Results 221 to 230 of about 2,608,509 (268)

Upconversion Nanoparticles‐Based Multimodal Tumor Therapy Integrating Photoclick‐Induced Aggregation of Gold Nanoparticles and Ceria‐Curcumin Redox Modulation With Inflammation Attenuation Post‐Treatment

Aggregate, EarlyView.
A multifunctional nanoplatform (USiCeCurAu) integrating UCNPs, AuNPs, CeO2, and TK‐CUR‐TPP enables synergistic PDT, CDT, and mPTT. The AuNPs act as pore lockers, UCNPs convert NIR into UV/Vis emission, which triggers AuNPs aggregation, TPP‐CUR‐mediated mitochondria damage for HSP70 suppression, and CeO2‐enabled dual role in ROS generation and ...
Junyou Li, Man Lung Lee, Pinyou Chen, Kaiqi Hu, Ting Li, Zheng Zou, Qingting Song, Chengke Wang, Hung‐Wing Li   +8 more
wiley   +1 more source

Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A₃ adenosine receptor in HL-60 cells. [PDF]

Purinergic Signal
Gao ZG, Chen W, Gao RR, Li J, Tosh DK, Hanover JA, Jacobson KA.   +6 more
europepmc   +1 more source

The Fast‐Growing Field of Cancer Immunotherapy Based on Aggregation‐Induced Emission

Aggregate, EarlyView.
Photoimmunotherapy facilitated by AIEgens represents an emerging cancer treatment that combines high‐performance phototheranostics with immunotherapy to achieve satisfactory antitumor effectiveness, and has recently been developed at a tremendous pace and attracted global interests in the past few years.
Zhijie Lin, Tingting He, Miaomiao Kang, Wei Xie, Dong Wang, Ben Zhong Tang   +5 more
wiley   +1 more source

Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems

Aggregate, EarlyView.
Schematic illustration of engineered RNA devices for in vivo targeted therapeutics via advanced delivery systems. ABSTRACT Engineered RNA devices can identify disease‐specific markers and precisely regulate gene expression, which is of great significance to the development of precision medicine.
Wei Luo, Xia Liu, Ying Han, Yijing Duan, Chuao Yu, Na Kong, Tian Xie   +6 more
wiley   +1 more source

Overcoming Clinical Barriers: Utilizing Self‐Assembly Systems to Break the Protease Limitations of Antimicrobial Peptides

Aggregate, EarlyView.
This study addresses AMPs' clinical application challenges by enhancing stability via molecular assembly. Pba* shows high antibacterial activity, biocompatibility, and low toxicity, paving the way for antimicrobial materials. ABSTRACT Natural antimicrobial peptides (AMPs) encounter significant challenges in transitioning to clinical application ...
Xu Guo, Weikang Yu, Qingrui Li, Xuefeng Li, Yingxin Wei, Jiajun Wang, Yinfeng Lyu, Anshan Shan   +7 more
wiley   +1 more source

Antidepressant effects of selective adenosine receptor antagonists targeting the A1 and A2A receptors administered jointly with NMDA receptor ligands: behavioral, biochemical and molecular investigations in mice. [PDF]

Pharmacol Rep
Szopa A, Bogatko K, Serefko A, Herbet M, Ostrowska-Leśko M, Wróbel A, Radziwoń-Zaleska M, Dudka J, Wlaź P, Poleszak E.   +9 more
europepmc   +1 more source

Macrophage Phenotype Detection Methodology on Textured Surfaces via Nuclear Morphology Using Machine Learning

Advanced Intelligent Discovery, EarlyView.
A novel machine learning approach classifies macrophage phenotypes with up to 98% accuracy using only nuclear morphology from DAPI‐stained images. Bypassing traditional surface markers, the method proves robust even on complex textured biomaterial surfaces. It offers a simpler, faster alternative for studying macrophage behavior in various experimental
Oleh Mezhenskyi, Kateryna Andriienkova, Tetyana Goldanova, Ezgi Antmen, Thibaut Soubrie, Nihal Engin Vrana   +5 more
wiley   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Low‐Dose X‐Ray Radiation Enhances Intratumoral Accumulation and Antitumor Effects of Nanoscale Coordination Polymers via Neutrophil‐Mediated Trafficking

Advanced NanoBiomed Research, EarlyView.
Low‐dose radiotherapy has been shown to direct nanoscale coordination polymers (NCPs) to tumors by promoting neutrophil recruitment. This immune‐mediated delivery strategy markedly enhances tumor targeting and the therapeutic efficacy of NCPs carrying combination chemotherapies or innate immune modulators, even under clinically relevant radiation ...
Langston Tillman, Xiaomin Jiang, Chaoyu Wang, Yuxuan Xiong, Wenbin Lin   +4 more
wiley   +1 more source