Results 81 to 90 of about 29,859 (206)
Cancer Medicine, Volume 15, Issue 8, August 2026.ABSTRACT Patient‐derived organoids (PDOs) have emerged as physiologically relevant cancer models that preserve key genetic, histological, and functional features of the tumors from which they are derived. In parallel, CRISPR‐based perturbation technologies have transformed functional genomics by enabling scalable interrogation of gene function.
Julianne du Plessis, Aadilah Omar
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Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Systemic lupus erythematosus (SLE) can closely mimic rheumatoid arthritis, leading to diagnostic delays. In patients with atypical inflammatory arthritis, early echocardiographic evaluation is vital to detect rare but life‐threatening complications like cardiac tamponade, ensuring prompt transition from RA‐directed therapy to life‐saving ...
Ayush Bakhrel +5 more
wiley +1 more source
مجله دانشگاه علوم پزشکی گرگان, 2008 Background & Objective: Adenosine deaminase is an enzyme which catalyses adenosine to Inosine. The determination of adenosine deaminase in body fluids is important for the diagnosis of tuberculosis.
Hamid Reza Joshaghani +3 more
doaj
The Dual Role of the Gut Microbiota in Cancer Chemoresistance
MicrobiologyOpen, Volume 15, Issue 4, August 2026.Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi +3 more
wiley +1 more source
De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence
MicrobiologyOpen, Volume 15, Issue 4, August 2026.Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi +2 more
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Nucleotide Metabolism in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao +7 more
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Recent Advances in the Molecular Mechanisms of Bacterial Anti‐Phage Defence Systems
Microbial Biotechnology, Volume 19, Issue 8, August 2026.Panoptes as an example for an antiphage system consists of OptS producing a cyclic dinucleotide that prevents activation of OptE, a transmembrane protein. Phage T4 infection introduces the sponge protein Acb2 that adsorbs the cyclic dinucleotide thus activating OptE which disrupts the cell membrane aborting phage infection.
Harald Brüssow
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TLS as Predictors and Targets in Neoadjuvant Chemoimmunotherapy for NSCLC
Thoracic Cancer, Volume 17, Issue 16, August 2026.TLS in lung cancer adjuvant therapy: (A) cellular composition (T/B cells, DCs); (B) mechanistic pathways (antigen presentation, GC‐like B responses, TRM maintenance); (C) clinical evaluation (IHC, digital pathology, spatial transcriptomics); (D) future directions (dynamic monitoring, intercellular interactions, multicenter trials, clinical translation).
Zhiqi Li +6 more
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British Journal of Pharmacology, Volume 183, Issue 16, Page 4761-4777, August 2026.Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin +10 more
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