Results 121 to 130 of about 2,801,899 (401)

A3 Adenosine Receptors Modulate Hypoxia-inducible Factor-1a Expression in Human A375 Melanoma Cells

Neoplasia: An International Journal for Oncology Research, 2005
Hypoxia-inducible factor-1 (HIF-1) is a key regulator of genes crucial to many aspects of cancer biology. The purine nucleoside, adenosine, accumulates within many tissues under hypoxic conditions, including that of tumors. Because the levels of both HIF-
Stefania Merighi, Annalisa Benini, Prisco Mirandola, Stefania Gessi, Katia Varani, Edward Leung, Stephen MacLennan, Pier Giovanni Baraldi, Pier Andrea Borea   +8 more
doaj   +1 more source

Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

Nature, 2021
C. Draper-Joyce, Rebecca F. Bhola, Jinan Wang, A. Bhattarai, A. T. Nguyen, India Cowie-Kent, Kelly O’Sullivan, Ling Yeong Chia, H. Venugopal, C. Valant, D. Thal, D. Wootten, Nicolas Panel, Jens Carlsson, M. Christie, P. White, P. Scammells, L. May, P. Sexton, R. Danev, Yinglong Miao, A. Glukhova, Wendy L. Imlach, A. Christopoulos   +23 more
semanticscholar   +1 more source

Near‐Infrared Organic Photovoltaic Electrodes for Subretinal Neurostimulation

Advanced Functional Materials, EarlyView.
Organic photovoltaic electrodes based on the D18:Y6 blend enable precise and light‐controlled activation of retinal ganglion cells in a degenerating retina. NIR Light‐driven activation of retinal ganglion cells, tunable stimulation parameters, and biocompatibility with human retinal organoids highlight their potential for next‐generation prosthetics ...
Andrea Corna, Katarina Gugujonovic, Manuela Schiek, Alessandro Bellapianta, Paul Werginz, Amelie Ziller, Markus Clark Scharber, Ahmad Salti, Matthias Bolz, Mihai Irimia‐Vladu, Günther Zeck   +10 more
wiley   +1 more source

Degranulation of rat omental mast cells by A1 receptor agonists in vitro

Mediators of Inflammation, 1996
The haemodynamic effects of adenosine are thought to result in part from a release of mast cell amines via A3 receptor stimulation. To investigate the nature of the receptors involved in adenosine-induced mast cell degranulation in the rat isolated ...
A. M. Northover, B. J. Northover
doaj   +1 more source

Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]

, 2008
Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core  

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

A1 adenosine receptor evoked Ca2+ signals in astrocytes

Current Directions in Biomedical Engineering
In addition to neurons, glial cells make up the nervous system. These glial cells are divided into macroglial cells - including astrocytes - and microglial cells.
Kienleitner Filip, Lenk Kerstin
doaj   +1 more source

Presynaptic adenosine receptor-mediated regulation of diverse thalamocortical short-term plasticity in the mouse whisker pathway [PDF]

, 2016
Short-term synaptic plasticity (STP) sets the sensitivity of a synapse to incoming activity and determines the temporal patterns that it best transmits.
Abbott, Agmon, Ariel, Armbruster, Baden, Bale, Beck, Beierlein, Blackman, Borgdorff, Boudreau, Branco, Branco, Bruno, Buonomano, Calloway, Carvalho, Castro-Alamancos, Castro-Alamancos, Chabrol, Cheetham, Chung, Covic, Crair, Cruikshank, Crunelli, David, Daw, de Jong, Dudek, Dunwiddie, Díaz-Quesada, Díaz-Quesada, Elmslie, Ermolyuk, Fioravante, Fioravante, Fontanez, Fortune, Francisco J. Martini, Gabernet, Gil, Gil, Giovanni Ferrati, Heiss, Hennig, Higley, Jouhanneau, Kandaswamy, Kerr, Kidd, Körber, Leal, Lee, Lee, Lerma, Lupica, McCormick, McCormick, Miguel Maravall, Mochida, Moore, Mulle, Mulle, Müller, Nicoll, Ollerenshaw, Pfister, Pologruto, Porter, Poulet, Reig, Ribrault, Rose, Scanziani, Shen, Sherman, Sippy, Slézia, Stratford, Sun, Sylwestrak, Urbain, Urbano, Viaene, Welzel, Wilent, Wu, Yang, Zhao, Zucker   +90 more
core   +2 more sources

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source