Results 71 to 80 of about 34,973 (226)
Cellular Physiology and Biochemistry, 2015 Background/Aims: Adenosine diphosphate ribose (ADPR), a product of β-NAD+ metabolism generated by the multifunctional enzyme CD38, is recognized as a novel signaling molecule. The catalytic site of CD38 orients extracellularly or intracellularly, capable
Chun Huang +6 more
doaj +1 more source
Therapeutic Advances in Medical Oncology, 2020 Poly[adenosine diphosphate (ADP) ribose]polymerase (PARP) has multifaceted roles in the maintenance of genomic integrity, deoxyribonucleic acid (DNA) repair and replication, and the maintenance of immune-system homeostasis.
Elizabeth K. Lee +1 more
doaj +1 more source
PARP Inhibitors in First-Line Therapy of Ovarian Cancer: Are There Any Doubts?
Frontiers in Oncology, 2020 The standard of care for newly diagnosed advanced ovarian cancer (NADOC) is represented by surgical debulking followed by systemic platinum–taxanes combination chemotherapy.
Elisena Franzese +6 more
doaj +1 more source
Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1
Muscle &Nerve, EarlyView.ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno +5 more
wiley +1 more source
The plant Nudix hydrolase family. [PDF]
, 2008 Nudix hydrolases are a family of proteins defined by a conserved amino-acid sequence GX(5)-EX(7)REUXEEXGU, where U is a hydrophobic residue. These enzymes are widely distributed among all classes of organisms and catalyze, with varying degrees of ...
Kraszewska, Elzbieta
core
, 2016 A concise synthesis of five new analogues of the second messenger cADPR (cyclic adenosine 5‘-diphosphate ribose) is presented. The synthetic plan centered around the key derivative 8-Br-N1-cIDPR (cyclic 8-Br-inosine 5‘-diphosphate ribose, 2), which was ...
Gerd K. Wagner (423554) +2 more
core +1 more source
Host cell poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle. [PDF]
PLoS ONE, 2013 Trypanosoma cruzi, etiological agent of Chagas' disease, has a complex life cycle which involves the invasion of mammalian host cells, differentiation and intracellular replication. Here we report the first insights into the biological role of a poly(ADP-
Salomé C Vilchez Larrea +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Homologous recombination DNA repair (HR) is a complex DNA damage repair pathway and an attractive target of inhibition in anti-cancer therapy. To help guide the development of efficient HR inhibitors, it is critical to identify compensatory HR sub ...
Platon Selemenakis +7 more
doaj +1 more source
Total Synthesis of a Cyclic Adenosine 5′-Diphosphate Ribose Receptor Agonist
, 2015 Stable cyclic adenosine 5′-diphosphate ribose (cADPR) analogues are chemical biology tools that can probe the Ca2+ release mechanism and structure–activity relationships of this emerging potent second messenger.
Joanna M. Swarbrick (1285617) +1 more
core +1 more source
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source