Results 31 to 40 of about 13,187 (171)

Emerging Concepts on the Role of ADP-Ribosylation

Challenges, 2020
NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways, since it acts as a key regulator of cellular and organism homeostasis.
Palmiro Poltronieri
doaj   +1 more source

Roles of Nicotinamide Adenine Dinucleotide (NAD+) in Biological Systems

Challenges, 2018
NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways since it acts as a key regulator of cellular and organism homeostasis. NAD+ is a coenzyme in redox reactions, a donor of adenosine diphosphate-ribose (ADPr) moieties in ADP-
Palmiro Poltronieri, Nataša Čerekovic
doaj   +1 more source

Two cases of CRPC with BRCA mutation treated by olaparib after favorable response to cisplatin

IJU Case Reports, 2023
Introduction Several prostate cancers carry homologous recombination repair mutations that respond to olaparib. Because of the mechanism, the efficacy of platinum‐based therapy can be used to predict the efficacy of poly(adenosine diphosphate‐ribose ...
Yoshiyuki Miyazawa, Takanori Shimizu, Yoshitaka Sekine, Seiji Arai, Akira Ohtsu, Yuji Fujizuka, Masashi Nomura, Hidekazu Koike, Hiroshi Matsui, Kazuhiro Suzuki   +9 more
doaj   +1 more source

Poly(adenosine diphosphate ribose) polymerase in Physarum polycephalum [PDF]

Biochemical Journal, 1975
1. The isolated nuclei of the slime mould Physarum polycephalum contain an enzyme that will incorporated [adenine-3H] NAD+ into an acid-insoluble product, which is shown to be poly(ADP-ribose). 2. This incorporation has an optimum pH of 8.2 and a temperature optimum below 10degreesC. 3. Optimum stimulation is given by 15 mM-Mg2+. 4.
M D, Brightwell, C E, Leech, M K, O'Farrell, W J, Whish, S, Shall   +4 more
openaire   +2 more sources

Complete response to orally administered melphalan in malignant pleural effusion from an occult female genital organ primary neoplasm with BRCA1/2 mutations: a case report

Journal of Medical Case Reports, 2018
Background Definite diagnosis of metastasis from unknown primary depends on a comprehensive immunohistochemical investigation of tumor specimen. Accurate identification of the origin site usually helps a lot in choosing the most appropriate treatment ...
Frank S. Fan, Chung-Fan Yang
doaj   +1 more source

Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma–Induced Cancer Cachexia

Frontiers in Pharmacology, 2021
Nicotinamide riboside (NR), vitamin B3, is a substrate for nicotinamide adenine dinucleotide (NAD+)–consuming enzymes and is a coenzyme for hydride-transfer enzymes, including adenosine diphosphate (ADP)–ribose transferases, poly (ADP-ribose) polymerases,
Jong Min Park, Young Min Han, Ho Jae Lee, Yong Jin Park, Ki Baik Hahm, Ki Baik Hahm   +5 more
doaj   +1 more source

The Current State of the Art in PARP Inhibitor-Based Delivery Nanosystems

Pharmaceutics, 2022
Poly (adenosine diphosphate [ADP]–ribose) polymerases inhibitors (PARPi), the first clinically approved drug that exhibits synthetic lethality, are moving to the forefront of cancer treatments.
Lisha Cai, Xiaoling Xu, Wei Chen
doaj   +1 more source

Synthesis of Adenosine Diphosphate Ribose Histidine

Organic Letters
Adenosine diphosphate ribosylated histidine (His-ADPr) is a vital signaling molecule for the bacterial immune system, the antiphage system in particular. In this unique second messenger molecule, the distal nitrogen of the histidine side chain is ribosylated in a β fashion.
Bob van Puffelen, Yang Lu, Hugo Minnee, Marion Schuller, Gijsbert A. van der Marel, Ivan Ahel, Jeroen D. C. Codée, Dmitri V. Filippov   +7 more
openaire   +4 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Current Treatments and New Possible Complementary Therapies for Epithelial Ovarian Cancer

Biomedicines, 2021
Epithelial ovarian cancer (EOC) is one of the deadliest gynaecological malignancies. The late diagnosis is frequent due to the absence of specific symptomatology and the molecular complexity of the disease, which includes a high angiogenesis potential ...
Maritza P. Garrido, Allison N. Fredes, Lorena Lobos-González, Manuel Valenzuela-Valderrama, Daniela B. Vera, Carmen Romero   +5 more
doaj   +1 more source