Results 71 to 80 of about 187,970 (266)

Clinicopathological characterization of vacuolar tauopathy associated with VCP D395G

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION The clinical, radiological, and pathological features have not been well documented for the recently discovered autosomal‐dominant vacuolar tauopathy (VT) harboring the Valosin‐containing protein (VCP) p.Asp395Gly variant. METHODS We investigated the clinical, neuropsychological, physiological, laboratory, and radiological data ...
Ryohei Watanabe, John D. Papatriantafyllou, Kengo Maeda, Geoffrey K. Aguirre, Masahiro Ando, Bernice Benoit, Murray Grossman, David J. Irwin, Boram Kim, Lauren Massimo, Corey T. McMillan, Sokratis G. Papageorgiou, Jeffrey S. Phillips, Tomoyuki Shiraishi, Yoshiko Sugihara, EunRan Suh, Hiroshi Takashima, Camilo Toro, Vivianna M. Van Deerlin, Ilya M. Nasrallah, Edward B. Lee   +20 more
wiley   +1 more source

ATP11C mutation is responsible for the defect in phosphatidylserine uptake in UPS-1 cells

Journal of Lipid Research, 2015
Type IV P-type ATPases (P4-ATPases) translocate phospholipids from the exoplasmic to the cytoplasmic leaflets of cellular membranes. We and others previously showed that ATP11C, a member of the P4-ATPases, translocates phosphatidylserine (PS) at the ...
Naoto Takada, Hiroyuki Takatsu, Rie Miyano, Kazuhisa Nakayama, Hye-Won Shin   +4 more
doaj  

Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease [PDF]

, 2017
Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system.
Matsakas, Antonios, Sfyri, Peggy
core   +1 more source

Shedding Light on the Phytochemical and Biological Fingerprints of Fibigia clypeata (L.) Medik Essential Oil as a Pharmacotherapeutic Agent

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This study aims to analyze the phytochemical composition and in silico and in vitro biological activity of Fibigia clypeata (L.) Medik essential oil is a natural pharmaceutical source for the first time in the literature. GC–MS Analysis showed that dimethyl disulfide and dimethyl trisulfide were the main compounds of the plant essential oil.
Tuba Unver, Murat Bingul, Harun Uslu, Ismet Gurhan, Bunyamin Goktas, Hasan Sahin, Mehmet Boga   +6 more
wiley   +1 more source

Adenosine Triphosphatase Activities of Muscle Sarcolemma

Journal of Biological Chemistry, 1973
Abstract Isolated sarcolemma hydrolyzed ATP in the presence of Mg2+ and Ca2+. MgATPase was stimulated by low concentrations of Ca2+ and inhibited by high concentrations of this cation. Membranes hydrolyzed p-nitrophenylphosphate in the presence of Mg2+; this activity was stimulated by Ca2+ and K+.
George I. Drummond, David C. Ng, Prakash V. Sulakhe   +2 more
openaire   +3 more sources

Toward molecular phenotyping of temporal lobe epilepsy by spatial omics

Epilepsia, Volume 66, Issue 7, Page 2538-2553, July 2025.
Abstract Objective In temporal lobe epilepsy (TLE), detection of the epileptogenic zone predicts a good surgical outcome. When submitted to 18F‐fluorodeoxyglucose positron emission tomography (PET), some patients display lateralized, focal hypometabolism in the temporal lobe (PET+), whereas others appear normometabolic (PET−).
Isabeau Vermeulen, Ronny Mohren, Micca Neusinger, Tobias A. Dancker, Michiel Vandenbosch, Jan Beckervordersandforth, Benjamin Balluff, Rianna P. Van der Hel, Olaf E. M. G. Schijns, Govert Hoogland, Kim Rijkers, Berta Cillero‐Pastor, ACE epilepsy surgery group, Gwendolyn de Bruyn, Albert Colon, Jim Dings, Marc Hendriks, Danny Hilkman, Christianne Hoeberigs, Jochem van der Pol, Lotte de Jong, Kim Rijkers, Sylvia Klinkenberg, Vivianne van Kranen–Mastenbroek, Jeske Nelissen, Pieter Kubben, Walter M. Palm, Rob P. W. Rouhl, Olaf Schijns, Ilse van Straaten, Simon Tousseyn, Marielle Vlooswijk, Louis Wagner, Dorien Weckhuysen   +33 more
wiley   +1 more source

A CNTNAP1 Missense Variant Associated With Laryngeal Paralysis and Polyneuropathy in Young Great Dane Dogs

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT Background Major genetic risk loci and causative mutations classified as LPN1 (Leonberger polyneuropathy type 1), LPN2 (Leonberger polyneuropathy type 2), and LPPN3 (Laryngeal paralysis polyneuropathy type 3) have been identified in Leonberger and Saint Bernard dogs with laryngeal paralysis and polyneuropathy (LPPN).
G. Diane Shelton, Missy C. Carpentier, Y. Michael Kimura, Ling T. Guo, Katie M. Minor   +4 more
wiley   +1 more source

Exercise duration and detraining influence not only body weight but also histopathological changes in the white adipose tissue of young male OLETF rats as an obesity model

Physiological Reports, Volume 13, Issue 14, July 2025.
Abstract Environmental exposures during early life impact health and disease in later life. Therefore, understanding the effects of exercise during early life and detraining on obesity in adulthood may be valuable for preventing and treating obesity. This study aimed to examine the effects of short‐ and long‐term exercise and detraining during early ...
Kanta Sakakura, Susumu Urakawa, Naoto Fujita   +2 more
wiley   +1 more source

Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3 [PDF]

, 2011
The mitogen-activated protein kinase (MAPK) extracellular signal–regulated kinase 2 (ERK2) is ubiquitously expressed in mammalian tissues and is involved in a wide range of biological processes.
Carlson, Scott M., Chouinard, Candace R., Fraenkel, Ernest, Labadorf, Adam, Lam, Carol J., Schmelzle, Katrin, White, Forest M.   +6 more
core   +1 more source

Treatment patterns, outcomes and healthcare resource utilization of obstructive hypertrophic cardiomyopathy in England

ESC Heart Failure, Volume 12, Issue 3, Page 2034-2046, June 2025.
Abstract Aims Describe patient characteristics, treatment patterns, clinical outcomes, healthcare resource utilization (HCRU) and medical costs associated with patients who were diagnosed with obstructive hypertrophic cardiomyopathy (HCM) in clinical practice in England.
Faizel Osman, Carla L. Zema, Michael Hurst, Belinda Sandler, Florence Brellier, Ovie Utuama, Oksana Kirichek, John Houghton, Teresa Lemmer, Maite Tome Esteban   +9 more
wiley   +1 more source