Results 171 to 180 of about 1,615,435 (305)

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

A₃ adenosine receptor regulates depression-like behaviors through astrocyte-nourished excitatory synapse formation. [PDF]

iScience
Li B, Zeng M, Liu J, Huang W, Pan D, Xiao C, Du J.   +6 more
europepmc   +1 more source

Adenosine; adenosine A2b receptor [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Piclidenoson, an A3 adenosine receptor agonist, demonstrates clinical benefit in canine osteoarthritis: a pilot study. [PDF]

Front Vet Sci
Hanf R, Bareket-Samish A, Moulin P, Manias F, Seguela J, Baulez B, Sutre V, Koch JB, Salindre J, Dubruque M, Tierny D, Fishman S, Fishman P.   +12 more
europepmc   +1 more source

Allosteric modulators of the A1 adenosine receptor

, 2008
Title compd. I [R1 = H, (un)substituted alkyl, aryl or cycloalkyl; R2, R3 and R4 independently = H, halo, OH, NO2, CN, (un)substituted alkyl, aryl, cycloalkyl or alkoxy; Q = (un)substituted piperidinyl, azepinyl, 5-membered spirocyclic ring, etc.], and ...
ROMAGNOLI, Romeo, Moorman A. R., BARALDI, Pier Giovanni   +2 more
core  

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Atomistic insights into the magnetic-field modulation of the [Formula: see text] adenosine receptor. [PDF]

Sci Rep
Pisano C, Signore FD, Marracino P, Pappa I, Cocco D, Valle ED, Salati S, Cadossi R, Liberti M, Apollonio F.   +9 more
europepmc   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Bezafibrate prolongs hypothermia induced by an A₁ adenosine receptor agonist in CBA/N mice. [PDF]

J Vet Med Sci
Sato-Hashimoto M, Ohnishi H.
europepmc   +1 more source