Results 81 to 90 of about 17,597 (256)

Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins [PDF]

open access: yes, 2017
Sirt1 is an NAD(+)-dependent protein deacetylase that regulates many physiological functions, including stress resistance, adipogenesis, cell senescence and energy production.
A Brunet   +64 more
core   +1 more source

The N-terminal domains of Bacillus subtilis CopA do not form a stable complex in the absence of their inter-domain linker [PDF]

open access: yes, 2018
Copper-transporting P-type ATPases, which play important roles in trafficking Cu(I) across membranes for the biogenesis of copper proteins or for copper detoxification, contain a variable number of soluble metal-binding domains at their N-termini.
Achila   +44 more
core   +1 more source

Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle [PDF]

open access: yes, 2017
Insulin resistance is central to the development of type 2 diabetes and related metabolic disorders. Because skeletal muscle is responsible for the majority of whole body insulin-stimulated glucose uptake, regulation of glucose metabolism in this tissue ...
Massart, Julie   +4 more
core   +1 more source

Carcinogenic oestrogens induce respiration deficiency mutation in yeast [PDF]

open access: yes, 1991
In addition to hormonal activity, genetic darnage has been proposed as an important factor in oestrogen-mediated carcinogenesis. However, as short-term tests for oestrogens usually fail to show DNA mutations, lesions other than dassie nuclear DNA ...
Metzler, M., Stopper, Helga
core  

Assessment of the level of muscular strength and volume in physically active English adults [PDF]

open access: yes, 2012
The aim of this study is to describe the muscular volume and strength of different body segments from a sample of 19 English male participants, with a mean age of 43.84 (±11.62).
Leyton Román, Marta   +3 more
core   +3 more sources

The alternate GNB3 splice variant, Gβ3s, exhibits an altered signalling response to EGF stimulation, which leads to enhanced cell migration [PDF]

open access: yes, 2013
It has recently been reported that the duplication of the GNB3 gene has been shown to be directly linked to an obesity phenotype, both in humans and also in a humanised mouse model. Moreover, the common human GNB3 c.825C>T polymorphism (rs5443) causes
D’Ascanio, Isabella   +7 more
core   +5 more sources

Proteomics and bioinformatics analyses identify novel cellular roles outside mitochondrial function for human miro GTPases [PDF]

open access: yes, 2019
The human Miro GTPases (hMiros) have recently emerged as important mediators of mitochondrial transport and may significantly contribute to the development of disorders such as Alzheimer’s and schizophrenia.
Black, Gary   +3 more
core   +1 more source

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