Results 21 to 30 of about 144,925 (192)

ADP-Ribosylation in Antiviral Innate Immune Response

Pathogens, 2023
Adenosine diphosphate (ADP)-ribosylation is a reversible post-translational modification catalyzed by ADP-ribosyltransferases (ARTs). ARTs transfer one or more ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to the target substrate and release ...
Qian Du, Ying Miao, Wei He, Hui Zheng
doaj   +1 more source

Development of Single-Molecule Electrical Identification Method for Cyclic Adenosine Monophosphate Signaling Pathway

Nanomaterials, 2021
Cyclic adenosine monophosphate (cAMP) is an important research target because it activates protein kinases, and its signaling pathway regulates the passage of ions and molecules inside a cell.
Yuki Komoto, Takahito Ohshiro, Masateru Taniguchi   +2 more
doaj   +1 more source

Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors [PDF]

, 2011
The extent to which brain slices reflect the energetic status of the in vivo brain has been a subject of debate. We addressed this issue to investigate the recovery of energetic parameters and adenine nucleotides in rat hippocampal slices and the ...
D. Grahame Hardie, Hardie, D. G. (D. Grahame), Naomi Pentland, Simon Hawley, Frenguelli, Bruno, Doney, Alexander S., Pentland, Naomi, Frenguelli, Bruno G., Stephanie zur Nedden, Hawley, Simon, Alexander S. Doney, Bruno G. Frenguelli, Hardie, D. Grahame, Doney, Alexander S.; id_orcid, Zur Nedden, Stephanie   +14 more
core   +1 more source

Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application [PDF]

Exploration of Drug Science
Pentafuranosylnucleos(t)ides represent a class of natural compounds regulating diverse cell functions being preferably components of biopolymers and also participating as cyclic regulatory low-molecular ligands.
Dmitrii Platov, Anna Kozlova, Cyril Alexeev, Mikhail Drenichev   +3 more
doaj   +1 more source

ADP-ribosyl-N3: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds

Molecules, 2017
Adenosine diphosphate-ribose (ADP-ribose) and its derivatives play important roles in a series of complex physiological procedures. The design and synthesis of artificial ADP-ribosylated compounds is an efficient way to develop valuable chemical biology ...
Lingjun Li, Qianqian Li, Shengqiang Ding, Pengyang Xin, Yuqin Zhang, Shenlong Huang, Guisheng Zhang   +6 more
doaj   +1 more source

Recurrent Cervical Cancer Treated Successfully with Single-Agent PARP-Inhibitor, Olaparib

Case Reports in Obstetrics and Gynecology, 2022
Recurrent cervical cancer has a grim prognosis with 5-year survival
Maya Gross, Ryan J. Spencer
doaj   +1 more source

Role of APD-Ribosylation in Bone Health and Disease

Cells, 2019
The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD+) to acceptor proteins is known as ADP-ribosylation.
Chun Wang, Gabriel Mbalaviele
doaj   +1 more source

Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives. [PDF]

PLoS ONE, 2012
Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, thereby reversing the effects of poly(ADP-ribose) polymerases.
Julie A Tucker, Neil Bennett, Claire Brassington, Stephen T Durant, Giles Hassall, Geoff Holdgate, Mark McAlister, J Willem M Nissink, Caroline Truman, Martin Watson   +9 more
doaj   +1 more source

Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38 [PDF]

, 2014
Cyclic adenosine 5′-diphosphate ribose (cADPR) analogs based on the cyclic inosine 5′-diphosphate ribose (cIDPR) template were synthesized by recently developed stereo- and regioselective N1-ribosylation.
Graeff, Richard, Graeff, RM, Hao, Q, Thomas, MP, Swarbrick, Joanna M., Mark P. Thomas (423555), Potter, BVL, Quan Hao (67204), Thomas, Mark P., Zhang, Hongmin, Potter, Barry V L, Hao, Quan, Swarbrick, JM, Hongmin Zhang (1340733), Joanna M. Swarbrick (1285617), Barry V. L. Potter (286876), Zhang, H, Richard Graeff (423553)   +17 more
core   +1 more source

Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation. [PDF]

PLoS Biology, 2016
The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage.
Xin Sun, Kai Fu, Andrea Hodgson, Eric M Wier, Matthew G Wen, Olena Kamenyeva, Xue Xia, Lily Y Koo, Fengyi Wan   +8 more
doaj   +1 more source