Results 171 to 180 of about 2,712,589 (407)

Novel Adenosine Receptor Antagonists for Treating Cancer and Immune-Related Disorders. [PDF]

ACS Med Chem Lett, 2023
Sabnis RW.
europepmc   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source

The belated US FDA approval of the adenosine A2A receptor antagonist istradefylline for treatment of Parkinson’s disease

Purinergic Signalling Purinergic Signalling, 2020
Jiang-fan Chen, R. Cunha
semanticscholar   +1 more source

Adenosine A\u3csub\u3e1\u3c/sub\u3e receptor-mediated protection of mouse hippocampal synaptic transmission against oxygen and/or glucose deprivation: A comparative study [PDF]

, 2019
© 2019 the American Physiological Society. Adenosine receptors are widely ex-pressed in the brain, and adenosine is a key bioactive substance for neuroprotection.
Kawamura, Masahito, Masino, Susan A., Ruskin, David N.   +2 more
core   +1 more source

Manipulation of Oxygen Tension in Damaged Regions via Hypoxia‐Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration

Advanced Science, EarlyView.
A novel interpenetrating network hydrogel microsphere (NSC‐Exos@HIMS) is developed to manipulate oxygen tension in damaged regions and recruit endogenous stem cells. In vitro and in vivo results show that NSC‐Exos@HIMS maintains the hypoxia microenvironment for up to 5 days, which triggers nucleus pulposus cell‐like differentiation and enhanced ECM ...
Xingdie Zhou, Zhendong Lv, Zehao Chen, Yiming Xu, Chao Lin, Li Liu, Hao Chen, Bing Niu, Wenguo Cui, Yuhui Zhang   +9 more
wiley   +1 more source

A_2A adenosine receptor agonists, antagonists, inverse agonists and partial agonists. [PDF]

Int Rev Neurobiol, 2023
Jacobson KA, Suresh RR, Oliva P.
europepmc   +1 more source

Characterization and localization of adenosine receptors in rat spinal cord [PDF]

, 1984
JD Geiger, FS LaBella, J.I. Nagy
openalex   +1 more source

Adenosine Receptors as Mediators of Both Cell Proliferation and Cell Death of Cultured Human Melanoma Cells [PDF]

Adenosine displays contradictory effects on cell growth: it improves cell proliferation, but it may also induce apoptosis and impair cell survival. Following the pharmacologic characterization of adenosine receptor expression on the human melanoma cell ...
Baraldi, Pier Giovanni, Borea, Pier Andrea, Gessi, Stefania, Klotz, Karl-Norbert, Leung, Edward, Merighi, Stefania, Milani, Daniela, Mirandola, Prisco, Varani, Katia   +8 more
core   +1 more source

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

Peripheral Antinociception by Carbamazepine in an Inflammatory Mechanical Hyperalgesia Model in the Rat: a New Target for Carbamazepine?

Journal of Pharmacological Sciences, 2006
.: This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100 – 1000 nmol/paw) coadministrated with
Sonja Vučković, Maja Tomić, Radica Stepanović-Petrović, Nenad Ugrešić, Milica Prostran, Bogdan Bošković   +5 more
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