Results 211 to 220 of about 102,475 (283)

Poly(adenosine diphosphate ribose) polymerase inhibition in isocitrate dehydrogenase 1 and 2-mutant tumors: Bridging science with the clinic. [PDF]

Cancer
Nassif Haddad E, Javle MM, Yap TA.
europepmc   +1 more source

Mitochondrial respiration and hydrogen peroxide production rate in right atrial tissues from obese diabetic patients

Experimental Physiology, Volume 111, Issue 4, Page 1643-1651, 1 April 2026.
Abstract Type 2 diabetes (T2D) is a global epidemic, with heart failure being the leading cause of premature death. Mitochondrial dysfunction, characterized by impaired energy metabolism, weakened energy transport system and increased oxidative stress, has been proposed as a key contributor to the impairment of contractile function in T2D hearts ...
Toan Pham, Sarbjot Kaur, Anthony Hickey, Marie‐Louise Ward, Kenneth Tran   +4 more
wiley   +1 more source

Epigenetic Modulation of the ACE System Underlies the Slow Aerobic Muscle Phenotype and Metabolic Exercise Response

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Weekly moderate‐to‐vigorous activity (≈6 h) induced a marked increase in ACE promoter methylation in exercised knee‐extensor muscle. In combination with the ACE I/D genotype, ACE methylation contributed to ACE gene activity regulation in ways aligning with the slow‐twitch, aerobic muscle phenotype and its metabolic response to endurance exercise ...
Flück Martin, Benedikt Gasser, Giraud Marie‐Noëlle   +2 more
wiley   +1 more source

The Adenosine Triphosphate-Adenosine Diphosphate Exchange Reaction of Oxidative Phosphorylation

Journal of Biological Chemistry, 1958
C L, WADKINS, A L, LEHNINGER
openaire   +2 more sources

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

International Journal of Cancer, Volume 158, Issue 6, Page 1617-1627, 15 March 2026.
What's new? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman, Niven Mehra, Laurien J. Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Addy C. M. van de Luijtgaarden, Theo van Voorthuizen, Tineke E. Buffart, Hans Gelderblom, Emile E. Voest, Henk M. W. Verheul   +15 more
wiley   +1 more source

Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models. [PDF]

Cancer, 2020
Santiago-O'Farrill JM, Weroha SJ, Hou X, Oberg AL, Heinzen EP, Maurer MJ, Pang L, Rask P, Amaravadi RK, Becker SE, Romero I, Rubio MJ, Matias-Guiu X, Santacana M, Llombart-Cussac A, Poveda A, Lu Z, Bast RC.   +17 more
europepmc   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Model for Predicting Serious Hematological Adverse Events in Individuals With Ovarian Cancer Receiving Poly (Adenosine Diphosphate Ribose) Polymerase Inhibitor Treatment: Prospective Cohort Study.

JMIR Med Inform
Lian X, Lei Y.
europepmc   +1 more source

Latin American Challenges and Recommendations for Poly Adenosine Diphosphate Ribose Polymerase Inhibitor Treatment in Metastatic Castration Resistant Prostate Cancer: An Expert Overview. [PDF]

Cancer Control
Borges Dos Reis R, Aguilar-Ponce JL, Cayol F, Jansen AM, K RM, Merino TR, Sanku G, Vaca LB, Isaacsson Velho P, Korbenfeld EP.   +9 more
europepmc   +1 more source

Differential sensitivity of various markers of platelet activation with adenosine diphosphate. [PDF]

Bionanoscience, 2019
Le Minh G, Peshkova AD, Andrianova IA, Weisel JW, Litvinov RI.   +4 more
europepmc   +1 more source