Results 61 to 70 of about 215,850 (301)

Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma*

Journal of Biological Chemistry, 2017
RNA editing is a cellular process that precisely alters nucleotide sequences, thus regulating gene expression and generating protein diversity. Over 60% of human transcripts undergo adenosine to inosine RNA editing, and editing is required for normal ...
Eimile Oakes, A. Anderson, A. Cohen-Gadol, H. Hundley   +3 more
semanticscholar   +1 more source

Adenosine deaminase activity in leukaemia [PDF]

British Journal of Cancer, 1975
Adenosine deaminase (EC 3.5.4.4., ADA) has been measured in the blast cells of 36 patients with acute lymphoblastic, acute myeloid, chronic myeloid and chronic myeloid blast crisis leukaemia. Particularly high levels were found in acute lymphoblastic and chronic myeloid blast crisis patients.
J F Smyth, K R Harrap
openaire   +3 more sources

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

Hepatic ENTPD5 Is Critical for Maintaining Metabolic Homeostasis and Promoting Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
ENTPD5‐mediated conversion of extracellular adenosine triphosphate to ADP of hepatocytes is critical for maintaining hepatic glucose/lipid metabolism and promoting brown adipose tissue thermogenesis via the inhibition of adrenomedullin expression and secretion.
Rufeng Ma, Song Hou, Rui Xiang, Wenjun Liu, Xin Li, Yujing Chi, Ming Xu, Haochen Yao, Jing Li, Jichun Yang   +9 more
wiley   +1 more source

Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like Cells Aggressiveness

Cells, 2019
Glioblastoma is the brain tumor with the worst prognosis. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These cells produce high levels of extracellular adenosine, which are
Ignacio Niechi, Atenea Uribe-Ojeda, José Ignacio Erices, Ángelo Torres, Daniel Uribe, José Dellis Rocha, Pamela Silva, Hans G. Richter, Rody San Martín, Claudia Quezada   +9 more
doaj   +1 more source

Adenosine deaminase inhibition suppresses progression of 4T1 murine breast cancer by adenosine receptor‐dependent mechanisms

Journal of Cellular and Molecular Medicine, 2018
The activity of a cell‐surface ecto‐adenosine deaminase (eADA) is markedly increased in the endothelial activation and vascular inflammation leading to decreased adenosine concentration and alterations in adenosine signalling.
B. Kutryb-Zając, P. Koszałka, Paulina Mierzejewska, A. Bulinska, M. Zabielska, K. Brodzik, Aleksandra Skrzypkowska, Lukasz Zelazek, I. Pelikant-Małecka, E. Slominska, R. Smolenski   +10 more
semanticscholar   +1 more source

Urogenital Abnormalities in Adenosine Deaminase Deficiency [PDF]

Journal of Clinical Immunology, 2020
Abstract Background Improved survival in ADA-SCID patients is revealing new aspects of the systemic disorder. Although increasing numbers of reports describe the systemic manifestations of adenosine deaminase deficiency, currently there are no studies in the literature evaluating genital development and pubertal progress
Claire Booth, Silvia Pecorelli, Massimo Alfano, Andrea Salonia, Andrea Finocchi, Gigliola Di Matteo, Salvatore Recupero, Stuart Adams, Roberta Pajno, Caterina Cancrini, Silvia Ricci, Maria Pia Cicalese, Gianni Russo, Alessandro Aiuti, Federica Barzaghi, Francesca Ferrua, Arianna Lesma, Lucia Pacillo, Lucia Pacillo, Antonio Marzollo, Chiara Azzari   +20 more
openaire   +5 more sources

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
wiley   +1 more source

The Growing Spectrum of DADA2 Manifestations—Diagnostic and Therapeutic Challenges Revisited

Frontiers in Pediatrics, 2022
Deficiency of Adenosine Deaminase Type 2 (DADA2) is a rare autosomal recessive inherited disorder with a variable phenotype including generalized or cerebral vasculitis and bone marrow failure. It is caused by variations in the adenosine deaminase 2 gene
Carolin Escherich, Benedikt Bötticher, Stefani Harmsen, Marc Hömberg, Jörg Schaper, Myriam Ricarda Lorenz, Klaus Schwarz, Klaus Schwarz, Arndt Borkhardt, Prasad Thomas Oommen   +9 more
doaj   +1 more source

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

Advanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen, Xiangchao Xu, Jiahao Chen, Huiru Zhang, Wanshan Zheng, Wenzhe Yu, Xiaoqian Hu, Bin Cao   +7 more
wiley   +1 more source