Results 121 to 130 of about 34,973 (226)

Tumor treating fields combined with a poly (adenosine diphosphate-ribose) polymerase inhibitor during radiotherapy for rapidly progressing IDH-wildtype diffuse astrocytoma: a case report. [PDF]

J Int Med Res, 2021
Wang Z, Ren Y, Du F, Sun Y, Jiang W.
europepmc   +1 more source

Variable-Temperature NMR Spectroscopy, Conformational Analysis, and Thermodynamic Parameters of Cyclic Adenosine 5′-Diphosphate Ribose Agonists and Antagonists

, 2018
Cyclic adenosine 5′-diphosphate ribose (cADPR) is a ubiquitous Ca2+-releasing second messenger. Knowledge of its conformational landscape is an essential tool for unraveling the structure–activity relationship (SAR) in cADPR.
Steven M. Graham (2726578), Sarah-Marie Saatori (4857676), Tanner J. Perez (4857679)   +2 more
core   +1 more source

Novel treatment strategies in triple-negative breast cancer: specific role of poly(adenosine diphosphate-ribose) polymerase inhibition

Pharmacogenomics and Personalized Medicine, 2014
M William Audeh Division of Medical Oncology, Samuel Oschin Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA Abstract: Inhibitors of the poly(adenosine triphosphate-ribose) polymerase (PARP)-1 enzyme induce synthetic lethality in ...
Audeh MW
doaj  

Patient cost sharing during poly(adenosine diphosphate-ribose) polymerase inhibitor treatment in ovarian cancer. [PDF]

Am J Obstet Gynecol, 2021
Harrison RF, Fu S, Sun CC, Zhao H, Lu KH, Giordano SH, Meyer LA.   +6 more
europepmc   +1 more source

Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications

Neural Regeneration Research
For diverse neurodegenerative disorders, microglial cells are activated. Furthermore, dysfunctional and hyperactivated microglia initiate mitochondrial autophagy, oxidative stress, and pathological protein accumulation, ending with neuroinflammation that
Wenhui Zhao, Zhongxuan Liu, Jiannan Wu, Anran Liu, Junqiang Yan   +4 more
doaj   +1 more source

Studies on Poly (Adenosine Diphosphate Ribose)

Journal of Biological Chemistry, 1970
Hirotaka Matsubara, Shuji Hasegawa, Shinji Fujimura, Teruo Shima, Takashi Sugimura, Masamitsu Futai   +5 more
openaire   +1 more source

Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium

Science Bulletin
Abstract Ion channel activation upon ligand gating triggers a myriad of biological events and, therefore, evolution of ligand gating mechanism is of fundamental importance. TRPM2, a typical ancient ion channel, is activated by adenosine diphosphate ribose ...
Cheng Ma, Yanping Luo, Congyi Zhang, Cheng Cheng, Ning Hua, Xiaocao Liu, Jianan Wu, Luying Qin, Peilin Yu, Jianhong Luo, Fan Yang, Lin-Hua Jiang, Guojie Zhang, Wei Yang   +13 more
openaire   +2 more sources

Branching of poly(ADP-ribose): Synthesis of the Core Motif

, 2015
The synthesis of the core motif of branched poly­(adenosine diphosphate ribose) (poly­(ADPr)) is described, and structural analysis reasserted the proposed stereochemistry for branching.
Filippov, D.V., Overkleeft, H.S., Hans A. V. Kistemaker (1538152), Kistemaker, H.A.V., Herman S. Overkleeft (128584), Dmitri V. Filippov (364839), Gijsbert A. van der Marel (1537651), Marel, G.A. van der   +7 more
core   +1 more source

Diabetes increases apoptosis and necrosis in both ischemic and nonischemic human myocardium: Role of caspases and poly–adenosine diphosphate–ribose polymerase

, 2007
ObjectivesDiabetes is an important predictor of morbidity and mortality after cardiac surgery, but the reason is unclear. The aims of these studies, therefore, were to elucidate whether cell death is greater in ischemic and nonischemic diabetic human ...
Galiñanes, Manuel, Vohra, Hunaid A., Chowdhry, Mohammed F.   +2 more
core   +1 more source

Cyclic ADP ribose as a calcium-mobilizing messenger.

, 2000
This Perspective by Galione and Churchill is one in a series on intracellular calcium release mechanisms. The authors review the evidence for cyclic adenosine diphosphate ribose (cADPR) being a second messenger involved in regulating intracellular ...
Churchill, GC, Churchill, Grant, Galione, A, Galione, Antony   +3 more
core   +1 more source