Results 51 to 60 of about 34,973 (226)
Poly(adenosine diphosphate ribose) polymerase in Physarum polycephalum [PDF]
Biochemical Journal, 1975 1. The isolated nuclei of the slime mould Physarum polycephalum contain an enzyme that will incorporated [adenine-3H] NAD+ into an acid-insoluble product, which is shown to be poly(ADP-ribose). 2. This incorporation has an optimum pH of 8.2 and a temperature optimum below 10degreesC. 3. Optimum stimulation is given by 15 mM-Mg2+. 4.
M D, Brightwell +4 more
openaire +2 more sources
Role of Poly Adenosine Diphosphate Ribose Polymerase Inhibitors in Advanced Stage Ovarian Cancer. [PDF]
Cureus, 2018 Ovarian cancer is one of the leading causes of death from gynecologic cancers. In this present era of cancer treatment, therapeutic options for patients with advanced or recurrent ovarian cancer are limited.
Arora E +5 more
europepmc +2 more sources
Emerging Concepts on the Role of ADP-Ribosylation
Challenges, 2020 NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways, since it acts as a key regulator of cellular and organism homeostasis.
Palmiro Poltronieri
doaj +1 more source
Anti-tumour and radiosensitising effects of PARP inhibitor on cervical cancer xenografts
Journal of Obstetrics and Gynaecology, 2023 This study evaluated the radiosensitising effect of niraparib; a poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor on HeLa cervical cancer cells in nude mice and explored its possible mechanism.
Qin Xue +5 more
doaj +1 more source
Roles of Nicotinamide Adenine Dinucleotide (NAD+) in Biological Systems
Challenges, 2018 NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways since it acts as a key regulator of cellular and organism homeostasis. NAD+ is a coenzyme in redox reactions, a donor of adenosine diphosphate-ribose (ADPr) moieties in ADP-
Palmiro Poltronieri, Nataša Čerekovic
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Two cases of CRPC with BRCA mutation treated by olaparib after favorable response to cisplatin
IJU Case Reports, 2023 Introduction Several prostate cancers carry homologous recombination repair mutations that respond to olaparib. Because of the mechanism, the efficacy of platinum‐based therapy can be used to predict the efficacy of poly(adenosine diphosphate‐ribose ...
Yoshiyuki Miyazawa +9 more
doaj +1 more source
Journal of Medical Case Reports, 2018 Background Definite diagnosis of metastasis from unknown primary depends on a comprehensive immunohistochemical investigation of tumor specimen. Accurate identification of the origin site usually helps a lot in choosing the most appropriate treatment ...
Frank S. Fan, Chung-Fan Yang
doaj +1 more source
Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma–Induced Cancer Cachexia
Frontiers in Pharmacology, 2021 Nicotinamide riboside (NR), vitamin B3, is a substrate for nicotinamide adenine dinucleotide (NAD+)–consuming enzymes and is a coenzyme for hydride-transfer enzymes, including adenosine diphosphate (ADP)–ribose transferases, poly (ADP-ribose) polymerases,
Jong Min Park +5 more
doaj +1 more source
, 2023 Recently, Fong et al reported the antitumor activity of the poly(adenosine diphosphate)-ribose polymerase (PARP) inhibitor olaparib (AZD2281; KU-0059436) in patients with BRCA1/BRCA2 germline mutated ovarian cancer.
Herman, James G. +7 more
core +1 more source
Medicinal research reviews (Print)Breast cancer (BC) is a highly heterogeneous disease, and the presence of germline breast cancer gene mutation (gBRCAm) is associated with a poor prognosis. Triple‐negative breast cancer (TNBC) is a BC subtype, characterized by the absence of hormone and
P. Yuan, Nan Ma, Binghe Xu
semanticscholar +1 more source