Results 51 to 60 of about 144,925 (192)
Cellular Physiology and Biochemistry, 2015 Background/Aims: Adenosine diphosphate ribose (ADPR), a product of β-NAD+ metabolism generated by the multifunctional enzyme CD38, is recognized as a novel signaling molecule. The catalytic site of CD38 orients extracellularly or intracellularly, capable
Chun Huang +6 more
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PARP Inhibitors in First-Line Therapy of Ovarian Cancer: Are There Any Doubts?
Frontiers in Oncology, 2020 The standard of care for newly diagnosed advanced ovarian cancer (NADOC) is represented by surgical debulking followed by systemic platinum–taxanes combination chemotherapy.
Elisena Franzese +6 more
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The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
, 2016 An optimized synthetic route to 7-deaza-8-bromo-cyclic adenosine 5‘-diphosphate ribose (7-deaza-8-bromo-cADPR 3), an established cell-permeant, hydrolysis-resistant cyclic adenosine 5‘-diphosphate ribose (cADPR) antagonist, is presented.
Victoria C. Bailey (2450602) +2 more
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7-Deaza cyclic adenosine 5′-diphosphate ribose: first example of a Ca2+-mobilizing partial agonist related to cyclic adenosine 5′-diphosphate ribose [PDF]
, 1997 Background: Cyclic adenosine 5′-diphosphate ribose (cADPR), a naturally occurring metabolite of nicotinamide adenine dinucleotide (NAD+), mobilizes Ca2+ from non-mitochondria' stores in a variety of mammalian and invertebrate tissues.
Jaswinder K. Sethi +9 more
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PHOSPHONIC ACID ANALOGS OF ADENOSINE-DIPHOSPHATE AND ADENOSINE-TRIPHOSPHATE.
, 1963 PHOSPHONIC ACID ANALOGS OF ADENOSINE-DIPHOSPHATE AND ADENOSINE ...
ALBERT BABA. DANIELZADEH (7953785)
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Therapeutic Advances in Medical Oncology, 2020 Poly[adenosine diphosphate (ADP) ribose]polymerase (PARP) has multifaceted roles in the maintenance of genomic integrity, deoxyribonucleic acid (DNA) repair and replication, and the maintenance of immune-system homeostasis.
Elizabeth K. Lee +1 more
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Host cell poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle. [PDF]
PLoS ONE, 2013 Trypanosoma cruzi, etiological agent of Chagas' disease, has a complex life cycle which involves the invasion of mammalian host cells, differentiation and intracellular replication. Here we report the first insights into the biological role of a poly(ADP-
Salomé C Vilchez Larrea +5 more
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Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Background Low energy diets (LEDs) are effective for body weight (BW) loss and improvement of type 2 diabetes (T2D) risk biomarkers. Emerging evidence suggests that whole fruit feijoa powder, rich in polyphenols and abscisic acid, may further support T2D prevention.
I. A. Mohamed +6 more
wiley +1 more source
, 1983 The inter- and intracellular localization of poly(adenosine diphosphate-ribose)(poly(ADP-ribose] synthetase was investigated using an indirect immunofluorescence technique and a specific antibody against the enzyme purified from calf thymus.
K Ueda, K Ikai
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