Results 91 to 100 of about 4,325,962 (256)

NEW INSIGHTS AND POSSIBLE THERAPEUTIC IMPLICATIONS OF ADENOSINE ANALOGS AND PULSED ELECTROMAGNETIC FIELDS (PEMFs) IN OSTEOARTICULAR PATHOLOGIES [PDF]

, 2009
Objective: The aim of this study was to characterize adenosine receptors in synovial fibroblasts (SFs) and to investigate the potential link between adenosine pathway and pulsed electromagnetic fields (PEMFs).
Masieri, Federica Francesca
core  

In vivo co-ordinated interactions between inhibitory systems to control glutamate mediated hippocampal excitability. [PDF]

, 2013
We present an overview of the long-term adaptation of hippocampal neurotransmission to cholinergic and GABAergic deafferentation caused by excitotoxic lesion of the medial septum.
Rodríguez Allué, Manuel José, Robledo, Patricia, Mahy Gehenne, Josette Nicole, Andrade, Carmen   +3 more
core   +1 more source

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

Front. Immun., 2012
The A2A adenosine receptor (A2AR)-mediated immunosuppression is firmly implicated in the life-saving down-regulation of collateral tissue damage during the anti-pathogen immune response and in highly undesirable protection of cancerous tissues during ...
A. Ohta, R. Kini, Akiko Ohta, Meenakshi P. Subramanian, Manasa Madasu, M. Sitkovsky   +5 more
semanticscholar   +1 more source

Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

Cells, 2020
Adenosine is involved in a range of physiological and pathological effects through membrane-bound receptors linked to G proteins. There are four subtypes of adenosine receptors, described as A1AR, A2AAR, A2BAR, and A3AR, which are the center of cAMP ...
W. Effendi, T. Nagano, Kazuyuki Kobayashi, Y. Nishimura   +3 more
semanticscholar   +1 more source

Probe dependence of allosteric enhancers on the binding affinity of adenosine A1‐receptor agonists at rat and human A1‐receptors measured using NanoBRET [PDF]

, 2019
Background and Purpose: Adenosine is a local mediator that regulates a number of physiological and pathological processes via activation of adenosine A1‐receptors.
Samantha L. Cooper, Scammells, Peter J., Hill, Stephen J., Manuela Jörg, Jörg, Manuela, Cooper, Samantha L., Mark Soave, Woolard, Jeanette, Soave, Mark, Jeanette Woolard, Peter J. Scammells, Stephen J. Hill   +11 more
core   +1 more source

Impaired Inhibitory Function of Presynaptic A1-Adenosine Receptors in SHR Mesenteric Arteries

Journal of Pharmacological Sciences, 2013
In hypertension, vascular reactivity alterations have been attributed to numerous factors, including higher sympathetic innervation/adenosine. This study examined the modulation of adenosine receptors on vascular sympathetic nerves and their putative ...
Carolina Rocha-Pereira, Silvia Magdalena Arribas, Paula Fresco, Maria Carmen González, Jorge Gonçalves, Carmen Diniz   +5 more
doaj   +1 more source

Adenosine Receptors and Wound Healing, Revised

The Scientific World Journal, 2006
Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy ...
Bruce M. Cronstein
doaj   +1 more source

Adenosine A2A Receptor Deletion Blocks the Beneficial Effects of Lactobacillus reuteri in Regulatory T-Deficient Scurfy Mice

Frontiers in Immunology, 2017
The lack of a functional Foxp3 transcription factor and regulatory T (Treg) cells causes lethal, CD4+ T cell-driven autoimmune diseases in scurfy (SF) mice and humans.
Baokun He, Thomas K. Hoang, Dat Q. Tran, Jon Marc Rhoads, Yuying Liu   +4 more
doaj   +1 more source

Adenosine metabolism – emerging concepts for cancer therapy

Cancer Cell, 2019
Summary Adenosine is a key metabolic and immune checkpoint regulator implicated in the tumor escape from the host immune system. Major gaps in knowledge that impede the development of effective adenosine-based therapeutics include: (1) Lack of ...
D. Boison, G. Yegutkin
semanticscholar   +1 more source

Predictions for Cholesterol Interaction Sites on the A2A Adenosine Receptor

Journal of the American Chemical Society, 2012
Molecular dynamics simulations of the A2A adenosine receptor totaling 1.4 μsec show clear evidence for specific sites mediating interactions between adenosinebound A2A and cholesterol. The strongest evidence is for three binding sites.
J. Lee, E. Lyman
semanticscholar   +1 more source