Results 161 to 170 of about 1,615,435 (305)

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Adenosine Receptor Functionality and Desensitization Machinery in a Neuronal Cell Model of Angelman Syndrome. [PDF]

J Dev Biol
Contestabile M, Martins de Almeida JF, De Cesari C, Tonazzini I, Artini PG, Daniele S.   +5 more
europepmc   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Pulsed Electromagnetic Field Exposure Attenuates Ultraviolet B-Induced Dermal Collagen Loss in Association with A2A Adenosine Receptor Signaling. [PDF]

Int J Mol Sci
Byun KA, Lee JI, Oh S, Kim SE, Seo SB, Son KH, Byun K.   +6 more
europepmc   +1 more source

FLUORESCENT ANTAGONISTS OF THE A3 ADENOSINE RECEPTOR

, 2013
Disclosed are compounds which are fluorescently labeled antagonists of the A3 adenosine receptor. Also disclosed are diagnostic of a patient for a possible treatment by an antagonist if the A3 adenosine receptor, involving the use of one or more of these
Santosh Kumar Thatikonda, Eszter Erika Kozma, Kenneth A. Jacobson, Stefano Moro, SPALLUTO, GIAMPIERO, FEDERICO, STEPHANIE   +5 more
core  

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

The anti-obesity effect of namodenoson, an A3 adenosine receptor agonist. [PDF]

Int J Obes (Lond)
Fishman P, Itzhak I, Safadi R, Amer J, Salhab A, Bareket-Samish A.   +5 more
europepmc   +1 more source

Allosteric Modulators of the A1 Adenosine receptor

, 2011
The present invention provides compounds active as allosteric modulators of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor, such as treatment of pain, in particular chronic pain
ROMAGNOLI, Romeo, BARALDI, Pier Giovanni, A. R. Moorman   +2 more
core  

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Correction: Unlocking the adenosine receptor mechanism of the tumour immune microenvironment. [PDF]

Front Immunol
Han Y, Dong C, Hu M, Wang X, Wang G.
europepmc   +1 more source