Results 91 to 100 of about 90,132 (350)

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Equation-of-motion MLCCSD and CCSD-in-HF oscillator strengths and their application to core excitations [PDF]

arXiv, 2020
We present an implementation of equation-of-motion oscillator strengths for the multilevel CCSD (MLCCSD) model where CCS is used as the lower level method (CCS/CCSD). In this model, the double excitations of the cluster operator are restricted to an active orbital space, whereas the single excitations are unrestricted.
arxiv  

ASPIRIN RESISTANCE CANDIDATE GENES AND THEIR ASSOCIATION WITH THE RISK OF CARDIOVASCULAR EVENTS

Кардиоваскулярная терапия и профилактика, 2013
The review presents the current literature evidence on the most likely genetic polymorphisms of aspirin resistance, such as polymorphisms of cyclooxygenase, glycoproteins GP Ib/IIIa, GP Ibα, GP VI, and adenosine diphosphate receptors P2Y1 and P2Y12.
Yu. I. Grinshtein, A. A. Kosinova, I. Yu. Grinshtein   +2 more
doaj   +1 more source

P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]

, 2011
Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core   +1 more source

Platelet inhibitory effects of the Phase 3 anticancer and normal tissue cytoprotective agent, RRx-001. [PDF]

, 2018
The platelet inhibitory effects of the Phase 3 anticancer agent and nitric oxide (NO) donor, RRx-001, (1-bromoacetyl-3,3-dinitroazetidine) were examined ex vivo and compared with the diazeniumdiolate NO donor, diethylenetriamine NONOate (DETA-NONOate ...
Bryan Oronsky, Neil Oronsky, Pedro Cabrales, Santoro SA   +3 more
core   +1 more source

Kinetic Analysis of Protein Assembly on the Basis of the Center Manifold around the Critical Point [PDF]

arXiv, 2015
Protein assembly plays an important role in the regulation of biological systems. The cytoskeleton assembly activity is provided by the binding cofactors GTP (guanidine triphosphate) or ATP(adenosine triphosphate) to monomeric protein, and is initiated by assembling the monomeric proteins.
arxiv  

Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans [PDF]

, 2010
Background: The gene daf-2 encodes the single insulin/insulin growth factor-1-like receptor of Caenorhabditis elegans. The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan.
Braeckman, Bart, Brys, Kristel, Castelein, Natascha, Matthijssens, Filip, Vanfleteren, Jacques   +4 more
core   +3 more sources

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Energy from food [PDF]

arXiv, 2017
Expressing the energy content of food as the heat energy released by its combustion is potentially misleading. Food is used to produce adenosine triphosphate (ATP). The free energy of conversion of ATP into adenosine diphosphate is used directly for processes such as muscular contraction, without the need for intermediate heat production. The number of
arxiv  

A novel fluorescent probe for NAD-consuming enzymes [PDF]

, 2011
A novel, fluorescent NAD derivative is processed as substrate by three different NAD-consuming enzymes. The new probe has been used to monitor enzymatic activity in a continuous format by changes in fluorescence and, in one case, to directly visualize ...
Barrio, Belenky, Berger, Cakir-Kiefer, Capek, Collier, Gerd K. Wagner, Giulia Pergolizzi, Goulioukina, Graeff, Gruber, Guse, Jiang, Jiang, Julea N. Butt, Kahn, Kim, Lee, Legutko, Leonard, Lin, Moreau, Muller, Nottbohm, Oei, Pankiewicz, Pankiewicz, Pesnot, Pesnot, Pollak, Richard P. Bowater, Wall, Western, Wierzchowski, Wise, Zhang, Zhang, Ziegler   +37 more
core   +1 more source