Results 121 to 130 of about 2,608,509 (268)

Carbamazepine Attenuates Astroglial L-Glutamate Release Induced by Pro-Inflammatory Cytokines via Chronically Activation of Adenosine A2A Receptor [PDF]

, 2019
Motohiro Okada, Kouji Fukuyama, Takashi Shiroyama, Yuto Ueda   +3 more
openalex   +1 more source

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

Advanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang, Yinghui Xu, Xianpeng Wu, Mo Li, Changchen Xiao, Zaiyang Fu, Yongjian Chen, Qingju Li, Yating Ruan, Jing Zhao, Zhiwei Zhong, Jinghai Chen, Wei Zhu, Jinliang Nan, Cheng Ni, Xinyang Hu   +15 more
wiley   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Structural Simplification from Tricyclic to Bicyclic Scaffolds: A Long-Term Investigation in the Field of Adenosine Receptor Antagonists. [PDF]

Cells
Ceni C, Calenda S, Vagnoni G, Catarzi D, Varano F, Colotta V.   +5 more
europepmc   +1 more source

Publisher Correction to: Adenosine receptor signalling in Alzheimer's disease. [PDF]

Purinergic Signal, 2022
Trinh PNH, Baltos JA, Hellyer SD, May LT, Gregory KJ.   +4 more
europepmc   +1 more source

AMP Is an Adenosine A 1 Receptor Agonist

, 2012
Joseph E. Rittiner, Ilia Korboukh, Emily A. Hull-Ryde, Jian Jin, William P. Janzen, Stephen V. Frye, Mark J. Zylka   +6 more
openalex   +2 more sources

Adenosine 2B Receptor Expression Is Post-transcriptionally Regulated by MicroRNA [PDF]

, 2010
Vasantha L. Kolachala, Lixin Wang, Tracy S. Obertone, Meena Prasad, Yutao Yan, Guillaume Dalmasso, Andrew T. Gewirtz, Didier Merlin, Shanthi V. Sitaraman   +8 more
openalex   +1 more source

Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer

Proceedings of the National Academy of Sciences of the United States of America, 2015
J. Bonaventura, Gemma Navarro, Verònica Casadó-Anguera, Karima Azdad, W. Rea, E. Moreno, Marc Brugarolas, J. Mallol, E. Canela, C. Lluis, Antonio Cortés, N. Volkow, S. Schiffmann, S. Ferré, V. Casadó   +14 more
semanticscholar   +1 more source

A Lipid with Lewis Pair‐Mediated Targeting and Multiple Stimuli‐Responsive Delivery of Antibiotics for Bacterial Infections

Advanced Science, EarlyView.
Lewis pair‐integrated lipids (Lp‐lipids), combining targeted delivery and stimuli‐responsive are developed for antibiotic delivery. These lipids form nanoparticles that bind biofilms via boronate ester bonds and respond to acidic pH, H2O2, and ATP, enabling controlled drug release.
Xiaojian Yan, Lei Hua, Hongping Wan, Yong Liu, Tao Jin, Yicen Ge, Michael R Hamblin, Mahdi Karimi, Xinghong Zhao, Yan Hu, Linqi Shi, Yuanfeng Li   +11 more
wiley   +1 more source

Structure-based discovery of positive allosteric modulators of the A₁ adenosine receptor. [PDF]

Proc Natl Acad Sci U S A
Nguyen ATN, Panel N, Vo DD, Thai BS, Chia LY, Lu CS, Hellyer SD, Langiu M, Jörg M, Gregory KJ, Kihlberg J, White PJ, Scammells PJ, Christopoulos A, Carlsson J, May LT.   +15 more
europepmc   +1 more source