Adenosine Receptor mRNA Expression in Frontal Cortical Neurons in Schizophrenia. [PDF]
Cells, 2023 Sahay S +3 more
europepmc +1 more source
Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism
Advanced Science, EarlyView.Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang +4 more
wiley +1 more source
Evidence for an atypical receptor mediating the augmented bronchoconstrictor response to adenosine induced by allergen challenge in actively sensitized Brown Norway rats [PDF]
, 2002 Jason Hannon +6 more
openalex +1 more source
Advanced Science, EarlyView.Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li +14 more
wiley +1 more source
Novel Adenosine Receptor Antagonists for Treating Cancer and Immune-Related Disorders. [PDF]
ACS Med Chem Lett, 2023 Sabnis RW.
europepmc +1 more source
The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist
Science, 2008 Veli-Pekka Jaakola +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li +11 more
wiley +1 more source
Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. [PDF]
, 1996 Ariane Mallat +12 more
openalex +1 more source
A1 adenosine receptor activation inhibits P2X3 receptor-mediated ATP currents in rat dorsal root ganglion neurons [PDF]
, 2022 Jia‐Wei Hao +7 more
openalex +1 more source
Advanced Science, EarlyView.Draper is evolutionarily conserved across most insect species. Loss of Draper inhibits autophagy activation, delaying middle silk gland degradation in the silkworm during metamorphosis. Draper interacts with autophagy ‐ related protein 3 (ATG3) to orchestrate autophagosome formation—a process essential for silk gland degradation during the larval‐pupal
Shiyu Zou +9 more
wiley +1 more source