Results 91 to 100 of about 24,988 (216)

Multi‐Omics Profiling Uncovers Predictive Factors for Tumor‐Infiltrating Lymphocyte Therapy in Ovarian Cancer

Journal of Clinical Laboratory Analysis, Volume 40, Issue 8, April 2026.
We profiled tumors from 10 ovarian cancer patients with whole‐exome sequencing (WES), bulk RNA‐seq, and single‐cell RNA‐seq to uncover predictors of successful tumor‐infiltrating lymphocyte (TIL) isolation and expansion. TIL+ tumors exhibited enriched CD8+ Teff/Tem populations with distinctive metabolic activity, dendritic‐cell–skewed myeloid states ...
Xiuzhen Wang, Rui Hou, Jinguo Chen, Bo He, Peiwen Liu, Genhai Zhu, Lan Hong, Wenjun Zhu   +7 more
wiley   +1 more source

Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals [PDF]

, 2016
Raw data for Fig. S2.
Alberto Puliafito, Andrea Bertotti, Barbara Lupo, Emanuela Pupo, Francesco Sassi, Jorge Vialard, Letizia Lanzetti, Livio Trusolino, Paolo M. Comoglio, Patrick Angibaud   +9 more
core   +16 more sources

Enzymic Adenosine Diphosphate Ribosylation of Histone and Poly Adenosine Diphosphate Ribose Synthesis in Rat Liver Nuclei

Journal of Biological Chemistry, 1968
An enzyme associated with mammalian chromatin catalyzed the transfer of the adenosine diphosphate ribose moiety of nicotinamide adenine dinucleotide to histone with the simultaneous release of nicotinamide. A successive transfer of the ADP-ribose moiety resulted in the formation and elongation of a homopolymer with repeating ADP-ribose units ...
Y, Nishizuka, K, Ueda, T, Honjo, O, Hayaishi   +3 more
openaire   +2 more sources

Quinolone tolerance in Escherichia coli due to defects in the adenosine ribonucleotides de novo biosynthesis pathway

mLife, Volume 5, Issue 2, Page 217-228, April 2026.
Abstract Central carbon metabolism is thought to link reactive oxygen species (ROS) with antibiotic‐mediated bacterial death. During enrichment screening of Escherichia coli with the first‐generation quinolone oxolinic acid, unstable antibiotic‐tolerant mutants containing deficiencies in purB were obtained.
Weiwei Zhu, Yuejuan Nong, Jie Su, Jingwen Yang, Lina Ma, Yunxin Xue, Dai Wang, Jianjun Niu, Karl Drlica, Xilin Zhao   +9 more
wiley   +1 more source

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities [PDF]

, 2013
Poly-ADP-ribosylation is a post-translational modification that regulates processes involved in genome stability. Breakdown of the poly(ADP-ribose) (PAR) polymer is catalysed by poly(ADP-ribose) glycohydrolase (PARG), whose endo-glycohydrolase activity ...
Ahel, Ivan, Ahel, Marijan, Banos, Benito, Barkauskaite, Eva, Brassington, Amy, Dunstan, Mark S., Lafite, Pierre, Leys, David, Mitchison, Timothy J., Tan, Edwin S., Warwicker, Jim   +10 more
core   +2 more sources

Differential Expression of NUDT9 at Different Phases of The Menstrual Cycle and in Different Components of Normal and Neoplastic Human Endometrium

Taiwanese Journal of Obstetrics & Gynecology, 2009
Objective: The human endometrium manifests different and distinct morphologies and physiologies during the different phases of the menstrual cycle.
Ling-Yun Chen, Tze-Ho Chen, Pao-Ying Wen, Chia-Hung Chou, Tsung-Ho Ying, Shun-Ping Chang, Gwo-Chin Ma, Ming Chen   +7 more
doaj   +1 more source

Double‐Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration

Aging Cell, Volume 25, Issue 4, April 2026.
A novel drug combination (NMN + API) promotes musculoskeletal regeneration in aging. By boosting NAD+, it activates SIRT3 to suppress cellular senescence and enhance differentiation into chondrocytes, osteoblasts, and myocytes. Oral administration reshapes the gut microbiota, increasing production of the anti‐aging metabolite PHS.
Jianfeng Yu, Mingzhuang Hou, Yaoge Deng, Chenqi Yu, Yang Liu, Kang Kang, Xiaowei Xia, Xiaoping Li, Huilin Yang, Dinghua Jiang, Wu Xu, Yijian Zhang, Xuesong Zhu   +12 more
wiley   +1 more source

First-line treatment of advanced ovarian cancer: an expert update

Libri Oncologici, 2020
Ovarian cancer is the fifth most common cause of death among malignant diseases in women in Europe. The standard treatment is cytoreductive surgery, followed by platinum-taxane based chemotherapy.
Branka Petrić-Miše
doaj   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Hyperglycemia induces apoptosis of pancreatic islet endothelial cells via reactive nitrogen species-mediated Jun N-terminal kinase activation [PDF]

, 2011
Hyperglycemia significantly stimulates pancreatic islet endothelial cell apoptosis; however, the precise mechanisms are not fully understood. In the present study, treating pancreatic islet endothelial (MS-1) cells with high glucose (30mmol/l) but not ...
Gong, Lei, Liu, Fu-qiang, Wang, Juan, Wang, Xu-ping, Hou, Xin-guo, Sun, Yu, Qin, Wei-dong, Wei, Shu-jian, Zhang, Yun, Chen, Li, Zhang, Ming-Xiang   +10 more
core   +1 more source