Results 81 to 90 of about 13,187 (171)

Neoadjuvant fuzuloparib combined with abiraterone for localized high-risk prostate cancer (FAST-PC): A single-arm phase 2 study

Cell Reports Medicine
Summary: Preclinical studies suggest synergistic effects between androgen receptor inhibitors and poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors.
Tingwei Zhang, Beihe Wang, Yu Wei, Hualei Gan, Bangwei Fang, Xiaomeng Li, Junlong Wu, Xiaojie Bian, Jianfei Wang, Stephen J. Freedland, Shenglin Huang, Dingwei Ye, Yao Zhu   +12 more
doaj   +1 more source

Accumulation of poly (adenosine diphosphate-ribose) by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells. [PDF]

World J Gastroenterol, 2022
Jeong KY, Sim JJ, Park M, Kim HM.
europepmc   +1 more source

Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted ¹⁸F-Fluorthanatrace PET Images of Ovarian Cancer. [PDF]

J Nucl Med, 2022
Young AJ, Pantel AR, Viswanath V, Dominguez TL, Makvandi M, Lee H, Li S, Schubert EK, Pryma DA, Farwell MD, Mach RH, Simpkins F, Lin LL, Mankoff DA, Doot RK.   +14 more
europepmc   +1 more source

Patient cost sharing during poly(adenosine diphosphate-ribose) polymerase inhibitor treatment in ovarian cancer. [PDF]

Am J Obstet Gynecol, 2021
Harrison RF, Fu S, Sun CC, Zhao H, Lu KH, Giordano SH, Meyer LA.   +6 more
europepmc   +1 more source

Studies on Poly (Adenosine Diphosphate Ribose)

Journal of Biological Chemistry, 1970
Hirotaka Matsubara, Shuji Hasegawa, Shinji Fujimura, Teruo Shima, Takashi Sugimura, Masamitsu Futai   +5 more
openaire   +1 more source

Complete response to olaparib in a patient with metastatic pancreatic cancer harboring a germline BRCA2 mutation

Oncology in Clinical Practice
Metastatic pancreatic cancer (mPC) is usually diagnosed at an advanced stage, and systemic therapy is still the main treatment option. Pathological germline mutations in the BRCA1 or BRCA2 genes are present in aroun 4–7% of cases of pancreatic cancer (PC)
Agata I. Adamczuk-Nurzyńska, Paweł Nurzyński, Artur Sankowski   +2 more
doaj   +1 more source

Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications

Neural Regeneration Research
For diverse neurodegenerative disorders, microglial cells are activated. Furthermore, dysfunctional and hyperactivated microglia initiate mitochondrial autophagy, oxidative stress, and pathological protein accumulation, ending with neuroinflammation that
Wenhui Zhao, Zhongxuan Liu, Jiannan Wu, Anran Liu, Junqiang Yan   +4 more
doaj   +1 more source

Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium

Science Bulletin
Abstract Ion channel activation upon ligand gating triggers a myriad of biological events and, therefore, evolution of ligand gating mechanism is of fundamental importance. TRPM2, a typical ancient ion channel, is activated by adenosine diphosphate ribose ...
Cheng Ma, Yanping Luo, Congyi Zhang, Cheng Cheng, Ning Hua, Xiaocao Liu, Jianan Wu, Luying Qin, Peilin Yu, Jianhong Luo, Fan Yang, Lin-Hua Jiang, Guojie Zhang, Wei Yang   +13 more
openaire   +2 more sources

Studies on the Polymer of Adenosine Diphosphate Ribose

Journal of Biological Chemistry, 1967
Yasutomi Nishizuka, Kunihiro Ueda, Kinya Nakazawa, Osamu Hayaishi   +3 more
openaire   +2 more sources

Occurrence of Pancytopenia Among Patients With Cancer Treated With Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibitors: A Pharmacoepidemiologic Study.

JAMA Oncol, 2021
Morice PM, Chrétien B, Da Silva A, Dolladille C, Alexandre J.   +4 more
europepmc   +1 more source