Results 211 to 220 of about 1,615,435 (305)

Adenosine receptor subtype modulators: Insight into molecular mechanisms and their therapeutic application. [PDF]

Am J Transl Res
Solanki N, Dodiya R, Vejpara D, Azad S, Patel M, Patel S, Shah U, Soni A, Maheshwari R, Navale A, Patel A, Patel S, Sheth D, Tirgar P, R R.   +14 more
europepmc   +1 more source

Astrocyte SMN Restoration and Forskolin Treatment Improve SMA Synaptic Pathology

Annals of Neurology, EarlyView.
Objective Early phenotypic presentation of central afferent synapse dysfunction within patients with spinal muscular atrophy (SMA) represents a key target for therapeutic development; however, the underlying disease mechanisms remain unresolved. By further investigating motor neuron synapse and peri‐synaptic astrocyte process (PAP) defects in human SMA
Emily Welby, Xiaojie Liu, Melinda Wojtkiewicz, Linda Berg Luecke, Rebekah L. Gundry, Qing‐Song Liu, Allison D. Ebert   +6 more
wiley   +1 more source

dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

Angewandte Chemie, EarlyView.
Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng, Tyson D. Todd, Alexandria L. Quillin, Harshad Ingle, Angela M. Halstead, Megan T. Baldridge, José B. Sáenz, Jennifer M. Heemstra   +7 more
wiley   +2 more sources

Structural Simplification from Tricyclic to Bicyclic Scaffolds: A Long-Term Investigation in the Field of Adenosine Receptor Antagonists. [PDF]

Cells
Ceni C, Calenda S, Vagnoni G, Catarzi D, Varano F, Colotta V.   +5 more
europepmc   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Arginine Metabolism and Adenosine Receptor Signals in the Cerebellum Contribute to Nicotine Withdrawal-Induced Anxiety/Depression-Like Behaviours. [PDF]

Addict Biol
Zhang W, Tian Y, Yang X, He B, Zhang H, Zhang Q, Mei Y.   +6 more
europepmc   +1 more source

Caffeine Mitigates Adenosine-Mediated Angiogenic Properties of Choroidal Endothelial Cells Through Antagonism of A₁ Adenosine Receptor and PI3K-AKT Axis. [PDF]

Cells
Park S, Song YS, Feng X, Sorenson CM, Sheibani N.   +4 more
europepmc   +1 more source

A_2A Adenosine Receptor Antagonists and Their Efficacy in Rat Models of Parkinson's Disease. [PDF]

Cells
Spinaci A, Buccioni M, Dal Ben D, Francucci B, Klotz KN, Marucci G, Simola N, Morelli M, Pinna A, Volpini R, Lambertucci C.   +10 more
europepmc   +1 more source

A new approach to psoriasis therapy: photoswitchable A₃ adenosine receptor activation. [PDF]

Purinergic Signal
Cherchi F, Coppi E.
europepmc   +1 more source

First-in-human study of the dual A₂_A/A₂_B adenosine receptor antagonist muvadenant (M1069) in patients with advanced solid tumors. [PDF]

ESMO Open
Siu LL, Gutierrez ME, Pudelko L, Ruth K, Filho MAFN, Zaynagetdinov R, Hu P, Kitzing T, Guenhan BK, Durutovic I, McKean M.   +10 more
europepmc   +1 more source