Results 111 to 120 of about 4,325,962 (256)

Dual acting antioxidant A1 adenosine receptor agonists [PDF]

, 2007
Herein we report the synthesis and biological evaluation of some potent and selective A1 adenosine receptor agonists, which incorporate a functionalised linker attached to an antioxidant moiety.
Figler, Heidi, Urmaliya, Vijay, Scammells, Peter J., Pouton, Colin W., Linden, Joel, Gregg, Alison D., Devine, Shane M., White, Paul, Bottle, Steven E.   +8 more
core   +1 more source

Development of adenosine signalling in the cerebellum [PDF]

The release and clearance of adenosine are reasonably well-documented in the mature CNS but relatively little is known about how adenosine signalling changes during postnatal development.
Atterbury, Alison
core  

Therapeutic Potential Target of Adenosine for Epilepsy: Focusing on Its Interaction with the Molecular Epileptogenic Network

Biomolecules
Epilepsy is a neurological disorder characterized by a long-lasting predisposition to recurrently generate unprovoked seizures. Epilepsy affects over 70 million people worldwide, with approximately one-third suffering from pharmacoresistant seizures ...
Xiaoning Zhao, Jiahui Deng, Zhonghua Xiong, Tianfu Li   +3 more
doaj   +1 more source

Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. [PDF]

, 2011
Adenosine is involved in several neurological and behavioral disorders including alcoholism. In cultured cell and animal studies, type 1 equilibrative nucleoside transporter (ENT1, slc29a1), which regulates adenosine levels, is known to regulate ethanol ...
Hyung Wook Nam, Karpyak Victor M., Preuss Ulrich W., Peter Zill, Colin Colby, David A. Mrazek, Colby Colin, Biernacka Joanna M., Moonnoh R. Lee, Preuss, Ulrich W., Victor M. Karpyak, Lee, Moonnoh R., Kim, Jeong-Hyun, Kim Jeong-Hyun, Lee Moonnoh R., Zill, Peter, Jeong-Hyun Kim, Joanna M. Biernacka, Nam Hyung Wook, David A Mrazek, Gihyun Yoon, Moonnoh R Lee, Ulrich W. Preuss, Zill Peter, Colby, Colin, Doo-Sup Choi, Yoon, Gihyun, Joanna M Biernacka, Ulrich W Preuss, Mrazek, David A., Nam, Hyung Wook, Yoon Gihyun, Choi, Doo-Sup, Victor M Karpyak, Mrazek David A., Biernacka, Joanna M., Choi Doo-Sup, Karpyak, Victor M.   +37 more
core   +2 more sources

Blockade of the Adenosine 2A Receptor Mitigates the Cardiomyopathy Induced by Loss of Plakophilin-2 Expression

Frontiers in Physiology, 2018
Background: Mutations in plakophilin-2 (PKP2) are the most common cause of familial Arrhythmogenic Right Ventricular Cardiomyopathy, a disease characterized by ventricular arrhythmias, sudden death, and progressive fibrofatty cardiomyopathy. The relation
Marina Cerrone, Chantal J. M. van Opbergen, Kabir Malkani, Natasha Irrera, Natasha Irrera, Mingliang Zhang, Toon A. B. Van Veen, Bruce Cronstein, Mario Delmar   +8 more
doaj   +1 more source

Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

Molecular Pharmacology, 1986
[3H]NECA (1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuronamide) is known to bind to both the A1 and A2 subtypes of adenosine receptor in rat striatal membranes.
R. Bruns, G. Lu, T. Pugsley
semanticscholar   +1 more source

Pharmacological and Therapeutic Effects of A3 Adenosine Receptor (A3AR) Agonists

Drug Discovery Today, 2011
The Gi-coupled A3 adenosine receptor (A3AR) mediates anti-inflammatory, anticancer and anti-ischemic protective effects. The receptor is overexpressed in inflammatory and cancer cells, while low expression is found in normal cells, rendering the A3AR as ...
P. Fishman, S. Bar‐Yehuda, B. Liang, K. Jacobson   +3 more
semanticscholar   +1 more source

Cardiovascular biology of the A3 adenosine receptor

, 2009
The goal of this chapter is to review current theories regarding the potential involvement of the A3 receptor in mediating the actions of adenosine in the cardiovascular system. The Gi protein-coupled A3 adenosine receptor is the last adenosine receptor
Kwok, Wai-Meng, Wan, Tina C, John A. Auchampach, Headrick, John P, John P. Headrick, Tina C. Wan, Jason N. Peart, Peart, Jason N, Auchampach, John A, Headrick, John, Peart, Jason, Wang, Tina, Wai-Meng Kwok, Auchampach, John   +13 more
core   +1 more source

Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine

The Journal of Headache and Pain, 2018
Background Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels ...
Kristian A. Haanes, Alejandro Labastida-Ramírez, Kayi Y. Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M. Flores, Alexander H. J. Danser, Carlos M. Villalón, Antoinette MaassenVanDenBrink   +10 more
doaj   +1 more source

Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis. [PDF]

, 2010
With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge, the ...
Jallow, Muminatou, Andrew E Fry, Angela Green, Taylor Terrie E., Haldar, Kasturi, Diakite, M, Haldar Kasturi, Kirk A Rockett, Kwiatkowski, DP, Taylor, Terrie E, Richardson, Anna, Fry, AE, Green, A, Kwiatkowski, Dominic, Sisay-Joof, Fatou, Dominic P Kwiatkowski, Kwiatkowski Dominic P., Taane G Clark, Pinder Margaret, Rockett, KA, Sisay-Joof, F, Molyneux, ME, Kasturi Haldar, Mahamadou Diakite, Sisay-Joof Fatou, Green Angela, Haldar, K, Campino, S, Auburn Sarah, Clark, Taane G, Clark, TG, Fry Andrew E., Molyneux, Malcolm E, Green, Angela, Campino Susana, Molyneux Malcolm E., Auburn, Sarah, Fatou Sisay-Joof, Pinder, M, Auburn, S, Susana Campino, Sarah Auburn, Diakite, Mahamadou, Rockett, Kirk A, Richardson, A, Muminatou Jallow, Fry, Andrew E, Richardson Anna, Jallow Muminatou, Anna Richardson, Jallow, M, Malcolm E Molyneux, Campino, Susana, Diakite Mahamadou, Rockett Kirk A., Clark Taane G., Taylor, TE, Margaret Pinder, Terrie E Taylor, Pinder, Margaret, Kwiatkowski, Dominic P   +60 more
core   +1 more source