ADP-Ribosylation in Antiviral Innate Immune Response
Pathogens, 2023 Adenosine diphosphate (ADP)-ribosylation is a reversible post-translational modification catalyzed by ADP-ribosyltransferases (ARTs). ARTs transfer one or more ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to the target substrate and release ...
Qian Du, Ying Miao, Wei He, Hui Zheng
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Nanomaterials, 2021 Cyclic adenosine monophosphate (cAMP) is an important research target because it activates protein kinases, and its signaling pathway regulates the passage of ions and molecules inside a cell.
Yuki Komoto +2 more
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Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application [PDF]
Exploration of Drug SciencePentafuranosylnucleos(t)ides represent a class of natural compounds regulating diverse cell functions being preferably components of biopolymers and also participating as cyclic regulatory low-molecular ligands.
Dmitrii Platov +3 more
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ADP-ribosyl-N3: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds
Molecules, 2017 Adenosine diphosphate-ribose (ADP-ribose) and its derivatives play important roles in a series of complex physiological procedures. The design and synthesis of artificial ADP-ribosylated compounds is an efficient way to develop valuable chemical biology ...
Lingjun Li +6 more
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Recurrent Cervical Cancer Treated Successfully with Single-Agent PARP-Inhibitor, Olaparib
Case Reports in Obstetrics and Gynecology, 2022 Recurrent cervical cancer has a grim prognosis with 5-year survival
Maya Gross, Ryan J. Spencer
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Role of APD-Ribosylation in Bone Health and Disease
Cells, 2019 The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD+) to acceptor proteins is known as ADP-ribosylation.
Chun Wang, Gabriel Mbalaviele
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Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives. [PDF]
PLoS ONE, 2012 Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, thereby reversing the effects of poly(ADP-ribose) polymerases.
Julie A Tucker +9 more
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Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation. [PDF]
PLoS Biology, 2016 The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage.
Xin Sun +8 more
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Identification of PARP12 Inhibitors By Virtual Screening and Molecular Dynamics Simulations
Frontiers in Pharmacology, 2022 Poly [adenosine diphosphate (ADP)-ribose] polymerases (PARPs) are members of a family of 17 enzymes that performs several fundamental cellular processes.
Tahani M. Almeleebia +11 more
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Anti-tumour and radiosensitising effects of PARP inhibitor on cervical cancer xenografts
Journal of Obstetrics and Gynaecology, 2023 This study evaluated the radiosensitising effect of niraparib; a poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor on HeLa cervical cancer cells in nude mice and explored its possible mechanism.
Qin Xue +5 more
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