Jianpei Fang, Dunhua Zhou, Kunyin Qiu   +5 more
wiley   +1 more source

Coupling of both a transactivation module and a double‐stranded DNA‐binding domain boosts Cas12i3 variant‐based cytosine and adenine editing in plants

Journal of Integrative Plant Biology, EarlyView.
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang, Jingying Li, Yucai Li, Lei Yan, Christina Seok Yien Yong, Shaoya Li, Yubing He, Lanqin Xia   +7 more
wiley   +1 more source

Adenosine deaminase type 2 deficiency: From rare to commonUpdate on human adenosine deaminase 2 deficiency [PDF]

Journal of Human Immunity
Wouters et al. review the clinical and genetic landscape of DADA2, a multisystem inborn error of immunity. It examines expanding phenotypes, emerging pathophysiological mechanisms, treatment strategies, and newly described dominant-negative variants that
Marjon Wouters, Verena Kienapfel, Lisa Ehlers, Hasan Hashem, Ivona Aksentijevich, Isabelle Meyts   +5 more
doaj   +1 more source

Optimized TadA‐derived base editors efficiently manipulate mRNA splicing by A‐to‐G and C‐to‐K editing in potato

Journal of Integrative Plant Biology, EarlyView.
Two optimized TadA‐derived base editors efficiently generate diverse splicing variants by targeting specific splice sites in potato. ABSTRACT Pre‐messenger RNA (pre‐mRNA) splicing is a critical mechanism for post‐transcriptional regulation in plants. Through alternative splicing, plants produce diverse transcriptomes and proteomes that finely regulate ...
Kaiyuan Chen, Yan Zhang, Jiuzhou Deng, Lumin Zhang, Huiying Zhou, Yaxin Duan, Enle Xiao, Guangtao Zhu, Chunzhi Zhang   +8 more
wiley   +1 more source

Evaluation of Serum Level of Adenosine Deaminase in Patients with Plaque Psoriasis before and after Topical Treatment [PDF]

پزشکی بالینی ابن سینا
Background and Objective: Adenosine deaminase is an enzyme that plays a role in the catabolism of purine bases, and uric acid is the final product of purine base metabolism. This study aimed to determine the serum level of adenosine deaminase in patients
Hamidreza Ghasemibasir, Elham khanlarzade, Rezvan Bakhtiari, Mohammad Jamshidi   +3 more
doaj  

Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC–MS/MS

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Joshua J. Deppas, Reyna Jones, Robert A. Parise, Pinakin Pandya, Christopher J. Bakkenist, Jan H. Beumer   +5 more
wiley   +1 more source

Adenosine Deaminase Activity in COPD Patients and Healthy Subjects

Iranian Journal of Allergy, Asthma and Immunology, 2010
Chronic obstructive pulmonary disease (COPD) has been defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD), as a disease state characterized by airflow limitation which is not fully reversible.
Mohammad Taghi Goodarzi, Mohammad Abdi, Heidar Tavilani, Ebrahim Nadi, Mojtaba Rashidi   +4 more
doaj  

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source

Serum adenosine deaminase activity is elevated in cutaneous leishmaniasis and decreases following treatment

Microbes, Infection and Chemotherapy
Introduction: Leishmaniases are infectious diseases caused by Leishmania protozoa, affecting millions worldwide. Diagnosis can be challenging. Accurate, non-invasive, and rapid diagnostic methods are needed.
Juan J. Milla Espino, Márcia Hueb, Rodrigo Haddad, Daiani C. Alves Haddad, Elza Ferreira Noronha   +4 more
doaj   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source