Results 41 to 50 of about 34,973 (226)

Development of Single-Molecule Electrical Identification Method for Cyclic Adenosine Monophosphate Signaling Pathway

Nanomaterials, 2021
Cyclic adenosine monophosphate (cAMP) is an important research target because it activates protein kinases, and its signaling pathway regulates the passage of ions and molecules inside a cell.
Yuki Komoto, Takahito Ohshiro, Masateru Taniguchi   +2 more
doaj   +1 more source

Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application [PDF]

Exploration of Drug Science
Pentafuranosylnucleos(t)ides represent a class of natural compounds regulating diverse cell functions being preferably components of biopolymers and also participating as cyclic regulatory low-molecular ligands.
Dmitrii Platov, Anna Kozlova, Cyril Alexeev, Mikhail Drenichev   +3 more
doaj   +1 more source

ADP-ribosyl-N3: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds

Molecules, 2017
Adenosine diphosphate-ribose (ADP-ribose) and its derivatives play important roles in a series of complex physiological procedures. The design and synthesis of artificial ADP-ribosylated compounds is an efficient way to develop valuable chemical biology ...
Lingjun Li, Qianqian Li, Shengqiang Ding, Pengyang Xin, Yuqin Zhang, Shenlong Huang, Guisheng Zhang   +6 more
doaj   +1 more source

Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38 [PDF]

, 2014
Cyclic adenosine 5′-diphosphate ribose (cADPR) analogs based on the cyclic inosine 5′-diphosphate ribose (cIDPR) template were synthesized by recently developed stereo- and regioselective N1-ribosylation.
Graeff, Richard, Graeff, RM, Hao, Q, Thomas, MP, Swarbrick, Joanna M., Mark P. Thomas (423555), Potter, BVL, Quan Hao (67204), Thomas, Mark P., Zhang, Hongmin, Potter, Barry V L, Hao, Quan, Swarbrick, JM, Hongmin Zhang (1340733), Joanna M. Swarbrick (1285617), Barry V. L. Potter (286876), Zhang, H, Richard Graeff (423553)   +17 more
core   +1 more source

Recurrent Cervical Cancer Treated Successfully with Single-Agent PARP-Inhibitor, Olaparib

Case Reports in Obstetrics and Gynecology, 2022
Recurrent cervical cancer has a grim prognosis with 5-year survival
Maya Gross, Ryan J. Spencer
doaj   +1 more source

Inhibition of poly(adenosine diphosphate-ribose) polymerase attenuates ventilator-induced lung injury

, 2008
BACKGROUND: Mechanical ventilation can induce organ injury associated with overwhelming inflammatory responses. Excessive activation of poly(adenosine diphosphate-ribose) polymerase enzyme after massive DNA damage may aggravate inflammatory responses ...
de Corte, F., Juco, J.W., Uhlig, S., Vaschetto, R, Uhlig, S, Juco, JW, Kuiper, JW, Haitsma, J.J., Corte, F Della, Vaschetto, R.R., Haitsma, JJ, tz, FB Plö, Kuiper, J.W., Chiang, S.R., Slutsky, A.S., Plotz, F.B., Chiang, SR, Zhang, H., Zhang, H, Slutsky, AS   +19 more
core   +2 more sources

Role of APD-Ribosylation in Bone Health and Disease

Cells, 2019
The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD+) to acceptor proteins is known as ADP-ribosylation.
Chun Wang, Gabriel Mbalaviele
doaj   +1 more source

Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives. [PDF]

PLoS ONE, 2012
Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, thereby reversing the effects of poly(ADP-ribose) polymerases.
Julie A Tucker, Neil Bennett, Claire Brassington, Stephen T Durant, Giles Hassall, Geoff Holdgate, Mark McAlister, J Willem M Nissink, Caroline Truman, Martin Watson   +9 more
doaj   +1 more source

Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation. [PDF]

PLoS Biology, 2016
The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage.
Xin Sun, Kai Fu, Andrea Hodgson, Eric M Wier, Matthew G Wen, Olena Kamenyeva, Xue Xia, Lily Y Koo, Fengyi Wan   +8 more
doaj   +1 more source

Identification of PARP12 Inhibitors By Virtual Screening and Molecular Dynamics Simulations

Frontiers in Pharmacology, 2022
Poly [adenosine diphosphate (ADP)-ribose] polymerases (PARPs) are members of a family of 17 enzymes that performs several fundamental cellular processes.
Tahani M. Almeleebia, Shahzaib Ahamad, Irfan Ahmad, Ahmad Alshehri, Ali G. Alkhathami, Mohammad Y. Alshahrani, Mohammed A. Asiri, Amir Saeed, Amir Saeed, Jamshaid Ahmad Siddiqui, Dharmendra K. Yadav, Mohd Saeed   +11 more
doaj   +1 more source