Electron Paramagnetic Resonance and Electron Spin Echo Studies of Co2+ Coordination by Nicotinamide Adenine Dinucleotide (NAD+) in Water Solution [PDF]
, 2013 Co(2+) binding to the nicotinamide adenine dinucleotide (NAD(+)) molecule in water solution was studied by electron paramagnetic resonance (EPR) and electron spin echo at low temperatures. Cobalt is coordinated by NAD(+) when the metal is in excess only,
Janina Goslar +2 more
core +1 more source
Concentration and synthesis of phosphoribosylpyrophosphate in erythrocytes from normal, hyperuricemic, and gouty subjects. [PDF]
, 1971 Phosphoribosylpyrophosphate (PRPP) synthetase activity and the intracellular concentration of PRPP were assayed in erythrocytes from patients with primary hyperuricemia and primary metabolic gout.
Meyskens, FL, Williams, HE
core
Drug-like antagonists of P2Y receptors — from lead identification to drug development [PDF]
, 2016 P2Y receptors are expressed in virtually all cells and tissue types and mediate an astonishing array of biological functions, including platelet aggregation, smooth muscle cell proliferation, and immune regulation.
Conroy, Sean +3 more
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Positive Chemotactic Flasklike Colloidal Motors Propelled by Rotary FoF1-ATP Synthases
ResearchLiving microorganisms can perform directed migration for foraging in response to a chemoattractant gradient. We report a biomimetic strategy that rotary FoF1-ATPase (adenosine triphosphatase)-propelled flasklike colloidal motors exhibit positive ...
Yue Li, Yingjie Wu, Qiang He
doaj +1 more source
Progress in targeted therapy for breast cancer
Chronic Diseases and Translational Medicine, 2018 Breast cancer is a multistep, multifactorial, and heterogeneous disease. Significant transformations have occurred in the systemic management of breast cancer in the past decade.
Jie Ju, An-Jie Zhu, Peng Yuan
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Unlocking Therapeutic Potential of Poly(Adenosine Diphosphate Ribose) Polymerase (PARP) Inhibitors in Metastatic Breast Cancer With BRCA Gene Mutations: A Narrative Review. [PDF]
Cureus, 2023 Jain P.
europepmc +1 more source
Effects of DTX3L on the cell proliferation, adhesion, and drug resistance of multiple myeloma cells
Tumor Biology, 2017 Cell adhesion–mediated drug resistance is an important factor that influences the effects of chemotherapy in multiple myeloma. DTX3L, a ubiquitin ligase, plays a key role in cell-cycle-related process.
Yaodong Shen +3 more
doaj +1 more source
Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells
Blood Advances, 2018 : CD38 is a transmembrane exoenzyme that is associated with poor prognosis in chronic lymphocytic leukemia (CLL). High CD38 levels in CLL cells are linked to increased cell migration, but the molecular basis is unknown.
Silvia Mele +4 more
doaj +1 more source
Do Not Forget Poly (Adenosine Diphosphate-Ribose) Polymerase Inhibitors in Ovarian Carcinosarcoma. [PDF]
Cureus, 2022 Magalhães D, Bartosch C, Abreu MH.
europepmc +1 more source
Programmed death ligand 1, poly adenosine diphosphate ribose polymerase, and vascular endothelial growth factor receptor inhibition: a potential combination regimen for targeting triple-negative breast cancer? [PDF]
Int J Surg, 2023 Abdul Wahid M +5 more
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