Results 111 to 120 of about 34,973 (226)

The status of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in ovarian cancer, part 1: olaparib [PDF]

, 2016
Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors have shown promising clinical activity in epithelial ovarian cancer. Following the observation in vitro that PARP inhibition is synthetically lethal in tumors with BRCA mutations, PARP ...
Miller, RE, Ledermann, JA
core  

Synthesis of ribosyl-ribosyl-adenosine-5 ',5 '',5'''(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose)

, 2017
Poly-adenosine diphosphate ribose (PAR) is a branched biopolymer that occurs as a result of post-translational modification of proteins. In 1981 Miwa et al. determined the structure of enzymatically prepared branched PAR.
Filippov, D.V., Overkleeft, H.S., Liu, Q., Kistemaker, H.A.V., Qiang Liu, Hans. A. V. Kistemaker, Herman S. Overkleeft, Dmitri V. Filippov, Marel, G.A. van der, Gijsbert A. van der Marel   +9 more
core   +1 more source

Programmed death ligand 1, poly adenosine diphosphate ribose polymerase, and vascular endothelial growth factor receptor inhibition: a potential combination regimen for targeting triple-negative breast cancer? [PDF]

Int J Surg, 2023
Abdul Wahid M, Hussain HU, Ghouri H, Khan T, Rehan ST, Mumtaz H.   +5 more
europepmc   +1 more source

Design, Synthesis, and Identification of 4″α-Azidoethyl-cyclic ADP-Carbocyclic-ribose as a Highly Potent Analogue of Cyclic ADP-Ribose, a Ca²⁺-Mobilizing Second Messenger

, 2016
Cyclic adenosine diphosphate-carbocyclic-ribose (cADPcR, 2) is a stable equivalent of cyclic adenosine diphosphate-ribose (cADPR, 1), a Ca2+-mobilizing second messenger.
Takatoshi Sato (1810768), Hayato Fukuda (754042), Satoshi Takano (1574866), Tomoshi Kameda (1368384), Mizuki Watanabe (1874182), Mitsuhiro Arisawa (754043), Satoshi Shuto (102368), Takashi Murayama (171791), Takayoshi Tsuzuki (1574869), Takashi Sakurai (171849)   +9 more
core   +1 more source

Poly Adenosine Diphosphate-Ribose Polymerase (PARP) Inhibitors in Pancreatic Cancer. [PDF]

Cureus, 2022
Sunkara T, Bandaru SS, Boyilla R, Kunadharaju R, Kukkadapu P, Chennamadhavuni A.   +5 more
europepmc   +1 more source

Accumulation of poly (adenosine diphosphate-ribose) by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells. [PDF]

World J Gastroenterol, 2022
Jeong KY, Sim JJ, Park M, Kim HM.
europepmc   +1 more source

The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5′-diphosphate-ribose) polymerase-1

, 2009
Granzyme A (GzmA) in killer cells induces caspase-independent programmed cell death. In this study, we show that GzmA cleaves the DNA damage sensor poly(adenosine 5'-diphosphate-ribose) polymerase-1 (PARP-1) after Lys(498) in its automodification domain,
Schlesinger, Ann, Martinvalet, Denis, Zhang, Dong, Chowdhury, Dipanjan, Lieberman, Judy, Zhu, Pengcheng   +5 more
core   +1 more source

Neoadjuvant fuzuloparib combined with abiraterone for localized high-risk prostate cancer (FAST-PC): A single-arm phase 2 study

Cell Reports Medicine
Summary: Preclinical studies suggest synergistic effects between androgen receptor inhibitors and poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors.
Tingwei Zhang, Beihe Wang, Yu Wei, Hualei Gan, Bangwei Fang, Xiaomeng Li, Junlong Wu, Xiaojie Bian, Jianfei Wang, Stephen J. Freedland, Shenglin Huang, Dingwei Ye, Yao Zhu   +12 more
doaj   +1 more source

Use of two-dimensional thin-layer chromatography for the components study of poly(adenosine diphosphate ribose)

, 1990
Two-dimensional thin-layer chromatography on cellulose plates has been used for separating and quantifying the three adenosine derivatives: AMP, phosphoribosyl AMP (PRAMP), and (PR)2AMP obtained by venom phosphodiesterase digestion of poly(ADP-ribose ...
Desgrès, J, Keith, G, Murcia, G,
core   +1 more source

Activation of the peroxynitrite-poly(adenosine diphosphate-ribose) polymerase pathway during neointima proliferation: A new target to prevent restenosis after endarterectomy

, 2006
ObjectiveIn a rat model of endarterectomy, we investigated the potential role of the peroxynitrite-poly(adenosine diphosphate[ADP]-ribose) polymerase (PARP) pathway in neointima formation and the effect of pharmacologic inhibition of PARP on vascular ...
Radovits, Tamás, Gerö, Domokos, Beller, Carsten J., Kosse, Jens, Szabó, Gábor, Szabó, Csaba   +5 more
core   +1 more source