Results 91 to 100 of about 34,973 (226)

Synthesis of 7-deaza-8-bromo cyclic adenosine 5′-diphosphate ribose: The first hydrolysis resistant antagonist at the cADPR receptor

, 1997
7-Deaza-8-bromo cyclic adenosine 5′-diphosphate ribose is synthesised from 7-deazaadenosine via 7-deaza-8-bromo nicotinamide adenine dinucleotide; it is both a more potent antagonist than the 8-bromo derivative and has the advantage of chemical and ...
Bailey, Victoria C., Potter, Barry V.L., Sethi, Jaswinder K., Galione, Antony   +3 more
core   +1 more source

Metabolome analysis identified exogenous cholesterol within lipid rafts that activate the Akt/mTOR signaling pathway in epithelial ovarian cancer

International Journal of Cancer, Volume 159, Issue 1, Page 257-268, 1 July 2026.
What's New? Epithelial ovarian cancer (EOC) is a severe malignancy with few effective treatment options. While the mechanisms remain unclear, changes in lipid metabolism may fuel tumor growth and EOC progression, offering a possible path for new treatments.
Hitomi Sakaguchi‐Mukaida, Kosuke Hiramatsu, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Tadashi Iwamiya, Shinya Matsuzaki, Tetsuji Naka, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +10 more
wiley   +1 more source

Overactivation of poly(adenosine phosphate–ribose) polymerase 1 and molecular events in neuronal injury after deep hypothermic circulatory arrest: Study in a rabbit model

, 2007
ObjectiveAlthough deep hypothermic circulatory arrest has been known to induce neuronal injury, the molecular mechanism of this damage has not been identified.
Long, Cun, Tian, Liangxin, Liu, Ningning, Ma, Weiguo, Sun, Lizhong, Pan, Xudong, Feng, Zhengyi, Tang, Yue, Zheng, Jun   +8 more
core   +1 more source

7-Deaza cyclic adenosine 5′-diphosphate ribose: first example of a Ca2+-mobilizing partial agonist related to cyclic adenosine 5′-diphosphate ribose

, 1997
Background: Cyclic adenosine 5′-diphosphate ribose (cADPR), a naturally occurring metabolite of nicotinamide adenine dinucleotide (NAD+), mobilizes Ca2+ from non-mitochondria' stores in a variety of mammalian and invertebrate tissues.
Jaswinder K. Sethi, Fortt, Simon M., Simon M. Fortt, Antony Galione, Bailey, Victoria C., Potter, Barry V.L., Barry V.L. Potter, Sethi, Jaswinder K., Victoria C. Bailey, Galione, Antony   +9 more
core   +1 more source

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, Volume 30, Issue 3, Page 371-376, June 2026.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source

Purification and properties of glycohydrolase from calf thymus splitting ribose-ribose linkages of poly(adenosine diphosphate ribose).

Journal of Biological Chemistry, 1974
A new enzyme splitting the ribose-ribose bonds of poly-(adenosine diphosphate ribose) was purified 200-fold from calf thymus. The molecular weight of the enzyme was estimated to be 48,000 by gel filtration and 53,000 by sucrose density gradient ...
M. Miwa, M. Tanaka, T. Matsushima, T. Sugimura   +3 more
semanticscholar   +1 more source

Immunohistochemical demonstration of poly(adenosine diphosphate-ribose) in nuclei of various rat tissues.

, 1980
Natural distribution of poly(adenosine diphosphate-ribose), a novel macromolecule in eukaryotes, was investigated using an indirect immunofluorescence technique. The antibody, produced in a rabbit toward poly(ADP-ribose), was most reactive with polymers
K Ueda, O Hayaishi, K Ikai
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Studies on the polymer of adenosine diphosphate ribose. II. Characterization of the polymer.

Journal of Biological Chemistry, 1967
A particulate fraction from rat liver nuclei catalyzes polymerization of the adenosine diphosphate ribose moiety of nicotinamide adenine dinucleotide into an acid-insoluble polymer with the simultaneous release of nicotinamide.
Ronald H. Reeder, K. Ueda, Tasuku Honjo, Yasutomi Nishizuka, O. Hayaishi   +4 more
semanticscholar   +1 more source

Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5'-diphosphate ribose” [PDF]

, 2017
The multifunctional, transmembrane glycoprotein human CD38 catalyses the synthesis of three key Ca2+-mobilising messengers, including cyclic adenosine 5′-diphosphate ribose (cADPR), and CD38 knockout studies have revealed the relevance of the related ...
Graeff, Richard, Joanna M. Watt, Thomas, MP, Potter, BVL, Graeff, R, Thomas, Mark P., Watt, J, Richard Graeff, Mark P. Thomas, Watt, Joanna M, Potter, Barry, Barry V. L. Potter, Watt, Joanna   +12 more
core   +1 more source