Blocking Cyclic Adenosine Diphosphate Ribose-mediated Calcium Overload Attenuates Sepsis-induced Acute Lung Injury in Rats [PDF]
Chinese Medical Journal, 2016 Background: Acute lung injury (ALI) is a common complication of sepsis that is associated with high mortality. Intracellular Ca2+ overload plays an important role in the pathophysiology of sepsis-induced ALI, and cyclic adenosine diphosphate ribose ...
Qian-Yi Peng +5 more
doaj +4 more sources
Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy [PDF]
Biomolecules, 2012 Treatments with Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors have offered patients carrying cancers with mutated BRCA1 or BRCA2 genes a new and in many cases effective option for disease control.
Thomas Helleday, Cecilia E. Ström
doaj +5 more sources
A pan‐tumor review of the role of poly(adenosine diphosphate ribose) polymerase inhibitors [PDF]
Ca-A Cancer Journal for CliniciansPoly(adenosine diphosphate ribose) polymerase (PARP) inhibitors, such as olaparib, talazoparib, rucaparib, and niraparib, comprise a therapeutic class that targets PARP proteins involved in DNA repair.
Chadi Hage Chehade +2 more
exaly +4 more sources
4-Thioribose Analogues of Adenosine Diphosphate Ribose (ADPr) Peptides. [PDF]
Org Lett, 2023 Adenosine diphosphate (ADP) ribosylation is an important post-translational modification (PTM) that plays a role in a wide variety of cellular processes. To study the enzymes responsible for the establishment, recognition, and removal of this PTM, stable analogues are invaluable tools.
Madern JM +7 more
europepmc +9 more sources
Expression of poly(Adenosine Diphosphate-Ribose) polymerase protein in breast cancer [PDF]
Journal of Mid-Life Health, 2022 Background: The use of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors for breast cancer (BC) therapy is the subject of debate, and there is an urgent need to understand much the expression and prognostic role of the PARP1 protein.
Akanksha +6 more
doaj +4 more sources
Prognostic and clinicopathological value of poly (adenosine diphosphate-ribose) polymerase expression in breast cancer: A meta-analysis. [PDF]
PLoS ONE, 2017 BACKGROUND:Previous studies have shown that the poly (adenosine diphosphate-ribose) polymerase (PARP) level is a promising indicator of breast cancer. However, its prognostic value remains controversial. The present meta-analysis evaluated the prognostic
Weiqiang Qiao +4 more
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Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy‐mediated drug resistance in ovarian cancer cells, xenografts, and patient‐derived xenograft models [PDF]
Cancer, 2020 Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors exhibit promising activity against ovarian cancers, but their efficacy can be limited by acquired drug resistance.
S John Weroha +2 more
exaly +3 more sources
Poly(Adenosine diphosphate-ribose) polymerase inhibitors in cancer treatment. [PDF]
Hematol Oncol Clin North Am, 2012 Recently, the development of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors as a synthetic lethality approach has brought a major breakthrough in the treatment of breast cancer susceptibility gene (BRCA)-mutant cancers. Because sporadic cancers have also been found to commonly have other defects in DNA repair, PARP inhibitors are under
Park SR, Chen A.
europepmc +5 more sources
Synthesis of terminal ribose analogues of adenosine 5'-diphosphate ribose (ADPR) as probes for the Transient Receptor Potential (TRP) cation channel TRPM2 [PDF]
Journal of Organic Chemistry, 2019 TRPM2 (transient receptor potential cation channel, subfamily M, member 2) is a non-selective cation channel involved in the response to oxidative stress and in inflammation.
O. Baszczyňski +5 more
semanticscholar +4 more sources
Vascular Protection of Poly(ADP-ribose) Polymerase Inhibitors in the Combination Therapy With Vascular Endothelial Growth Factor Signaling Pathway Inhibitors [PDF]
Reviews in Cardiovascular MedicineThe Poly(ADP-ribose) polymerase (PARP) family comprises seventeen members that catalyze poly- or mono- adenosine diphosphate (ADP)-ribosylation, a pivotal post-translational modification regulating a wide array of cellular processes, including ...
Jie Ma +8 more
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