Results 101 to 110 of about 34,973 (226)

GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV‑2 and Other Viral Macrodomains

Viral macrodomains that can bind to or hydrolyze protein adenosine diphosphate ribosylation (ADP-ribosylation) have emerged as promising targets for antiviral drug development.
Saket R. Bagde (5884562), Shamar D. Wallace (15384290), J. Christopher Fromme (2693497), Kewen Peng (8194929), Ananya Anmangandla (2571085), Jialin Shang (18421258), Hening Lin (1306563), Sadhan Jana (15348650)   +7 more
core   +1 more source

Bovine thymus poly(adenosine diphosphate ribose) polymerase. Physical properties and binding to DNA.

Journal of Biological Chemistry, 1980
Purified bovine thymus poly(adenosine diphosphate ribose) polymerase is a monomeric protein with a single polypeptide chain having a molecular weight of approximately 130,000, determined by sodium dodecyl sulfate-gel electrophoresis, analytical ...
H. Ohgushi, K. Yoshihara, T. Kamiya
semanticscholar   +1 more source

Roles for adenosine ribose hydroxyl groups in cyclic adenosine 5'- diphosphate ribose-mediated Ca²⁺ release

, 1997
Cyclic adenosine diphosphate ribose (cADPR) is a naturally occurring and potent Ca2+-mobilizing agent. Structural analogues are currently required as pharmacological tools for the investigation of this topical molecule, but modifications to date have ...
Ashamu, Gloria A., Potter, Barry V.L., Sethi, Jaswinder K., Galione, Antony   +3 more
core   +1 more source

Positive Chemotactic Flasklike Colloidal Motors Propelled by Rotary FoF1-ATP Synthases

Research
Living microorganisms can perform directed migration for foraging in response to a chemoattractant gradient. We report a biomimetic strategy that rotary FoF1-ATPase (adenosine triphosphatase)-propelled flasklike colloidal motors exhibit positive ...
Yue Li, Yingjie Wu, Qiang He
doaj   +1 more source

Progress in targeted therapy for breast cancer

Chronic Diseases and Translational Medicine, 2018
Breast cancer is a multistep, multifactorial, and heterogeneous disease. Significant transformations have occurred in the systemic management of breast cancer in the past decade.
Jie Ju, An-Jie Zhu, Peng Yuan
doaj   +1 more source

Unlocking Therapeutic Potential of Poly(Adenosine Diphosphate Ribose) Polymerase (PARP) Inhibitors in Metastatic Breast Cancer With BRCA Gene Mutations: A Narrative Review. [PDF]

Cureus, 2023
Jain P.
europepmc   +1 more source

Isopolar Phosphonate Analogue of Adenosine Diphosphate Ribose

, 2016
The synthesis of the bisphosphonate ADP-ribose, in which acetylene has replaced the oxygen of the pyrophosphate linkage, is ...
Marie E. Migaud (2426311), Kim Van derpoorten (2707048)   +1 more
core   +1 more source

Effects of DTX3L on the cell proliferation, adhesion, and drug resistance of multiple myeloma cells

Tumor Biology, 2017
Cell adhesion–mediated drug resistance is an important factor that influences the effects of chemotherapy in multiple myeloma. DTX3L, a ubiquitin ligase, plays a key role in cell-cycle-related process.
Yaodong Shen, Yuxiang Sun, Linlin Zhang, Hong Liu   +3 more
doaj   +1 more source

Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells

Blood Advances, 2018
: CD38 is a transmembrane exoenzyme that is associated with poor prognosis in chronic lymphocytic leukemia (CLL). High CD38 levels in CLL cells are linked to increased cell migration, but the molecular basis is unknown.
Silvia Mele, Stephen Devereux, Andrea G. Pepper, Elvira Infante, Anne J. Ridley   +4 more
doaj   +1 more source

Do Not Forget Poly (Adenosine Diphosphate-Ribose) Polymerase Inhibitors in Ovarian Carcinosarcoma. [PDF]

Cureus, 2022
Magalhães D, Bartosch C, Abreu MH.
europepmc   +1 more source