Results 111 to 120 of about 250,818 (300)

Optical Aptasensors for Adenosine Triphosphate

Theranostics, 2016
Nucleic acids are among the most researched and applied biomolecules. Their diverse two- and three-dimensional structures in conjunction with their robust chemistry and ease of manipulation provide a rare opportunity for sensor applications. Moreover, their high biocompatibility has seen them being used in the construction of in vivo assays.
Ng, Stella, Lim, Hui Si, Ma, Qian, Gao, Zhiqiang   +3 more
openaire   +2 more sources

Luminescence fold change of the system for 1′-triphosphate (UTP), guanosine 5′-triphosphate (GTP), cytidine 5′-triphosphate (CTP), adenosine 5′-diphosphate (ADP), adenosine 5′-monophosphate (AMP), 300 mM NaCl, 2% glucose and 0.05% serum albumin (SA).

, 2013
Luminescence fold change of the system for 1′-triphosphate (UTP), guanosine 5′-triphosphate (GTP), cytidine 5′-triphosphate (CTP), adenosine 5′-diphosphate (ADP), adenosine 5′-monophosphate (AMP), 300 mM NaCl, 2% glucose and 0.05% serum albumin (SA).
Dik-Lung Ma (103041), Lihua Lu (476939), Chung-Hang Leung (118097), Tsun-Yin Mak (476940), Fung-Kit Tang (476941), Ka-Ho Leung (476938), Modi Wang (393693), Zhiling Yu (476942), Daniel Shiu-Hin Chan (118095), Hiu-Yee Kwan (283308)   +9 more
core   +1 more source

Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice [PDF]

, 2015
The authors are grateful for support from the Wellcome Trust.Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS,
Witts, Emily Charlotte, Miles, Gareth Brian, Nascimento, Filipe   +2 more
core   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

PHOSPHONIC ACID ANALOGS OF ADENOSINE-DIPHOSPHATE AND ADENOSINE-TRIPHOSPHATE.

, 1963
PHOSPHONIC ACID ANALOGS OF ADENOSINE-DIPHOSPHATE AND ADENOSINE ...
ALBERT BABA. DANIELZADEH (7953785)
core  

Activity-dependent adenosine release may be linked to activation of Na+-K+ ATPase : an in vitro rat study [PDF]

, 2014
In the brain, extracellular adenosine increases as a result of neuronal activity. The mechanisms by which this occurs are only incompletely understood. Here we investigate the hypothesis that the Na+ influxes associated with neuronal signalling activate ...
Sims, Robert E., Sims Robert Edward, Dale, Nicholas, Sims, Robert, Dale Nicholas, Robert Edward Sims, Nicholas Dale   +6 more
core   +2 more sources

Nano‐Confined Radical Anion as An NIR‐II Photothermal Immunogenic Amplifier for In Situ Cancer Vaccination

Advanced Science, EarlyView.
A nano‐confined radical anion acts as a photothermal immunogenic amplifier. Kinetically stabilized nanoparticles couple high near‐infrared‐II (NIR‐II) photothermal efficacy with glutathione (GSH) depletion to boost reactive oxygen species (ROS) and immunogenic cell death (ICD).
Mengxin Mu, Mengyu Guo, Jun Guan, Xiaofeng He, Mingdi Hu, Fene Gao, Klaus Müllen, Chendong Ji, Chunying Chen, Meizhen Yin   +9 more
wiley   +1 more source

Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication

, 2012
Background and purpose: Methamphetamine is a powerful addictive, which has been associated with ischemic stroke and brain hemorrhage in humans. Whether and how methamphetamine influences the expression of tight junctions and adenosine triphosphate ...
ElAli, Ayman, Hernández Jiménez, Macarena, Doeppner, Thorsten R, Hermann, Dirk M, Urrutia, Andrés, Rubio-Araiz, Ana, Colado, Maria I   +6 more
core   +1 more source

NIR‐II Light‐Triggered Electron Flow Initiates Cuproptosis‐Centered Thermoelectric‐Immunotherapy for Breast Cancer

Advanced Science, EarlyView.
A NIR‐II light‐activatable thermoelectric nanoreactor converts surface‐bound Cu2+ into bioactive Cu+ via directed electron flow. This spatiotemporally controlled reduction triggers potent cuproptosis and immunogenic cell death, eradicating primary tumors and, together with aPD‐1 therapy, suppressing metastases while establishing durable immune memory ...
Boyu Yuan, Qin Fan, Shushu Chu, Shining Yang, Yuechao Yang, Chenxi Zhang, Jinqiao Zhang, Xinran Qu, Yiju Wei, Xin Wang, Ziliang Dong   +10 more
wiley   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source