Results 241 to 250 of about 2,801,899 (401)

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, EarlyView.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

Adenosine receptor subtype modulators: Insight into molecular mechanisms and their therapeutic application. [PDF]

Am J Transl Res
Solanki N, Dodiya R, Vejpara D, Azad S, Patel M, Patel S, Shah U, Soni A, Maheshwari R, Navale A, Patel A, Patel S, Sheth D, Tirgar P, R R.   +14 more
europepmc   +1 more source

Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor

Molecular Pharmacology, 2015
G. Lebon, P. Edwards, A. Leslie, C. Tate
semanticscholar   +1 more source

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

Adenosine Receptor Mechanisms Underlying Bladder Dysfunction in Male Rats With Bladder Outlet Obstruction. [PDF]

Neurourol Urodyn
Takaoka EI, Kurobe M, Matsuoka K, Kamijo T, Kimura S, Watton PN, Robertson AM, Yoshimura N.   +7 more
europepmc   +1 more source

A_2A adenosine receptor agonists, antagonists, inverse agonists and partial agonists. [PDF]

Int Rev Neurobiol, 2023
Jacobson KA, Suresh RR, Oliva P.
europepmc   +1 more source

Unraveling the role adenosine A2A receptors on alpha-synuclein-mediated neurotoxicity

, 2018
Diana G. Ferreira
openalex   +2 more sources

Real‐Time In Vivo Monitoring of Anastomotic Intestinal Ischemia Using Implantable Resorbable Organic Sensors

Advanced Science, EarlyView.
Resorbable impedance sensors are successfully implanted into porcine small intestinal anastomoses. Impedance was recorded for 2 hours prior, and 2 hours following ischemia induction, and a significant drop in tissue impedance was observed. Abstract Anastomotic failure remains one of the most severe complications in gastrointestinal surgery.
Dennis Wahl, Finn Jaekel, Julia Henne, Richard Kantelberg, Daniel C. Freund, Eberhard Grambow, Brigitte Vollmar, Amelie R. Zitzmann, Hans Kleemann, Jochen Hampe, Sebastian Hinz, Clemens Schafmayer, Karl Leo   +12 more
wiley   +1 more source

A new approach to psoriasis therapy: photoswitchable A₃ adenosine receptor activation. [PDF]

Purinergic Signal
Cherchi F, Coppi E.
europepmc   +1 more source

Improving combination therapies: targeting A2B-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression. [PDF]

J Natl Cancer Inst, 2023
Evans JV, Suman S, Goruganthu MUL, Tchekneva EE, Guan S, Arasada RR, Antonucci A, Piao L, Ilgisonis I, Bobko AA, Driesschaert B, Uzhachenko RV, Hoyd R, Samouilov A, Amann J, Wu R, Wei L, Pallerla A, Ryzhov SV, Feoktistov I, Park KP, Kikuchi T, Castro J, Ivanova AV, Kanagasabai T, Owen DH, Spakowicz DJ, Zweier JL, Carbone DP, Novitskiy SV, Khramtsov VV, Shanker A, Dikov MM.   +32 more
europepmc   +1 more source