Results 131 to 140 of about 2,608,509 (268)

Improving combination therapies: targeting A2B-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression. [PDF]

J Natl Cancer Inst, 2023
Evans JV, Suman S, Goruganthu MUL, Tchekneva EE, Guan S, Arasada RR, Antonucci A, Piao L, Ilgisonis I, Bobko AA, Driesschaert B, Uzhachenko RV, Hoyd R, Samouilov A, Amann J, Wu R, Wei L, Pallerla A, Ryzhov SV, Feoktistov I, Park KP, Kikuchi T, Castro J, Ivanova AV, Kanagasabai T, Owen DH, Spakowicz DJ, Zweier JL, Carbone DP, Novitskiy SV, Khramtsov VV, Shanker A, Dikov MM.   +32 more
europepmc   +1 more source

Succinic Acid‐Induced Macrophage Endocytosis Promotes Extracellular Vesicle‐Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis‐Associated Pulmonary Fibrosis

Advanced Science, EarlyView.
Lipopolysaccharide (LPS) stimulates the production of succinic acid in lung tissue, which promotes macrophages endocytosis and the formation of multivesicular bodies (MVBs). These MVBs release profibrotic extracellular vesicles (EVs), facilitating the transfer of integrin beta1 (ITGβ1) transfer and subsequently activating fibroblasts, thereby ...
Wenyu Yang, Ri Tang, Yang Zhou, Jinquan Zhang, Shuya Mei, Yawen Peng, Xi Huang, Shunpeng Xing, Yuan Gao, Qiaoyi Xu, Zhengyu He   +10 more
wiley   +1 more source

Tumor-Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion. [PDF]

Adv Sci (Weinh)
Cheng JY, Tsai HH, Hung JT, Hung TH, Lin CC, Lee CW, Lo ZC, Huang JR, Chiou SP, Huang Y, Chen SH, Yeh CN, Yu J, Yu AL.   +13 more
europepmc   +1 more source

A_2A adenosine receptor agonists, antagonists, inverse agonists and partial agonists. [PDF]

Int Rev Neurobiol, 2023
Jacobson KA, Suresh RR, Oliva P.
europepmc   +1 more source

Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia [PDF]

, 2017
Paulo Alexandre de Oliveira, James A. R. Dalton, Marc López‐Cano, Adrián Ricarte, Xavier Morató, Filipe C. Matheus, Andréia S. Cunha, Christa E. Müller, Reinaldo Ν. Takahashi, Víctor Fernández‐Dueñas, Jesús Giraldo, Rui Daniel Prediger, Francisco Ciruela   +12 more
openalex   +1 more source

Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.

Journal of Clinical Investigation, 2014
Y. Sassi, A. Ahles, Dong-Jiunn Jeffery Truong, Younis Baqi, Sang-Yong Lee, B. Husse, J. Hulot, A. Foinquinos, T. Thum, C. Müller, A. Dendorfer, B. Laggerbauer, S. Engelhardt   +12 more
semanticscholar   +1 more source

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

Arginine Metabolism and Adenosine Receptor Signals in the Cerebellum Contribute to Nicotine Withdrawal-Induced Anxiety/Depression-Like Behaviours. [PDF]

Addict Biol
Zhang W, Tian Y, Yang X, He B, Zhang H, Zhang Q, Mei Y.   +6 more
europepmc   +1 more source

Caffeine for Prevention of Alzheimer's Disease: Is the A_2A Adenosine Receptor Its Target? [PDF]

Biomolecules, 2023
Merighi S, Travagli A, Nigro M, Pasquini S, Cappello M, Contri C, Varani K, Vincenzi F, Borea PA, Gessi S.   +9 more
europepmc   +1 more source

Temperoammonic Stimulation Depotentiates Schaffer Collateral LTP via p38 MAPK Downstream of Adenosine A1 Receptors [PDF]

, 2019
Yukitoshi Izumi, Charles F. Zorumski
openalex   +1 more source