Results 221 to 230 of about 1,615,435 (305)

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Insights from Clinical Trials on A_2A Adenosine Receptor Antagonists for Cancer Treatment. [PDF]

ACS Pharmacol Transl Sci
Deb PK, Maity P, Sarkar B, Venugopala KN, Tekade RK, Batra S.   +5 more
europepmc   +1 more source

Bile acids inhibit equilibrative adenosine transport to alter adenosine receptor signaling in cholestasis. [PDF]

J Biol Chem
Joshi A, Chen S, Rahman FM, Nair S, Cheng X, Govindarajan R.   +5 more
europepmc   +1 more source

Potential Application of Cocoa Extract in Preventing Skin Cancer Through Inhibition of Adenosine Receptor A2, VEGFR-2, and BCL-2: <i>in vivo</i> and Docking Molecular Studies. [PDF]

Medeni Med J
Wahab S, Djawad K.
europepmc   +1 more source

Dietary Glutamine Supplementation Alleviated Rumen Epithelium Oxidative Damage and Apoptosis Induced by Feed Restriction via Maintaining Mitochondrial Homeostasis in Female Yaks

Animal Research and One Health, EarlyView.
Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue, Shanpeng Ke, Liyuan Shi, Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, Jianxin Xiao, Yahui Jiang, Fali Wu, Yiping Tang   +10 more
wiley   +1 more source

A_2B adenosine receptor signaling and regulation. [PDF]

Purinergic Signal
Gao ZG, Haddad M, Jacobson KA.
europepmc   +1 more source

Cross‐Species Single‐Cell Comparative Analysis Reveals Gluconeogenic Features of Hepatocytes in Ruminants

Animal Research and One Health, EarlyView.
In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou, Wuqiang Huo, Yingran Liu, Yihang Liu, Fei Wang, Tao Shi, Yu Jiang   +6 more
wiley   +1 more source

Anticancer Activity of Triterpene Glycosides Cucumarioside A₀-1 and Djakonovioside A Against MDA-MB-231 as A_2B Adenosine Receptor Antagonists. [PDF]

Int J Mol Sci
Zelepuga EA, Chingizova EA, Menchinskaya ES, Pislyagin EA, Avilov SA, Kalinin VI, Aminin DL, Silchenko AS.   +7 more
europepmc   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Unlocking the adenosine receptor mechanism of the tumour immune microenvironment. [PDF]

Front Immunol
Han Y, Dong C, Hu M, Wang X, Wang G.
europepmc   +1 more source