Results 121 to 130 of about 215,850 (301)

Diagnostic value of serum Adenosine deaminase and its isoenzymes in the diagnosis of pulmonary tuberculosis

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2008
Background & Objective: Adenosine deaminase is an enzyme which catalyses adenosine to Inosine. The determination of adenosine deaminase in body fluids is important for the diagnosis of tuberculosis.
Hamid Reza Joshaghani   +3 more
doaj  

ADAR1 mRNA quantification for predicting HSIL in persons with HIV and abnormal anal cytology

open access: yesInternational Journal of Cancer, Volume 157, Issue 9, Page 1939-1947, 1 November 2025.
What's new? This study introduces ADAR1 mRNA quantification as a promising biomarker for improving high‐grade squamous intraepithelial lesion (HSIL) prediction in HIV‐positive individuals with abnormal anal cytology. With 92% specificity, it reduces unnecessary high‐resolution anoscopies (HRA) by 77%, offering a more efficient and targeted screening ...
Melissa Bello‐Perez   +15 more
wiley   +1 more source

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

open access: yesNature Communications, 2017
Adenosine deaminase acting on RNA 1 (ADAR1) edits adenosine to inosine. Here the authors, using parallel analysis of RNA secondary structure sequencing, provide evidence that ADAR1 induces sequence-context-dependent RNA secondary structures changes ...
Oz Solomon   +16 more
doaj   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

open access: yesAdvanced Science, Volume 12, Issue 33, September 4, 2025.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu   +7 more
wiley   +1 more source

Effect of Adenosine Deaminase upon the Antiviral Activity In Vitro of Adenine Arabinoside for Vaccinia Virus [PDF]

open access: green, 1974
James D. Connor   +4 more
openalex   +1 more source

Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2).

open access: yesJournal of Allergy and Clinical Immunology, 2020
Pui Y. Lee   +30 more
semanticscholar   +1 more source

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

open access: yesAdvanced Science, Volume 12, Issue 33, September 4, 2025.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng   +14 more
wiley   +1 more source

A Case of Refractory Nephrotic Syndrome Complicated With Tuberculous Pleurisy and Literature Review

open access: yesClinical Case Reports, Volume 13, Issue 9, September 2025.
ABSTRACT Nephrotic syndrome(NS) can be classified into steroid‐sensitive nephrotic syndrome (SSNS) and steroid‐resistant nephrotic syndrome (SRNS). Rifampicin is potentially leading to treatment resistance in NS. Here we report a case of SRNS secondary to rifampicin‐induced drug interactions during antituberculosis therapy.
Jiang‐min Wan   +5 more
wiley   +1 more source

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