Results 11 to 20 of about 165,902 (383)

Structure of Klebsiella pneumoniae adenosine monophosphate nucleosidase. [PDF]

PLoS One, 2022
Klebsiella pneumoniae is a bacterial pathogen that is increasingly responsible for hospital-acquired pneumonia and sepsis. Progressive development of antibiotic resistance has led to higher mortality rates and creates a need for novel treatments. Because of the essential role that nucleotides play in many bacterial processes, enzymes involved in purine
Richardson BC, Shek R, Van Voorhis WC, French JB.   +3 more
europepmc   +6 more sources

U-shaped association between plasma cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) levels and myocardial infarction. [PDF]

BMC Cardiovasc Disord
Background The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway is closely associated with myocardial infarction (MI).
Zhang Q, Ding H, Dai Z, Yang R, Zhou S, Tai S.   +5 more
europepmc   +2 more sources

Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. [PDF]

PLoS ONE, 2016
RATIONALE:Decreased alkaline phosphatase activity after infant cardiac surgery is associated with increased post-operative cardiovascular support requirements. In adults undergoing coronary artery bypass grafting, alkaline phosphatase infusion may reduce
Jesse A Davidson, Tracy Urban, Suhong Tong, Mark Twite, Alan Woodruff, Paul E Wischmeyer, Jelena Klawitter   +6 more
doaj   +1 more source

Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia [PDF]

Mater. Sci. Eng. C. 91, 340-348 (2018), 2021
Nanographene oxide (nGO)-mediated hyperthermia has been increasingly investigated as a localised, minimally invasive anticancer therapeutic approach. Near InfraRed (NIR) light irradiation for inducing hyperthermia is particularly attractive, because biological systems mostly lack chromophores that absorb in this spectral window, facilitating the ...
arxiv   +1 more source

Metformin promotes angiogenesis and functional recovery in aged mice after spinal cord injury by adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway

Neural Regeneration Research, 2023
Treatment with metformin can lead to the recovery of pleiotropic biological activities after spinal cord injury. However, its effect on spinal cord injury in aged mice remains unclear.
Jin-Yun Zhao, Xiao-Long Sheng, Cheng-Jun Li, Tian Qin, Run-Dong He, Guo-Yu Dai, Yong Cao, Hong-Bin Lu, Chun-Yue Duan, Jian-Zhong Hu   +9 more
doaj   +1 more source

Selective Fluorimetric Detection of Pyrimidine Nucleotides in Neutral Aqueous Solution with a Styrylpyridine-Based Cyclophane

Chemistry, 2023
A styrylpyridine-containing cyclophane with diethylenetriamine linkers is presented as a host system whose association with representative nucleotides was examined with photometric and fluorimetric titrations.
Julika Schlosser, Julian F. M. Hebborn, Daria V. Berdnikova, Heiko Ihmels   +3 more
doaj   +1 more source

A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling

Nature Communications, 2021
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) is normally induced by innate immunity sensing for protection from pathogens. Here the authors show that cGAMP is also upstream of DNA damage signaling by activating ATM-CHK2-mediated repair ...
Daipayan Banerjee, Kurt Langberg, Salar Abbas, Eric Odermatt, Praveen Yerramothu, Martin Volaric, Matthew A. Reidenbach, Kathy J. Krentz, C. Dustin Rubinstein, David L. Brautigan, Tarek Abbas, Bradley D. Gelfand, Jayakrishna Ambati, Nagaraj Kerur   +13 more
doaj   +1 more source

Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing

Frontiers in Immunology, 2021
Innate immune pathways are the first line of cellular defense against pathogen infections ranging from bacteria to Metazoa. These pathways are activated following the recognition of pathogen associated molecular patterns (PAMPs) by membrane and cytosolic
Eloi R. Verrier, Christelle Langevin
doaj   +1 more source

Dietary intake of fructose increases purine de novo synthesis: A crucial mechanism for hyperuricemia

Frontiers in Nutrition, 2022
BackgroundFructose consumption is a potential risk factor for hyperuricemia because uric acid (UA) is a byproduct of fructose metabolism caused by the rapid consumption of adenosine triphosphate and accumulation of adenosine monophosphate (AMP) and other
Pengfei Zhang, Pengfei Zhang, Huimin Sun, Xinyu Cheng, Yajing Li, Yanli Zhao, Wuxuan Mei, Xing Wei, Hairong Zhou, Yunbo Du, Changchun Zeng   +10 more
doaj   +1 more source

Neointima formation is promoted by surgical preparation and inhibited by cyclic nucleotides in human saphenous vein organ cultures [PDF]

, 1995
Intimal thickening is an important cause of late coronary vein graft occlusion, which no variation of surgical technique or pharmacologic intervention has been shown to reduce.
Angelini, Gianni D., Newby, Andrew C., Soyombo, Abigail A.   +2 more
core   +1 more source