Results 71 to 80 of about 24,787 (206)

Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications [PDF]

, 2012
Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation ...
Jin, H, Yang, Z, Yu, P, Yue, J, Zhang, L, Zhang, L, Zhou, Y   +6 more
core   +2 more sources

Prostate cancer and PARP inhibitors: progress and challenges

Journal of Hematology & Oncology, 2021
Despite survival improvements achieved over the last two decades, prostate cancer remains lethal at the metastatic castration-resistant stage (mCRPC) and new therapeutic approaches are needed.
Diego Teyssonneau, Henri Margot, Mathilde Cabart, Mylène Anonnay, Paul Sargos, Nam-Son Vuong, Isabelle Soubeyran, Nicolas Sevenet, Guilhem Roubaud   +8 more
doaj   +1 more source

Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase. [PDF]

Journal of Clinical Investigation, 1987
The chromatin-bound enzyme poly(ADP-ribose) polymerase (ADPRP) is strongly stimulated by DNA with single- or double-stranded breaks, and transfers the ADP-ribose moiety of NAD to nuclear proteins. The activation of ADPRP is important for DNA repair and replication, and also has been postulated to play a role in the pathogenesis of lymphocyte ...
H, Yamanaka, E H, Willis, C A, Penning, C L, Peebles, E M, Tan, D A, Carson   +5 more
openaire   +2 more sources

Identification of a dihydropyridine scaffold that blocks ryanodine receptors

iScience, 2022
Summary: Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca2+ release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in skeletal muscle, heart, and brain has been implicated in various muscle pathologies ...
Gihan S. Gunaratne, Robyn T. Rebbeck, Lindsey M. McGurran, Yasheng Yan, Thiago Arzua, Talia Frolkis, Daniel J. Sprague, Xiaowen Bai, Razvan L. Cornea, Timothy F. Walseth, Jonathan S. Marchant   +10 more
doaj   +1 more source

Natural occurence of a biopolymer, poly (adenosine diphosphate ribose)

Nucleic Acids Research, 1977
Evidence for the natural occurrence of poly(adenosine diphosphate ribose) in vivo was obtained using a sensitive radioimmunoassay and poly(adenosine diphosphate ribose) glycohydrolase, which specifically hydrolyzes poly(adenosine diphosphate ribose).
H, Sakura, M, Miwa, M, Tanaka, Y, Kanai, T, Shimada, T, Matsushima, T, Sugimura   +6 more
openaire   +3 more sources

Demonstration of high molecular weight poly (adenosine diphosphate ribose)

Nucleic Acids Research, 1978
An electrophoretic system was established that resolves poly(adenosine diphosphate ribose), enzymatically synthesized polymer from NAD+, by size difference of one residue on polyacrylamide gel. The existence of a polymer of at least 65 residues was demonstrated by band counting in this system. The polymer showed a heterogeneous size distribution on the
M, Tanaka, K, Hayashi, H, Sakura, M, Miwa, T, Matsushima, T, Sugimura   +5 more
openaire   +3 more sources

Salvage enzymes in nucleotide biosynthesis [PDF]

, 2007
Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core  

Cordycepin enhances cisplatin apoptotic effect through caspase/MAPK pathways in human head and neck tumor cells [PDF]

, 2013
published_or_final_versio
Chen, YH, Huang, BM, Lai, MS, Mu, YF, Pan, BS, So, EC, Wang, JY, Wong, STS   +7 more
core   +1 more source

DNA repair and synthetic lethality [PDF]

, 2011
Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR ...
Delsite, Robert, Feng, Zhi-hui, Gao, Rui-jie, Guo, Gong-she, Powell, Simon N, Zhang, Feng-mei   +5 more
core   +2 more sources

Controversies and clinical unknowns in the use of PARP inhibitors in ovarian cancer

Therapeutic Advances in Medical Oncology
Poly (adenosine diphosphate-ribose) polymerase inhibitors (PARPi) have significantly improved the treatment of advanced ovarian cancer, however, there are still many aspects of their use that require further understanding.
Uma A. Mukherjee, Rowan E. Miller, Jonathan A. Ledermann   +2 more
doaj   +1 more source