Results 71 to 80 of about 132,212 (243)
Neuroprotection, EarlyView.Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji +4 more
wiley +1 more source
Adenosine deaminase (ADAR) mRNA expression.
, 2013 No significantly increased expression of the adenosine deaminase, ADAR1 (A) or ADAR2 (B) in the hippocampus. No significantly increased expression of the hypothalamic adenosine deaminase, ADAR1 (C) or ADAR2 (D) in hypothalamus during the day.
Ian B. Jeffery (182963) +4 more
core +1 more source
A study on the inhibition of adenosine deaminase
Journal of Enzyme Inhibition and Medicinal Chemistry, 2008 Adenosine deaminase (ADA, EC 3.5.4.4) catalyses the irreversible deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine, respectively. In this study the inhibition of ADA from bovine spleen by several molecules with structure related to that of the substrate or product has been quantified. The inhibitors adenine, purine, inosine,
Sergio, Alunni +2 more
openaire +2 more sources
Development of adenosine signalling in the cerebellum [PDF]
The release and clearance of adenosine are reasonably well-documented in the mature CNS but relatively little is known about how adenosine signalling changes during postnatal development.
Atterbury, Alison
core
Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events
Phytotherapy Research, EarlyView.An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia +1 more
wiley +1 more source
A comparative study of adenosine deaminase in normal and cancerous human tissues
, 1972 The present work has endeavored to survey the occurence of adenosine deaminase as well as its multiple forms in normal and some cancerous human tissues.
Magers, Thomas A., 1943-
core
Clinical Significance of Serum Adenosine Deaminase Levels in Breast Cancer Patients
Journal of Islamic International Medical College, 2021 Objective: To compare serum adenosine deaminase (ADA) levels in untreated and treated cases of breast cancer patients. Study Design: It was an Analytical, observational study. Place and Duration of study: The study was carried out in the Department
Wajahat Ullah Khan, Amena Rahim, Kenza Mobeen, Muhammad Afzal, Abdul Khaliq Naveed
doaj
Rheumatology &Autoimmunity, EarlyView.This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues +6 more
wiley +1 more source
A adenosinadesaminase. Uma enzima pluridisciplinar.
Acta Médica Portuguesa, 1991 Adenosine deaminase is an enzyme that actively participates in the metabolism of the adenine nucleotides. It catalyzes the irreversible hydrolytic deamination of deoxyadenosine and adenosine with the production of deoxyinosine and inosine respectively ...
J G da Cunha
doaj +1 more source
Adenosine—A Regulator of Human Testicular Peritubular Cells
Andrology, EarlyView.ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz +12 more
wiley +1 more source